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RAB7A and RAB4A
Number of citations of the paper that reports this interaction (PubMedID
40437099
)
172
Data Source:
BioGRID
(two hybrid, proximity labelling technology, proximity labelling technology, cross-linking study)
RAB7A
RAB4A
Description
RAB7A, member RAS oncogene family
RAB4A, member RAS oncogene family
Image
GO Annotations
Cellular Component
Autophagosome Membrane
Cytoplasm
Mitochondrion
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Golgi Apparatus
Lipid Droplet
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Secretory Granule Membrane
Phagocytic Vesicle Membrane
Synaptic Vesicle Membrane
Retromer Complex
Cytoplasmic Vesicle
Late Endosome Membrane
Mitochondrial Membrane
Melanosome Membrane
Phagophore Assembly Site Membrane
Phagocytic Vesicle
Extracellular Exosome
Alveolar Lamellar Body
Bounding Membrane Of Organelle
Presynaptic Endosome
Glutamatergic Synapse
Cytoplasm
Endosome
Membrane
Cytoplasmic Vesicle Membrane
Early Endosome Membrane
Vesicle
Insulin-responsive Compartment
Perinuclear Region Of Cytoplasm
Recycling Endosome
Recycling Endosome Membrane
Extracellular Exosome
Glutamatergic Synapse
Molecular Function
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Small GTPase Binding
Retromer Complex Binding
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Metal Ion Binding
Biological Process
Autophagosome Assembly
Protein Targeting To Lysosome
Lipid Metabolic Process
Endocytosis
Autophagy
Epidermal Growth Factor Catabolic Process
Endosome To Lysosome Transport
Response To Bacterium
Protein Transport
Lipid Catabolic Process
Viral Release From Host Cell
Protein To Membrane Docking
Synaptic Vesicle Recycling Via Endosome
Retrograde Transport, Endosome To Golgi
Early Endosome To Late Endosome Transport
Bone Resorption
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Viral Process
Establishment Of Vesicle Localization
Protein Localization To Lysosome
Lipophagy
Phagosome Maturation
Phagosome Acidification
Phagosome-lysosome Fusion
Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome
Vesicle-mediated Transport In Synapse
Endosome To Plasma Membrane Protein Transport
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Exosomal Secretion
Negative Regulation Of Intralumenal Vesicle Formation
Small GTPase-mediated Signal Transduction
Protein Transport
Vesicle-mediated Transport
Antigen Processing And Presentation
Regulation Of Endocytosis
Rab Protein Signal Transduction
Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome
Vesicle-mediated Transport In Synapse
Pathways
MHC class II antigen presentation
Neutrophil degranulation
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RAC3 GTPase cycle
RHOF GTPase cycle
Prevention of phagosomal-lysosomal fusion
Suppression of autophagy
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Synthesis of PIPs at the plasma membrane
TBC/RABGAPs
RAB geranylgeranylation
MET receptor recycling
Drugs
Guanosine-5'-Diphosphate
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Body fat mass (
28552196
)
Facial morphology traits (63 three-dimensional facial segments) (
29459680
)
Aging (
22773346
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Leukoderma in response to rhododendrol (
32558222
)
Mean arterial pressure (alcohol consumption interaction) (
24376456
)
Mercury levels (
26025379
)
Response to antidepressants in depression (
27622933
)
Interacting Genes
24 interacting genes:
CHM
KRTAP10-3
KRTAP10-9
PPP2R1A
PPP2R1B
PRKN
RAB13
RAB17
RAB22A
RAB4A
RAB4B
RAB6A
RABAC1
RABGGTB
RILP
RNF115
RNF167
SLC2A4
TP53
UCHL5
VPS11
VPS16
VPS18
VPS41
33 interacting genes:
ACTB
APBB3
CD2AP
CDK1
CHM
DYNC1LI1
DYNLL1
EXOC5
GARIN6
GDI2
GRIPAP1
HACE1
IDH3A
KCTD7
KIF3B
MAPK3
PIN1
PRKCI
PTTG1IP
RAB11FIP1
RAB7A
RABAC1
RABEP1
RABGAP1
RABGEF1
RBSN
RUFY1
SNCA
SOD2
STX4
TP53
VPS52
ZNF830
Entrez ID
7879
5867
HPRD ID
03805
01541
Ensembl ID
ENSG00000075785
ENSG00000168118
Uniprot IDs
A0A158RFU6
P51149
A0A087WYT5
P20338
PDB IDs
1T91
1YHN
3LAW
6IYB
6WCW
7F6J
8KB8
8ZQ3
1YU9
1Z0K
2BMD
2BME
Enriched GO Terms of Interacting Partners
?
Vesicle-mediated Transport
Intracellular Transport
Endosomal Vesicle Fusion
Cellular Localization
Establishment Of Localization In Cell
Insulin-responsive Compartment
Protein Transport
Endosome
HOPS Complex
Regulation Of SNARE Complex Assembly
Establishment Of Protein Localization
Intracellular Protein Transport
Endosome To Lysosome Transport
Vesicle Organization
Lysosomal Transport
Intracellular Protein Localization
Cytoplasmic Vesicle
CORVET Complex
Clathrin-coated Vesicle
Endosomal Transport
Endosome Organization
Late Endosome
Endomembrane System
Vacuolar Transport
Golgi Vesicle Transport
Vesicle Fusion
Organelle Membrane Fusion
Organelle Organization
Organelle Fusion
Recycling Endosome
Membrane Fusion
Late Endosome Membrane
Endosome Membrane
Cytosol
Autophagy
Rab-protein Geranylgeranyltransferase Complex
Rab Geranylgeranyltransferase Activity
Organelle Localization
Meiotic Sister Chromatid Cohesion, Centromeric
Membrane Organization
Vesicle Tethering Complex
GTPase Activity
Early Endosome
GTP Binding
Protein Geranylgeranylation
Lysosomal Membrane
Presynapse
Protein Prenylation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Meiotic Sister Chromatid Cohesion
Establishment Of Protein Localization
Intracellular Protein Localization
Protein Transport
Vesicle-mediated Transport
Small GTPase Binding
Regulation Of Transport
Membrane Organization
Small GTPase-mediated Signal Transduction
Cellular Localization
Regulation Of Vesicle-mediated Transport
Regulation Of Protein Localization
Glutamatergic Synapse
Endosome
Cytosol
Organelle Organization
Intracellular Transport
Regulation Of Organelle Organization
Establishment Of Localization In Cell
Protein Targeting
Intracellular Signaling Cassette
Regulation Of Cellular Component Organization
Regulation Of Norepinephrine Uptake
Endosomal Transport
Regulation Of Secretion By Cell
Cytoplasm
Transporter Regulator Activity
Membrane Fusion
Regulation Of Protein Localization To Cell Periphery
Intracellular Signal Transduction
Regulation Of Protein Transport
Positive Regulation Of Protein Localization
Positive Regulation Of Transport
Regulation Of Secretion
Positive Regulation Of Secretion By Cell
Regulation Of Synaptic Vesicle Recycling
Positive Regulation Of Secretion
Retrograde Transport, Endosome To Golgi
Early Endosome Membrane
Exocytosis
Secretion
Post-Golgi Vesicle-mediated Transport
Negative Regulation Of Exocytosis
Regulation Of Cellular Localization
Nuclear DNA Replication
Localization Within Membrane
Regulation Of Establishment Of Protein Localization
Response To Oxidative Stress
Cellular Component Assembly
Regulation Of Protein Localization To Plasma Membrane
Tau Protein Binding
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