RAB7A and RAB4B

Number of citations of the paper that reports this interaction (PubMedID 10329441)
0

Data Source:
BioGRID (two hybrid)

		RAB7A	RAB4B
Description		RAB7A, member RAS oncogene family	RAB4B, member RAS oncogene family
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GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Retromer Complex Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome Alveolar Lamellar Body Bounding Membrane Of Organelle Presynaptic Endosome Glutamatergic Synapse	Endosome Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Early Endosome Membrane Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Retromer Complex Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Autophagosome Assembly Protein Targeting To Lysosome Lipid Metabolic Process Endocytosis Autophagy Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Response To Bacterium Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Synaptic Vesicle Recycling Via Endosome Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Bone Resorption Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Protein Localization To Lysosome Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Endosome To Plasma Membrane Protein Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation	Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Rab Protein Signal Transduction Endosomal Vesicle Fusion Early Endosome To Golgi Transport D-glucose Import
Pathways		MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy	Neutrophil degranulation RAB geranylgeranylation MET receptor recycling
Drugs		Guanosine-5'-Diphosphate
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)	Carotid intima media thickness (mean) ( 31801372) Chronic obstructive pulmonary disease ( 22080838 28166215) Emphysema imaging phenotypes ( 26030696) Eosinophil percentage of white cells ( 32888494) Hematocrit ( 32888494) Hemoglobin ( 32888494) Kawasaki disease ( 22081228) Red blood cell count ( 32888494) Smoking behaviour (cigarettes smoked per day) ( 30617275)
Interacting Genes		24 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RNF167 SLC2A4 TP53 UCHL5 VPS11 VPS16 VPS18 VPS41	9 interacting genes: BOLA2 BOLA2B CDC45 EXOC5 GARIN6 RAB7A RABAC1 RABEP1 VPS52
Entrez ID		7879	53916
HPRD ID		03805	11473
Ensembl ID		ENSG00000075785	ENSG00000167578
Uniprot IDs		A0A158RFU6 P51149	P61018
PDB IDs		1T91 1YHN 3LAW 6IYB 6WCW 7F6J 8KB8 8ZQ3	2O52
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Transport Endosomal Vesicle Fusion Cellular Localization Establishment Of Localization In Cell Insulin-responsive Compartment Protein Transport Endosome HOPS Complex Regulation Of SNARE Complex Assembly Establishment Of Protein Localization Intracellular Protein Transport Endosome To Lysosome Transport Vesicle Organization Lysosomal Transport Intracellular Protein Localization Cytoplasmic Vesicle CORVET Complex Clathrin-coated Vesicle Endosomal Transport Endosome Organization Late Endosome Endomembrane System Vacuolar Transport Golgi Vesicle Transport Vesicle Fusion Organelle Membrane Fusion Organelle Organization Organelle Fusion Recycling Endosome Membrane Fusion Late Endosome Membrane Endosome Membrane Cytosol Autophagy Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Organelle Localization Meiotic Sister Chromatid Cohesion, Centromeric Membrane Organization Vesicle Tethering Complex GTPase Activity Early Endosome GTP Binding Protein Geranylgeranylation Lysosomal Membrane Presynapse Protein Prenylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Meiotic Sister Chromatid Cohesion	Vesicle-mediated Transport To The Plasma Membrane Post-Golgi Vesicle-mediated Transport Iron-sulfur Cluster Assembly Complex [2Fe-2S] Cluster Assembly Iron-sulfur Cluster Assembly 2 Iron, 2 Sulfur Cluster Binding Localization Within Membrane Protein Localization To Cell Periphery Cell Redox Homeostasis Golgi Vesicle Transport Embryonic Ectodermal Digestive Tract Development Synaptic Vesicle Recycling Via Endosome Protein Localization To Membrane Mitotic DNA Replication Preinitiation Complex Assembly Golgi To Plasma Membrane Transport Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Binding Endocytic Recycling Negative Regulation Of Intralumenal Vesicle Formation Membrane Docking Epidermal Growth Factor Catabolic Process Intracellular Monoatomic Ion Homeostasis Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Intracellular Monoatomic Cation Homeostasis DNA Replication Preinitiation Complex Retrograde Transport, Endosome To Golgi Protein Transport Monoatomic Cation Homeostasis Lipophagy DNA Replication Preinitiation Complex Assembly Monoatomic Ion Homeostasis Lysosomal Transport Cytosolic Transport Vesicle-mediated Transport Negative Regulation Of Exosomal Secretion Intracellular Chemical Homeostasis Recycling Endosome GARP Complex EARP Complex Ectodermal Cell Differentiation Protein To Membrane Docking Glutamatergic Synapse Regulation Of Endosome Organization Membrane Fusion Establishment Of Protein Localization Alveolar Lamellar Body Vacuolar Transport Cellular Homeostasis Phagosome Acidification Membrane Organization
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