RAB7A and RAB22A

Number of citations of the paper that reports this interaction (PMID 10329441)
15

Data Source:
BioGRID (two hybrid)

		RAB7A	RAB22A
Gene Name		RAB7A, member RAS oncogene family	RAB22A, member RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Late Endosome Vacuolar Membrane Golgi Apparatus Phagocytic Vesicle Membrane Retromer Complex Pre-autophagosomal Structure Membrane Melanosome Intracellular Membrane-bounded Organelle Phagocytic Vesicle Extracellular Vesicular Exosome Alveolar Lamellar Body	Ruffle Early Endosome Plasma Membrane Endosome Membrane Actin Cytoskeleton Phagocytic Vesicle Membrane Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Rac GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Protein Targeting To Lysosome Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein To Membrane Docking Rab Protein Signal Transduction Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Bone Resorption Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Positive Regulation Of Exosomal Secretion Regulation Of Autophagic Vacuole Assembly	Intracellular Protein Transport Endocytosis Endosome Organization Rab Protein Signal Transduction Regulation Of Vesicle Size
Pathways		MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B RAB17 RAB22A RAB4A RAB4B RAB5A RAB5B RAB6A RABAC1 RABGGTB RILP RNF115 SLC2A4 UCHL5	6 interactors: APPL2 EEA1 RAB3GAP1 RAB7A RABAC1 SMURF2
Entrez ID		7879	57403
HPRD ID		03805	06696
Ensembl ID		ENSG00000075785	ENSG00000124209
Uniprot IDs		C9J4V0 C9J8S3 P51149	Q9UL26
PDB IDs		1T91 1YHN 3LAW
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Ras Protein Signal Transduction Intracellular Protein Transport Cellular Protein Localization Protein Transport Small GTPase Mediated Signal Transduction Establishment Of Protein Localization Intracellular Transport Regulation Of Endocytosis Endosomal Transport Protein Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Cellular Localization Intracellular Signal Transduction Protein Geranylgeranylation Glucose Import Antigen Processing And Presentation Protein Prenylation Transport Endosome Organization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Filopodium Assembly Amylopectin Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Regulation Of Cellular Component Organization Cytoplasmic Transport Glucose Transport Hexose Transport Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Peptidyl-serine Dephosphorylation Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Regulation Of Vesicle Size Vesicle-mediated Transport Signal Transduction Membrane Organization Cellular Response To Stimulus Receptor Internalization Involved In Canonical Wnt Signaling Pathway Minus-end-directed Organelle Transport Along Microtubule Peptidyl-cysteine Methylation Regulation Of Endosome Size Protein Targeting Response To Stimulus Endomembrane System Organization Regulation Of Cell Projection Assembly Immunoglobulin Transcytosis In Epithelial Cells Signaling Carbohydrate Transport Cell Communication	Early Endosome To Late Endosome Transport Vesicle Fusion Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Fusion Regulation Of ERBB Signaling Pathway Synaptic Vesicle To Endosome Fusion Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Epidermal Growth Factor Catabolic Process Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Membrane Fusion Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Membrane Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Endosomal Transport Vesicle Organization Signaling Phagosome-lysosome Fusion Cell Communication Regulation Of Signal Transduction Phagosome Acidification Positive Regulation Of Glutamate Secretion Regulation Of Signaling Ubiquitin-dependent SMAD Protein Catabolic Process Protein To Membrane Docking Positive Regulation Of Secretion Establishment Of Protein Localization To Organelle Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Amino Acid Transport Protein Targeting To Lysosome Regulation Of Glutamate Secretion Regulation Of Short-term Neuronal Synaptic Plasticity Lipid Particle Organization Phagolysosome Assembly Protein Localization To Lysosome Cellular Cation Homeostasis Regulation Of Autophagic Vacuole Assembly Positive Regulation Of Neurotransmitter Secretion Forebrain Development Cellular Ion Homeostasis Cellular Copper Ion Homeostasis Regulation Of Vacuole Organization Intracellular PH Reduction Protein Localization To Organelle Protein Targeting To Vacuole PH Reduction Copper Ion Homeostasis Suckling Behavior Cellular Chemical Homeostasis Hypothalamus Development
Tagcloud ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab5a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly	casein cisternae ck2alpha complemented efflux exocytic exome fragmented gap gtpase guanine huh7 ile34phe junction lucifer morphologies pyrophosphatase thiamine trafficking transferrin trf1 trf2 trf4 trf5 trf6 trf7 vsv yellow
Tagcloud (Difference) ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab5a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly	casein cisternae ck2alpha complemented efflux exocytic exome fragmented gap gtpase guanine huh7 ile34phe junction lucifer morphologies pyrophosphatase thiamine trafficking transferrin trf1 trf2 trf4 trf5 trf6 trf7 vsv yellow
Tagcloud (Intersection) ?