RAB7A and VPS18

Number of citations of the paper that reports this interaction (PubMedID 34432599)
51

Data Source:
BioGRID (pull down, affinity chromatography technology, proximity labelling technology)

		RAB7A	VPS18
Description		RAB7A, member RAS oncogene family	VPS18 core subunit of CORVET and HOPS complexes
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Retromer Complex Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome Alveolar Lamellar Body Bounding Membrane Of Organelle Presynaptic Endosome Glutamatergic Synapse	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Actin Filament Endosome Membrane Endomembrane System Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Presynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Retromer Complex Binding	Actin Binding Protein Binding Zinc Ion Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Autophagosome Assembly Protein Targeting To Lysosome Lipid Metabolic Process Endocytosis Autophagy Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Response To Bacterium Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Synaptic Vesicle Recycling Via Endosome Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Bone Resorption Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Protein Localization To Lysosome Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Endosome To Plasma Membrane Protein Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Protein Ubiquitination Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Symbiont Entry Into Host Cell Organelle Fusion Regulation Of Synaptic Vesicle Exocytosis
Pathways		MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy	SARS-CoV-2 modulates autophagy
Drugs		Guanosine-5'-Diphosphate
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)	Hemoglobin ( 32888494) Malaria ( 31844061) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		24 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RNF167 SLC2A4 TP53 UCHL5 VPS11 VPS16 VPS18 VPS41	22 interacting genes: AKTIP COPB1 EP300 GGA1 GGA2 GGA3 HOOK1 MON1B PLEKHM1 RAB7A RILP SHANK3 STX1A STX6 STX7 STX8 UBE2D2 UVRAG VPS11 VPS16 VPS33A VPS45
Entrez ID		7879	57617
HPRD ID		03805	09776
Ensembl ID		ENSG00000075785	ENSG00000104142
Uniprot IDs		A0A158RFU6 P51149	Q9P253
PDB IDs		1T91 1YHN 3LAW 6IYB 6WCW 7F6J 8KB8 8ZQ3
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Transport Endosomal Vesicle Fusion Cellular Localization Establishment Of Localization In Cell Insulin-responsive Compartment Protein Transport Endosome HOPS Complex Regulation Of SNARE Complex Assembly Establishment Of Protein Localization Intracellular Protein Transport Endosome To Lysosome Transport Vesicle Organization Lysosomal Transport Intracellular Protein Localization Cytoplasmic Vesicle CORVET Complex Clathrin-coated Vesicle Endosomal Transport Endosome Organization Late Endosome Endomembrane System Vacuolar Transport Golgi Vesicle Transport Vesicle Fusion Organelle Membrane Fusion Organelle Organization Organelle Fusion Recycling Endosome Membrane Fusion Late Endosome Membrane Endosome Membrane Cytosol Autophagy Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Organelle Localization Meiotic Sister Chromatid Cohesion, Centromeric Membrane Organization Vesicle Tethering Complex GTPase Activity Early Endosome GTP Binding Protein Geranylgeranylation Lysosomal Membrane Presynapse Protein Prenylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Meiotic Sister Chromatid Cohesion	Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Intracellular Transport Cellular Localization Establishment Of Localization In Cell Establishment Of Protein Localization Intracellular Protein Transport Endosome Vesicle Organization Vesicle Fusion Organelle Membrane Fusion Vacuolar Transport Lysosomal Transport Organelle Fusion Membrane Fusion Late Endosome Endosome To Lysosome Transport Endosome Membrane Early Endosome HOPS Complex Endosomal Transport Early Endosome To Late Endosome Transport Membrane Organization Lysosome Late Endosome Membrane Membrane Docking Cytoplasmic Vesicle Organelle Localization Vesicle Docking Lysosomal Membrane SNARE Binding Recycling Endosome Organelle Organization Clathrin-coated Vesicle Organelle Localization By Membrane Tethering Chloride Channel Inhibitor Activity Endosome Organization CORVET Complex Phagocytic Vesicle Vacuole Organization SNAP Receptor Activity SNARE Complex Syntaxin Binding Vesicle-mediated Transport To The Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Golgi Vesicle Transport Autophagy
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