RAB4A and RABGAP1

Number of citations of the paper that reports this interaction (PubMedID 37232246)
61

Data Source:
BioGRID (proximity labelling technology, proximity labelling technology, two hybrid)

		RAB4A	RABGAP1
Description		RAB4A, member RAS oncogene family	RAB GTPase activating protein 1
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GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Associated Complex
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding	GTPase Activator Activity Protein Binding Tubulin Binding Small GTPase Binding
	Biological Process	Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Vesicle-mediated Transport In Synapse	Regulation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling	TBC/RABGAPs
Drugs
Diseases
GWAS		Aging ( 22773346) Heel bone mineral density x serum urate levels interaction ( 34046847) Leukoderma in response to rhododendrol ( 32558222) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)	Birth weight ( 31043758) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878)
Interacting Genes		33 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 GARIN6 GDI2 GRIPAP1 HACE1 IDH3A KCTD7 KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABGAP1 RABGEF1 RBSN RUFY1 SNCA SOD2 STX4 TP53 VPS52 ZNF830	10 interacting genes: CARM1 DISC1 GABARAPL1 MAP1LC3A RAB4A RAB6A RAB6B SENP1 SENP5 STAT3
Entrez ID		5867	23637
HPRD ID		01541	06575
Ensembl ID		ENSG00000168118	ENSG00000011454
Uniprot IDs		A0A087WYT5 P20338	B7Z2B4 Q9Y3P9
PDB IDs		1YU9 1Z0K 2BMD 2BME	4NC6
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Small GTPase Binding Regulation Of Transport Membrane Organization Small GTPase-mediated Signal Transduction Cellular Localization Regulation Of Vesicle-mediated Transport Regulation Of Protein Localization Glutamatergic Synapse Endosome Cytosol Organelle Organization Intracellular Transport Regulation Of Organelle Organization Establishment Of Localization In Cell Protein Targeting Intracellular Signaling Cassette Regulation Of Cellular Component Organization Regulation Of Norepinephrine Uptake Endosomal Transport Regulation Of Secretion By Cell Cytoplasm Transporter Regulator Activity Membrane Fusion Regulation Of Protein Localization To Cell Periphery Intracellular Signal Transduction Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Transport Regulation Of Secretion Positive Regulation Of Secretion By Cell Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Secretion Retrograde Transport, Endosome To Golgi Early Endosome Membrane Exocytosis Secretion Post-Golgi Vesicle-mediated Transport Negative Regulation Of Exocytosis Regulation Of Cellular Localization Nuclear DNA Replication Localization Within Membrane Regulation Of Establishment Of Protein Localization Response To Oxidative Stress Cellular Component Assembly Regulation Of Protein Localization To Plasma Membrane Tau Protein Binding	Glutamatergic Synapse Protein Localization To Golgi Membrane Cellular Response To Nitrogen Starvation SUMO-specific Endopeptidase Activity Protein Desumoylation DeSUMOylase Activity Ciliary Basal Body Phosphatidylethanolamine Binding Myosin V Binding Protein Localization To Golgi Apparatus Presynaptic Cytosol Postsynaptic Cytosol Intra-Golgi Vesicle-mediated Transport Protein Localization To Organelle Endomembrane System Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Regulation Of Erythrocyte Differentiation Autophagosome Maturation Protein Sumoylation Autophagosome Membrane Mitophagy Peptidyl-cysteine Methylation GTPase Activity Microtubule Autophagy Of Mitochondrion Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome GTP Binding Cytoplasmic Vesicle Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Histone H3R2 Methyltransferase Activity Histone H3R17 Methyltransferase Activity Autophagosome Hydrolase Activity Antigen Processing And Presentation Retrograde Transport, Endosome To Golgi Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Histone Arginine N-methyltransferase Activity Autophagosome Organization Autophagosome Assembly Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Regulation Of Definitive Erythrocyte Differentiation Intracellular Protein Localization Positive Regulation Of MRNA Catabolic Process Protein Modification By Small Protein Removal Phospholipid Binding Minus-end-directed Organelle Transport Along Microtubule
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