RAB7A and RAB22A

Number of citations of the paper that reports this interaction (PubMedID 10329441)
0

Data Source:
BioGRID (two hybrid)

		RAB7A	RAB22A
Description		RAB7A, member RAS oncogene family	RAB22A, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Retromer Complex Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome Alveolar Lamellar Body Bounding Membrane Of Organelle Presynaptic Endosome Glutamatergic Synapse	Ruffle Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Endomembrane System Actin Cytoskeleton Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Retromer Complex Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Autophagosome Assembly Protein Targeting To Lysosome Lipid Metabolic Process Endocytosis Autophagy Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Response To Bacterium Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Synaptic Vesicle Recycling Via Endosome Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Bone Resorption Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Protein Localization To Lysosome Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Endosome To Plasma Membrane Protein Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Regulation Of Vesicle Size
Pathways		MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy	RAB geranylgeranylation
Drugs		Guanosine-5'-Diphosphate
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)	Appendicular lean mass ( 33097823) Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Metabolite levels ( 23823483) Nickel levels ( 26025379)
Interacting Genes		24 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RNF167 SLC2A4 TP53 UCHL5 VPS11 VPS16 VPS18 VPS41	7 interacting genes: ALS2CL APPL2 EEA1 RAB3GAP1 RAB7A RABAC1 SMURF2
Entrez ID		7879	57403
HPRD ID		03805	06696
Ensembl ID		ENSG00000075785	ENSG00000124209
Uniprot IDs		A0A158RFU6 P51149	Q9UL26
PDB IDs		1T91 1YHN 3LAW 6IYB 6WCW 7F6J 8KB8 8ZQ3
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Transport Endosomal Vesicle Fusion Cellular Localization Establishment Of Localization In Cell Insulin-responsive Compartment Protein Transport Endosome HOPS Complex Regulation Of SNARE Complex Assembly Establishment Of Protein Localization Intracellular Protein Transport Endosome To Lysosome Transport Vesicle Organization Lysosomal Transport Intracellular Protein Localization Cytoplasmic Vesicle CORVET Complex Clathrin-coated Vesicle Endosomal Transport Endosome Organization Late Endosome Endomembrane System Vacuolar Transport Golgi Vesicle Transport Vesicle Fusion Organelle Membrane Fusion Organelle Organization Organelle Fusion Recycling Endosome Membrane Fusion Late Endosome Membrane Endosome Membrane Cytosol Autophagy Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Organelle Localization Meiotic Sister Chromatid Cohesion, Centromeric Membrane Organization Vesicle Tethering Complex GTPase Activity Early Endosome GTP Binding Protein Geranylgeranylation Lysosomal Membrane Presynapse Protein Prenylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Meiotic Sister Chromatid Cohesion	Cytoplasmic Vesicle Presynaptic Endosome Bounding Membrane Of Organelle Early Endosome To Late Endosome Transport Cellular Localization Endosomal Transport Small GTPase Binding Establishment Of Protein Localization To Organelle Organelle Membrane Fusion Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Lipid Droplet Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle Fusion Phagocytic Vesicle Synaptic Vesicle Recycling Via Endosome Phagocytic Vesicle Membrane Intracellular Transport Axonal Spine Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Lipophagy Glutamatergic Synapse Organelle Fusion Regulation Of Vesicle-mediated Transport Synaptic Vesicle To Endosome Fusion Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Early Phagosome Membrane Cold Acclimation Negative Regulation Of Exosomal Secretion Membrane Fusion Postsynaptic Early Endosome Chemical Synaptic Transmission, Postsynaptic Positive Regulation Of Protein Lipidation Positive Regulation Of Glutamate Secretion, Neurotransmission Cytoplasm Protein To Membrane Docking Establishment Of Localization In Cell Regulation Of Endosome Organization Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Glutamate Secretion, Neurotransmission Macropinosome Regulation Of Exocytosis Alveolar Lamellar Body Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Endosome Phagosome Acidification
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