RAB4A and KIF3B

Number of citations of the paper that reports this interaction (PubMedID 12832475)
45

Data Source:
HPRD (in vivo, in vitro)

		RAB4A	KIF3B
Description		RAB4A, member RAS oncogene family	kinesin family member 3B
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GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse	Cytoplasm Centrosome Cytosol Cytoskeleton Kinesin Complex Plus-end Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Membrane Kinesin II Complex Axon Dendrite Midbody Dendrite Cytoplasm Cell Projection Dendritic Spine Synapse Extracellular Exosome Ciliary Tip Postsynapse Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Small GTPase Binding Intraciliary Transport Particle B Binding
	Biological Process	Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Vesicle-mediated Transport In Synapse	Microtubule-based Movement Mitotic Spindle Organization Mitotic Centrosome Separation Determination Of Left/right Symmetry Axo-dendritic Transport Anterograde Axonal Transport Vesicle-mediated Transport Protein-containing Complex Localization Positive Regulation Of Cytokinesis Opsin Transport Intraciliary Transport Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Mitotic Spindle Assembly Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling	Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS		Aging ( 22773346) Heel bone mineral density x serum urate levels interaction ( 34046847) Leukoderma in response to rhododendrol ( 32558222) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)	Age at first sexual intercourse ( 27089180 34211149) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252)
Interacting Genes		33 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 GARIN6 GDI2 GRIPAP1 HACE1 IDH3A KCTD7 KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABGAP1 RABGEF1 RBSN RUFY1 SNCA SOD2 STX4 TP53 VPS52 ZNF830	12 interacting genes: APP IFT20 KIF3A KIFAP3 LMO2 LMO4 MAP3K10 MAP3K11 NEDD4L PRC1 RAB4A SASH1
Entrez ID		5867	9371
HPRD ID		01541	04781
Ensembl ID		ENSG00000168118	ENSG00000101350
Uniprot IDs		A0A087WYT5 P20338	O15066
PDB IDs		1YU9 1Z0K 2BMD 2BME	3B6U
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Small GTPase Binding Regulation Of Transport Membrane Organization Small GTPase-mediated Signal Transduction Cellular Localization Regulation Of Vesicle-mediated Transport Regulation Of Protein Localization Glutamatergic Synapse Endosome Cytosol Organelle Organization Intracellular Transport Regulation Of Organelle Organization Establishment Of Localization In Cell Protein Targeting Intracellular Signaling Cassette Regulation Of Cellular Component Organization Regulation Of Norepinephrine Uptake Endosomal Transport Regulation Of Secretion By Cell Cytoplasm Transporter Regulator Activity Membrane Fusion Regulation Of Protein Localization To Cell Periphery Intracellular Signal Transduction Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Transport Regulation Of Secretion Positive Regulation Of Secretion By Cell Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Secretion Retrograde Transport, Endosome To Golgi Early Endosome Membrane Exocytosis Secretion Post-Golgi Vesicle-mediated Transport Negative Regulation Of Exocytosis Regulation Of Cellular Localization Nuclear DNA Replication Localization Within Membrane Regulation Of Establishment Of Protein Localization Response To Oxidative Stress Cellular Component Assembly Regulation Of Protein Localization To Plasma Membrane Tau Protein Binding	Positive Regulation Of JUN Kinase Activity Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of MAP Kinase Activity Kinesin II Complex Spindle Microtubule Ciliary Tip Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Positive Regulation Of Protein Serine/threonine Kinase Activity Plus-end-directed Vesicle Transport Along Microtubule Plus-end-directed Organelle Transport Along Microtubule Plasma Membrane Bounded Cell Projection Organization Microtubule-based Transport Regulation Of MAP Kinase Activity JUN Kinase Kinase Kinase Activity Axo-dendritic Transport Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of JNK Cascade Cell Projection Organization Positive Regulation Of Catalytic Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Microtubule-based Movement MAP Kinase Kinase Kinase Activity Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation BHLH Transcription Factor Binding Positive Regulation Of MAPK Cascade Neuron Projection Development Kinesin Binding Photoreceptor Connecting Cilium Regulation Of Catalytic Activity Vesicle Transport Along Microtubule Kinesin Complex Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Receptor Localization To Synapse Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Microtubule Cytoskeleton
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