RAB4A and APBB3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		RAB4A	APBB3
Description		RAB4A, member RAS oncogene family	amyloid beta precursor protein binding family B member 3
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GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Actin Cytoskeleton Membrane Nuclear Body
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding	Amyloid-beta Binding Protein Binding Low-density Lipoprotein Particle Receptor Binding Molecular Adaptor Activity
	Biological Process	Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Vesicle-mediated Transport In Synapse	Regulation Of DNA-templated Transcription Positive Regulation Of Protein Secretion
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling
Drugs
Diseases
GWAS		Aging ( 22773346) Heel bone mineral density x serum urate levels interaction ( 34046847) Leukoderma in response to rhododendrol ( 32558222) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)	Serum immune biomarker levels ( 32066700)
Interacting Genes		33 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 GARIN6 GDI2 GRIPAP1 HACE1 IDH3A KCTD7 KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABGAP1 RABGEF1 RBSN RUFY1 SNCA SOD2 STX4 TP53 VPS52 ZNF830	6 interacting genes: APLP2 APP EGFR ERBB2 PDPK1 RAB4A
Entrez ID		5867	10307
HPRD ID		01541	04089
Ensembl ID		ENSG00000168118	ENSG00000113108
Uniprot IDs		A0A087WYT5 P20338	O95704 Q59EH2 Q96DX9
PDB IDs		1YU9 1Z0K 2BMD 2BME	2DYQ 2YSC
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Small GTPase Binding Regulation Of Transport Membrane Organization Small GTPase-mediated Signal Transduction Cellular Localization Regulation Of Vesicle-mediated Transport Regulation Of Protein Localization Glutamatergic Synapse Endosome Cytosol Organelle Organization Intracellular Transport Regulation Of Organelle Organization Establishment Of Localization In Cell Protein Targeting Intracellular Signaling Cassette Regulation Of Cellular Component Organization Regulation Of Norepinephrine Uptake Endosomal Transport Regulation Of Secretion By Cell Cytoplasm Transporter Regulator Activity Membrane Fusion Regulation Of Protein Localization To Cell Periphery Intracellular Signal Transduction Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Transport Regulation Of Secretion Positive Regulation Of Secretion By Cell Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Secretion Retrograde Transport, Endosome To Golgi Early Endosome Membrane Exocytosis Secretion Post-Golgi Vesicle-mediated Transport Negative Regulation Of Exocytosis Regulation Of Cellular Localization Nuclear DNA Replication Localization Within Membrane Regulation Of Establishment Of Protein Localization Response To Oxidative Stress Cellular Component Assembly Regulation Of Protein Localization To Plasma Membrane Tau Protein Binding	Intracellular Signaling Cassette Response To Growth Factor Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus ERBB Signaling Pathway Response To Epidermal Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB2-EGFR Signaling Pathway Transition Metal Ion Binding Platelet Alpha Granule Early Endosome Membrane Receptor Complex Positive Regulation Of Epithelial Cell Proliferation ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Perinuclear Region Of Cytoplasm Endosome Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phosphate Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Localization Receptor Localization To Synapse Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Epithelial Cell Proliferation Glial Cell Development Basal Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Signal Transduction Positive Regulation Of Intracellular Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Cell Periphery Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Multivesicular Body, Internal Vesicle Lumen 3-phosphoinositide-dependent Protein Kinase Activity Positive Regulation Of MAPK Cascade Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Protein Localization To Membrane Regulation Of MiRNA Metabolic Process Protein Kinase Activity Ruffle Membrane Regulation Of Cellular Localization
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