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RAB7A and RNF115
Number of citations of the paper that reports this interaction (PubMedID
12972561
)
39
Data Source:
HPRD
(in vivo, in vitro)
RAB7A
RNF115
Description
RAB7A, member RAS oncogene family
ring finger protein 115
Image
No pdb structure
GO Annotations
Cellular Component
Autophagosome Membrane
Cytoplasm
Mitochondrion
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Golgi Apparatus
Lipid Droplet
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Secretory Granule Membrane
Phagocytic Vesicle Membrane
Synaptic Vesicle Membrane
Retromer Complex
Cytoplasmic Vesicle
Late Endosome Membrane
Mitochondrial Membrane
Melanosome Membrane
Phagophore Assembly Site Membrane
Phagocytic Vesicle
Extracellular Exosome
Alveolar Lamellar Body
Bounding Membrane Of Organelle
Presynaptic Endosome
Glutamatergic Synapse
Nucleus
Cytoplasm
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Molecular Function
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Small GTPase Binding
Retromer Complex Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Autophagosome Assembly
Protein Targeting To Lysosome
Lipid Metabolic Process
Endocytosis
Autophagy
Epidermal Growth Factor Catabolic Process
Endosome To Lysosome Transport
Response To Bacterium
Protein Transport
Lipid Catabolic Process
Viral Release From Host Cell
Protein To Membrane Docking
Synaptic Vesicle Recycling Via Endosome
Retrograde Transport, Endosome To Golgi
Early Endosome To Late Endosome Transport
Bone Resorption
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Viral Process
Establishment Of Vesicle Localization
Protein Localization To Lysosome
Lipophagy
Phagosome Maturation
Phagosome Acidification
Phagosome-lysosome Fusion
Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome
Vesicle-mediated Transport In Synapse
Endosome To Plasma Membrane Protein Transport
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Exosomal Secretion
Negative Regulation Of Intralumenal Vesicle Formation
Protein Polyubiquitination
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Golgi To Plasma Membrane Transport
Protein Ubiquitination
Negative Regulation Of Toll-like Receptor Signaling Pathway
Positive Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Pathways
MHC class II antigen presentation
Neutrophil degranulation
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RAC3 GTPase cycle
RHOF GTPase cycle
Prevention of phagosomal-lysosomal fusion
Suppression of autophagy
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Guanosine-5'-Diphosphate
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Body fat mass (
28552196
)
Facial morphology traits (63 three-dimensional facial segments) (
29459680
)
Apolipoprotein A1 levels (
32203549
)
Breast cancer (
25751625
29059683
)
HDL cholesterol levels (
32203549
)
Platelet distribution width (
32888494
)
Interacting Genes
24 interacting genes:
CHM
KRTAP10-3
KRTAP10-9
PPP2R1A
PPP2R1B
PRKN
RAB13
RAB17
RAB22A
RAB4A
RAB4B
RAB6A
RABAC1
RABGGTB
RILP
RNF115
RNF167
SLC2A4
TP53
UCHL5
VPS11
VPS16
VPS18
VPS41
34 interacting genes:
AKT1
APP
ATN1
CDK10
CST3
DAZAP2
DOCK4
EGFR
FOLR3
HRAS
IGHA1
MAVS
MDM2
MDM4
MFAP4
NFKBIA
RAB7A
RAD23A
RPL18A
STING1
TTR
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2I
UBE2N
USP9X
VCP
ZNRD2
Entrez ID
7879
27246
HPRD ID
03805
18328
Ensembl ID
ENSG00000075785
ENSG00000265491
Uniprot IDs
A0A158RFU6
P51149
Q9Y4L5
PDB IDs
1T91
1YHN
3LAW
6IYB
6WCW
7F6J
8KB8
8ZQ3
Enriched GO Terms of Interacting Partners
?
Vesicle-mediated Transport
Intracellular Transport
Endosomal Vesicle Fusion
Cellular Localization
Establishment Of Localization In Cell
Insulin-responsive Compartment
Protein Transport
Endosome
HOPS Complex
Regulation Of SNARE Complex Assembly
Establishment Of Protein Localization
Intracellular Protein Transport
Endosome To Lysosome Transport
Vesicle Organization
Lysosomal Transport
Intracellular Protein Localization
Cytoplasmic Vesicle
CORVET Complex
Clathrin-coated Vesicle
Endosomal Transport
Endosome Organization
Late Endosome
Endomembrane System
Vacuolar Transport
Golgi Vesicle Transport
Vesicle Fusion
Organelle Membrane Fusion
Organelle Organization
Organelle Fusion
Recycling Endosome
Membrane Fusion
Late Endosome Membrane
Endosome Membrane
Cytosol
Autophagy
Rab-protein Geranylgeranyltransferase Complex
Rab Geranylgeranyltransferase Activity
Organelle Localization
Meiotic Sister Chromatid Cohesion, Centromeric
Membrane Organization
Vesicle Tethering Complex
GTPase Activity
Early Endosome
GTP Binding
Protein Geranylgeranylation
Lysosomal Membrane
Presynapse
Protein Prenylation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Meiotic Sister Chromatid Cohesion
Ubiquitin Conjugating Enzyme Activity
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Regulation Of Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Protein Modification Process
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Macromolecule Catabolic Process
Nucleotide Binding
Protein Metabolic Process
Protein Monoubiquitination
Protein Serine/threonine Kinase Binding
Ubiquitin Protein Ligase Binding
Positive Regulation Of Cell Cycle G1/S Phase Transition
Protein-containing Complex
Positive Regulation Of Mitotic Cell Cycle
Proteolysis
Positive Regulation Of Mitotic Cell Cycle Phase Transition
ATP Binding
Regulation Of Metabolic Process
Positive Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Cell Cycle
Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Proteolysis
Positive Regulation Of Intracellular Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Enzyme Binding
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Cilium Assembly
Protein K63-linked Ubiquitination
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Immune Response-regulating Signaling Pathway
Regulation Of Intracellular Signal Transduction
Transferase Activity
Activation Of Immune Response
Protein K6-linked Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Traversing Start Control Point Of Mitotic Cell Cycle
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Tagcloud (Intersection)
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