RAB7A and RAB4B

Number of citations of the paper that reports this interaction (PMID 10329441)
15

Data Source:
BioGRID (two hybrid)

		RAB7A	RAB4B
Gene Name		RAB7A, member RAS oncogene family	RAB4B, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Late Endosome Vacuolar Membrane Golgi Apparatus Phagocytic Vesicle Membrane Retromer Complex Pre-autophagosomal Structure Membrane Melanosome Intracellular Membrane-bounded Organelle Phagocytic Vesicle Extracellular Vesicular Exosome Alveolar Lamellar Body	Plasma Membrane Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Rac GTPase Binding	Molecular_function GTPase Activity GTP Binding GDP Binding
	Biological Process	Protein Targeting To Lysosome Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein To Membrane Docking Rab Protein Signal Transduction Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Bone Resorption Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Positive Regulation Of Exosomal Secretion Regulation Of Autophagic Vacuole Assembly	Intracellular Protein Transport Regulation Of Endocytosis Rab Protein Signal Transduction Glucose Import
Pathways		MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease ( 22080838)
Protein-Protein Interactions		18 interactors: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B RAB17 RAB22A RAB4A RAB4B RAB5A RAB5B RAB6A RABAC1 RABGGTB RILP RNF115 SLC2A4 UCHL5	3 interactors: EXOC5 RAB7A RABAC1
Entrez ID		7879	53916
HPRD ID		03805	11473
Ensembl ID		ENSG00000075785	ENSG00000167578
Uniprot IDs		C9J4V0 C9J8S3 P51149	P61018
PDB IDs		1T91 1YHN 3LAW	2O52
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Ras Protein Signal Transduction Intracellular Protein Transport Cellular Protein Localization Protein Transport Small GTPase Mediated Signal Transduction Establishment Of Protein Localization Intracellular Transport Regulation Of Endocytosis Endosomal Transport Protein Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Cellular Localization Intracellular Signal Transduction Protein Geranylgeranylation Glucose Import Antigen Processing And Presentation Protein Prenylation Transport Endosome Organization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Filopodium Assembly Amylopectin Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Regulation Of Cellular Component Organization Cytoplasmic Transport Glucose Transport Hexose Transport Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Peptidyl-serine Dephosphorylation Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Regulation Of Vesicle Size Vesicle-mediated Transport Signal Transduction Membrane Organization Cellular Response To Stimulus Receptor Internalization Involved In Canonical Wnt Signaling Pathway Minus-end-directed Organelle Transport Along Microtubule Peptidyl-cysteine Methylation Regulation Of Endosome Size Protein Targeting Response To Stimulus Endomembrane System Organization Regulation Of Cell Projection Assembly Immunoglobulin Transcytosis In Epithelial Cells Signaling Carbohydrate Transport Cell Communication	Membrane Docking Epidermal Growth Factor Catabolic Process Phagosome-lysosome Fusion Phagosome Acidification Protein To Membrane Docking Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Phagolysosome Assembly Protein Localization To Lysosome Regulation Of Autophagic Vacuole Assembly Membrane Organization Regulation Of Vacuole Organization Intracellular PH Reduction Early Endosome To Late Endosome Transport PH Reduction Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Endosome To Lysosome Transport Bone Resorption Protein Transport Phagosome Maturation Regulation Of Intracellular PH Vesicle-mediated Transport Lysosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization Regulation Of Cellular PH Negative Regulation Of ERBB Signaling Pathway Intracellular Transport Vesicle Fusion Lysosome Organization Bone Remodeling Rab Protein Signal Transduction Positive Regulation Of Exocytosis Retrograde Transport, Endosome To Golgi Regulation Of PH Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Fusion Vacuolar Transport Protein Localization Vesicle Docking Regulation Of ERBB Signaling Pathway Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Vacuole Organization Regulation Of Autophagy
Tagcloud ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab5a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly	adaptor ap1gamma budding characterised clathrin coated endocytic endosome endosomes fyve gtpases homeostasis internalised naturally perturbed rab11 reach recycled recycling sorting tf tfr tfrs traffic transferrin uncover vamp3 vesicles
Tagcloud (Difference) ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi liposomes localize master membrane organelles rab2a rab5a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly	adaptor ap1gamma budding characterised clathrin coated endocytic endosome endosomes fyve homeostasis internalised naturally perturbed rab11 reach recycled recycling sorting tf tfr tfrs traffic transferrin uncover vamp3 vesicles
Tagcloud (Intersection) ?		gtpases