RAB4A and RABEP1

Number of citations of the paper that reports this interaction (PubMedID 9524117)
37

Data Source:
HPRD (in vitro, in vivo)

		RAB4A	RABEP1
Description		RAB4A, member RAS oncogene family	rabaptin, RAB GTPase binding effector protein 1
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GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse	Cytoplasm Endosome Early Endosome Cytosol Endocytic Vesicle Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Recycling Endosome Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding	GTPase Activator Activity Protein Binding Growth Factor Activity Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Vesicle-mediated Transport In Synapse	Golgi To Plasma Membrane Transport Endocytosis Apoptotic Process Signal Transduction Protein Transport Vesicle-mediated Transport Membrane Fusion Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Protein Localization To Ciliary Membrane
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling	TBC/RABGAPs
Drugs
Diseases
GWAS		Aging ( 22773346) Heel bone mineral density x serum urate levels interaction ( 34046847) Leukoderma in response to rhododendrol ( 32558222) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)	Body mass index ( 25673413 28892062) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Red blood cell density in sickle cell anemia ( 28552477) White blood cell count ( 27863252)
Interacting Genes		33 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 GARIN6 GDI2 GRIPAP1 HACE1 IDH3A KCTD7 KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABGAP1 RABGEF1 RBSN RUFY1 SNCA SOD2 STX4 TP53 VPS52 ZNF830	60 interacting genes: ABI2 AIMP2 AP1G1 AP1G2 ATXN7 BARD1 CASP3 CCDC120 CCND1 CDC73 CDK18 CDKL3 CEP57 CFAP53 ELOA ESCO2 FAM50B FAM90A1 GAP43 GGA1 GGA2 GGA3 HUNK ITSN1 LENG1 MAT2B MCRS1 NRIP1 ODAD3 PELI2 PKP2 PRPF3 RAB1A RAB33B RAB4A RAB4B RAB5A RABGEF1 RGS17 RNF39 SMURF1 SNAPIN SNCA SNW1 SRPK2 STAR TNS4 TRAPPC2L TRIM26 TSC2 TSHZ2 UBC UBTFL1 USP2 UTP14C WASHC3 YWHAG ZNF438 ZNF512B ZNF774
Entrez ID		5867	9135
HPRD ID		01541	04684
Ensembl ID		ENSG00000168118	ENSG00000029725
Uniprot IDs		A0A087WYT5 P20338	B4DMM4 Q15276
PDB IDs		1YU9 1Z0K 2BMD 2BME	1P4U 1TU3 1X79 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Small GTPase Binding Regulation Of Transport Membrane Organization Small GTPase-mediated Signal Transduction Cellular Localization Regulation Of Vesicle-mediated Transport Regulation Of Protein Localization Glutamatergic Synapse Endosome Cytosol Organelle Organization Intracellular Transport Regulation Of Organelle Organization Establishment Of Localization In Cell Protein Targeting Intracellular Signaling Cassette Regulation Of Cellular Component Organization Regulation Of Norepinephrine Uptake Endosomal Transport Regulation Of Secretion By Cell Cytoplasm Transporter Regulator Activity Membrane Fusion Regulation Of Protein Localization To Cell Periphery Intracellular Signal Transduction Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Transport Regulation Of Secretion Positive Regulation Of Secretion By Cell Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Secretion Retrograde Transport, Endosome To Golgi Early Endosome Membrane Exocytosis Secretion Post-Golgi Vesicle-mediated Transport Negative Regulation Of Exocytosis Regulation Of Cellular Localization Nuclear DNA Replication Localization Within Membrane Regulation Of Establishment Of Protein Localization Response To Oxidative Stress Cellular Component Assembly Regulation Of Protein Localization To Plasma Membrane Tau Protein Binding	Intracellular Protein Localization Vesicle-mediated Transport Golgi Vesicle Transport Protein Binding Early Endosome Membrane Protein Transport Establishment Of Protein Localization Endosome Intracellular Transport Regulation Of Vesicle-mediated Transport G Protein Activity Recycling Endosome Cellular Localization Establishment Of Localization In Cell Vesicle-mediated Transport In Synapse Intracellular Protein Transport Rab Protein Signal Transduction Post-Golgi Vesicle-mediated Transport Endosomal Transport Intracellular Vesicle Regulation Of Exocytosis Small GTPase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction GTPase Activity Early Endosome Post-translational Protein Modification Protein Localization To Cell Surface Presynapse Insulin-responsive Compartment Negative Regulation Of Exocytosis Golgi To Plasma Membrane Protein Transport Vacuolar Transport Synaptic Vesicle Endocytosis Cytoplasmic Vesicle Membrane Protein Localization To Organelle Nucleus Secretion Protein Modification Process Secretion By Cell Protein Polyubiquitination Presynaptic Endocytosis Regulation Of MRNA 3'-end Processing Endosome Membrane Protein Localization To Plasma Membrane Positive Regulation Of Translational Initiation Regulation Of Endosome Size Regulation Of Cellular Component Organization Exocytosis AP-1 Adaptor Complex
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