EPM2A and PPP1R3D

Number of citations of the paper that reports this interaction (PubMedID 30041081)
63

Data Source:
BioGRID (two hybrid)

		EPM2A	PPP1R3D
Description		EPM2A glucan phosphatase, laforin	protein phosphatase 1 regulatory subunit 3D
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Dendrite Perikaryon Cytoplasmic Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane	Protein Phosphatase Type 1 Complex Glycogen Granule
	Molecular Function	Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Carbohydrate Phosphatase Activity Carbohydrate Binding Polysaccharide Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Glycogen Binding Starch Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase 1 Binding Enzyme Binding Glycogen Binding
	Biological Process	Autophagosome Assembly Regulation Of Cell Growth Glycogen Metabolic Process Glycogen Biosynthetic Process Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Calcium Ion Transport Autophagy Mitochondrion Organization Nervous System Development Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Phosphatase Activity Glial Cell Proliferation L-glutamate Transmembrane Transport Wnt Signaling Pathway Positive Regulation Of Macroautophagy Dephosphorylation Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Negative Regulation Of Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Carbohydrate Phosphorylation Habituation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Plasma Membrane	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Loneliness (multivariate analysis) ( 27629369) Mean platelet volume ( 27863252 32888494) Methadone dose in opioid dependence ( 28115739) Response to mepolizumab in severe asthma ( 29229094)	Delirium ( 29631748)
Interacting Genes		15 interacting genes: COX5A EIF2B1 EPM2AIP1 HMGXB4 NFU1 PKM PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB2 PSMC3 SRPK2 TDG TOPORS	4 interacting genes: EPM2A PPP1CA PPP1CC YWHAZ
Entrez ID		7957	5509
HPRD ID		06345	04507
Ensembl ID		ENSG00000112425	ENSG00000132825
Uniprot IDs		O95278	O95685 Q86X09
PDB IDs		4R30 4RKK
Enriched GO Terms of Interacting Partners?		AMP-activated Protein Kinase Activity Regulation Of Generation Of Precursor Metabolites And Energy Nucleotide-activated Protein Kinase Complex Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Glycogen Biosynthetic Process Protein Localization To Lipid Droplet Generation Of Precursor Metabolites And Energy Regulation Of Glycogen Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Carbohydrate Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glycogen Metabolic Process Regulation Of Carbohydrate Catabolic Process Glycogen Binding Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Protein Phosphatase Type 1 Complex Fatty Acid Homeostasis Hepatocyte Apoptotic Process Glycogen Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Response To Hormone Fatty Acid Biosynthetic Process Response To Glucose Chromatin Remodeling Polysaccharide Biosynthetic Process Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Protein Phosphatase 1 Binding Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Prostaglandin Stimulus Response To Monosaccharide Protein K6-linked Ubiquitination Response To Prostaglandin E Negative Regulation Of Epithelial Cell Apoptotic Process Phosphatidylethanolamine Metabolic Process Positive Regulation Of Translation Positive Regulation Of Small Molecule Metabolic Process Response To Carbohydrate Macromolecule Metabolic Process Nuclear Speck Cholesterol Biosynthetic Process Positive Regulation Of ATP Metabolic Process	Glycogen Metabolic Process Energy Reserve Metabolic Process Phosphatase Activity Polysaccharide Metabolic Process Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity PTW/PP1 Phosphatase Complex Dephosphorylation Phosphoprotein Phosphatase Activity Energy Derivation By Oxidation Of Organic Compounds Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock Generation Of Precursor Metabolites And Energy Phosphate-containing Compound Metabolic Process Carbohydrate Metabolic Process Protein Modification Process Circadian Regulation Of Gene Expression Glutamatergic Synapse Negative Regulation Of TOR Signaling Protein Phosphatase Binding Lung Development Carbohydrate Phosphatase Activity Regulation Of Circadian Rhythm Regulation Of Nucleocytoplasmic Transport Circadian Rhythm Organelle Organization Perikaryon Dendritic Spine RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of TOR Signaling Synaptic Target Recognition Regulation Of Protein Localization To Nucleus Chromosome, Telomeric Region Vacuole Organization Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Negative Regulation Of Phosphatase Activity Starch Binding Protein Metabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Habituation Protein Domain Specific Binding Presynapse Postsynapse MAPK Cascade Golgi Reassembly Rhythmic Process
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