LRP8 and GRIN1

Number of citations: 0 (PubMedID 16332682)
Data Source: HPRD (in vivo)

		LRP8	GRIN1
Name		LDL receptor related protein 8	glutamate ionotropic receptor NMDA type subunit 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Microtubule Associated Complex Plasma Membrane Caveola Cell Surface Membrane Axon Dendrite Neuronal Cell Body Receptor Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Monoatomic Ion Channel Complex Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane Postsynaptic Density Membrane Neurotransmitter Receptor Complex
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity Metal Ion Binding Calcium-dependent Protein Binding	Amyloid-beta Binding NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Sodium Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Protein-containing Complex Binding Metal Ion Binding Glycine-gated Cation Channel Activity
	Biological Process	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Chemical Synaptic Transmission Response To Xenobiotic Stimulus Cytokine-mediated Signaling Pathway Ventral Spinal Cord Development Ammon Gyrus Development Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Development Reelin-mediated Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development Regulation Of Neuron Migration	Monoatomic Ion Transport Monoatomic Cation Transport Chemical Synaptic Transmission Brain Development Visual Learning Positive Regulation Of Calcium Ion Transport Into Cytosol Propylene Metabolic Process Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Heterotetramerization Positive Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Homeostasis Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Amyloid-beta Response To Glycine Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Platelet sensitization by LDL Retinoid metabolism and transport	EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		None	Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Memantine Orphenadrine Phenobarbital Aripiprazole Prasterone 5,7-Dichlorokynurenic acid D-Serine Cycloleucine Milnacipran CNS-5161 Acetylcysteine Ketobemidone Gavestinel Agmatine Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
GWAS		Blood protein levels ( 30072576 ) Body mass index (alcohol intake interaction) ( 23192594 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cerebrospinal fluid AB1-42 levels ( 28247064 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) General risk tolerance (MTAG) ( 30643258 ) Number of sexual partners ( 30643258 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Type 2 diabetes nephropathy ( 30566433 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )	Post-traumatic stress disorder (asjusted for relatedness) ( 23726511 )
Interacting Genes		21 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP	58 interacting genes: ACTN2 AKAP9 APP BDKRB1 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 NR1H4 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG PTAFR RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B
Entrez ID		7804	2902
HPRD ID		04002	15926
Ensembl ID		ENSG00000157193	ENSG00000176884
Uniprot IDs		Q14114	Q05586 Q59GW0 Q5VSF9
PDB IDs		3A7Q 5B4X 5B4Y 7UCX	2HQW 2NR1 3BYA 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH 7EOQ 7EOR 7EOS 7EOT 7EOU 7EU7 7EU8 7YFF 7YFL 7YFM 7YFO 7YFR 8E92 8E93 8E94 8E96 8E97 8E98 8E99 8JIZ 8JJ0 8JJ1 8JJ2 8UUE 8VUL 8VUN 8VUQ 8VUR 8VUS 8VUT 8VUU 8VUV 8Y1V 9D37 9D38 9D39 9D3A 9D3B 9D3C 9GIB 9GIC 9GID 9GIE 9GIF 9GIG 9GJ1
GO Terms Enriched among Interactors		Low-density Lipoprotein Particle Receptor Binding Amyloid-beta Binding Very-low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Regulation Of Multicellular Organismal Process Receptor Clustering Modulation Of Excitatory Postsynaptic Potential Neurotransmitter-gated Ion Channel Clustering Learning Or Memory Regulation Of Cell Communication Regulation Of Signaling Modulation Of Chemical Synaptic Transmission Cognition Negative Regulation Of MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Amyloid-beta Clearance Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Behavior Regulation Of Biological Quality Locomotory Behavior Negative Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Regulation Of System Process Lateral Motor Column Neuron Migration Regulation Of Synaptic Plasticity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Spinal Cord Motor Neuron Migration Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Cell Projection Organization Positive Regulation Of Amyloid Fibril Formation AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Regulation Of Neuron Projection Development Regulation Of Nervous System Process Regulation Of Membrane Potential Negative Regulation Of Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Receptor Ligand Activity Regulation Of Neurofibrillary Tangle Assembly Signal Transduction Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Modulation Of Chemical Synaptic Transmission Glutamatergic Synapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Biological Quality Regulation Of Synaptic Plasticity Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Synaptic Transmission Chemical Synaptic Transmission Regulation Of Cellular Component Organization Long-term Synaptic Potentiation Neuron Projection Synapse Signaling Postsynaptic Density Membrane Cell Communication Regulation Of Monoatomic Ion Transport Regulation Of Cell Communication Regulation Of Signaling Cell-cell Signaling Regulation Of Transport Synaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Anatomical Structure Morphogenesis Regulation Of Synapse Organization Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Signal Transduction Plasma Membrane Postsynaptic Density Regulation Of Metal Ion Transport Regulation Of Cellular Localization Learning Or Memory Cell Projection Protein Kinase Binding Regulation Of Apoptotic Process Cell Junction Organization NMDA Glutamate Receptor Activity Regulation Of Calcium Ion Transport Dendrite Ligand-gated Ion Channel Signaling Pathway Regulation Of Protein Localization Developmental Process Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cognition