RAB7A and RAB6A

Number of citations of the paper that reports this interaction (PubMedID 10329441)
0

Data Source:
BioGRID (two hybrid)

		RAB7A	RAB6A
Description		RAB7A, member RAS oncogene family	RAB6A, member RAS oncogene family
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GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Retromer Complex Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome Alveolar Lamellar Body Bounding Membrane Of Organelle Presynaptic Endosome Glutamatergic Synapse	Golgi Membrane Acrosomal Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Secretory Granule Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Ciliary Basal Body Extracellular Exosome Endosome To Plasma Membrane Transport Vesicle
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Retromer Complex Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding Myosin V Binding
	Biological Process	Autophagosome Assembly Protein Targeting To Lysosome Lipid Metabolic Process Endocytosis Autophagy Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Response To Bacterium Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Synaptic Vesicle Recycling Via Endosome Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Bone Resorption Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Protein Localization To Lysosome Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Endosome To Plasma Membrane Protein Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Peptidyl-cysteine Methylation Antigen Processing And Presentation Neuron Projection Development Protein Localization To Golgi Apparatus Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Minus-end-directed Organelle Transport Along Microtubule Protein Localization To Golgi Membrane
Pathways		MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy	Pre-NOTCH Processing in Golgi Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic Retrograde transport at the Trans-Golgi-Network TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Guanosine-5'-Diphosphate
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)	Dimensional psychopathology (Cognitive) ( 29496196) Obesity-related traits ( 23251661)
Interacting Genes		24 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RNF167 SLC2A4 TP53 UCHL5 VPS11 VPS16 VPS18 VPS41	23 interacting genes: BICD1 BICD2 CHM CHML DCTN1 ERC1 FKBP2 GDI1 GOLGA1 GOLGA2 GOLGA4 GORAB KIF20A OCRL PMM1 RAB7A RABAC1 RABGAP1 RABGGTB SYTL5 TIAM1 TMEM132D TMF1
Entrez ID		7879	5870
HPRD ID		03805	01543
Ensembl ID		ENSG00000075785	ENSG00000175582
Uniprot IDs		A0A158RFU6 P51149	A0A024R5J5 P20340 Q53ET8
PDB IDs		1T91 1YHN 3LAW 6IYB 6WCW 7F6J 8KB8 8ZQ3	1YZQ 2GIL 3BBP 3CWZ 4DKX 5LEF
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Transport Endosomal Vesicle Fusion Cellular Localization Establishment Of Localization In Cell Insulin-responsive Compartment Protein Transport Endosome HOPS Complex Regulation Of SNARE Complex Assembly Establishment Of Protein Localization Intracellular Protein Transport Endosome To Lysosome Transport Vesicle Organization Lysosomal Transport Intracellular Protein Localization Cytoplasmic Vesicle CORVET Complex Clathrin-coated Vesicle Endosomal Transport Endosome Organization Late Endosome Endomembrane System Vacuolar Transport Golgi Vesicle Transport Vesicle Fusion Organelle Membrane Fusion Organelle Organization Organelle Fusion Recycling Endosome Membrane Fusion Late Endosome Membrane Endosome Membrane Cytosol Autophagy Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Organelle Localization Meiotic Sister Chromatid Cohesion, Centromeric Membrane Organization Vesicle Tethering Complex GTPase Activity Early Endosome GTP Binding Protein Geranylgeranylation Lysosomal Membrane Presynapse Protein Prenylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Meiotic Sister Chromatid Cohesion	Small GTPase Binding Golgi Apparatus Vesicle-mediated Transport Rab-protein Geranylgeranyltransferase Complex Protein Geranylgeranylation Cellular Localization Intracellular Transport Protein Prenylation Microtubule Anchoring At Microtubule Organizing Center Protein Transport GDP-dissociation Inhibitor Activity Establishment Of Localization In Cell Establishment Of Protein Localization Microtubule Anchoring Intracellular Protein Localization Minus-end-directed Organelle Transport Along Microtubule Rab Geranylgeranyltransferase Activity GTPase Activator Activity Golgi Vesicle Transport Organelle Assembly Cytosol Trans-Golgi Network Cytoplasm Positive Regulation Of Axonogenesis Microtubule-based Movement Dynactin Binding Microtubule Cytoskeleton Organization Retrograde Transport, Endosome To Golgi Dynein Complex Binding Retromer Complex Cytoskeletal Anchor Activity Small GTPase-mediated Signal Transduction Establishment Of Organelle Localization Microtubule-based Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytosolic Transport Maintenance Of Synapse Structure Vesicle-mediated Transport To The Plasma Membrane Cytoplasmic Vesicle Mitotic Spindle Regulation Of Axonogenesis Microtubule Associated Complex Positive Regulation Of Axon Extension GTPase Binding Synaptic Vesicle Recycling Via Endosome Neuronal Cell Body Regulation Of Microtubule Cytoskeleton Organization Golgi Membrane Transport Along Microtubule Centrosome
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