LRP8 and APBA2

Number of citations of the paper that reports this interaction (PubMedID 10827173)
0

Data Source:
BioGRID (two hybrid)

		LRP8	APBA2
Description		LDL receptor related protein 8	amyloid beta precursor protein binding family A member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Microtubule Associated Complex Plasma Membrane Caveola Cell Surface Membrane Axon Dendrite Neuronal Cell Body Receptor Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Plasma Membrane Dendritic Spine Schaffer Collateral - CA1 Synapse Presynapse
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity Metal Ion Binding Calcium-dependent Protein Binding	Amyloid-beta Binding Protein Binding Identical Protein Binding
	Biological Process	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Chemical Synaptic Transmission Response To Xenobiotic Stimulus Cytokine-mediated Signaling Pathway Ventral Spinal Cord Development Ammon Gyrus Development Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Development Reelin-mediated Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development Regulation Of Neuron Migration	In Utero Embryonic Development Chemical Synaptic Transmission Nervous System Development Locomotory Behavior Regulation Of Gene Expression Protein Transport Multicellular Organism Growth Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Platelet sensitization by LDL Retinoid metabolism and transport	Neurexins and neuroligins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index (alcohol intake interaction) ( 23192594) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 28247064) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes nephropathy ( 30566433) Urinary metabolite levels in chronic kidney disease ( 31959995)	Longevity (100 years and older) ( 33948810) Response to mTOR inhibitor (rapamycin) ( 24009623) SAPHO syndrome ( 33816493) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Temperament ( 22832960)
Interacting Genes		21 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP	16 interacting genes: APP ARF3 ARF4 CLSTN1 CLSTN3 HUNK LRP1 LRP2 LRP8 MAGEB6 MAPK6 NECAB3 NRXN1 RELA STXBP1 USP20
Entrez ID		7804	321
HPRD ID		04002	04090
Ensembl ID		ENSG00000157193	ENSG00000034053
Uniprot IDs		Q14114	Q59G28 Q99767
PDB IDs		3A7Q 5B4X 5B4Y 7UCX
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Binding Amyloid-beta Binding Very-low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Regulation Of Multicellular Organismal Process Receptor Clustering Modulation Of Excitatory Postsynaptic Potential Neurotransmitter-gated Ion Channel Clustering Learning Or Memory Regulation Of Cell Communication Regulation Of Signaling Modulation Of Chemical Synaptic Transmission Cognition Negative Regulation Of MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Amyloid-beta Clearance Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Behavior Regulation Of Biological Quality Locomotory Behavior Negative Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Regulation Of System Process Lateral Motor Column Neuron Migration Regulation Of Synaptic Plasticity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Spinal Cord Motor Neuron Migration Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Cell Projection Organization Positive Regulation Of Amyloid Fibril Formation AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Regulation Of Neuron Projection Development Regulation Of Nervous System Process Regulation Of Membrane Potential Negative Regulation Of Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Receptor Ligand Activity Regulation Of Neurofibrillary Tangle Assembly Signal Transduction Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Regulation Of Synapse Organization Positive Regulation Of Synaptic Transmission Vesicle-mediated Transport Positive Regulation Of Nervous System Development Glutamatergic Synapse Low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Establishment Of Protein Localization Calcium Ion Binding Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Cargo Receptor Activity Regulation Of Nervous System Development Protein Transport Modulation Of Chemical Synaptic Transmission Astrocyte Activation Involved In Immune Response Chemical Synaptic Transmission Intracellular Protein Localization Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Developmental Process Golgi Apparatus Trans-synaptic Signaling NMDA Selective Glutamate Receptor Signaling Pathway Synaptic Signaling Regulation Of Synapse Assembly Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Synapse Assembly Receptor Complex Clathrin-coated Pit Endocytosis Retinoid Metabolic Process Regulation Of Lysosomal Protein Catabolic Process Diterpenoid Metabolic Process Positive Regulation Of Multicellular Organismal Process Acetylcholine Receptor Binding Amyloid-beta Binding Terpenoid Metabolic Process Regulation Of Cell Junction Assembly Neuron Projection Morphogenesis Cell Projection Morphogenesis Cellular Response To Growth Factor Stimulus Isoprenoid Metabolic Process Positive Regulation Of Catabolic Process Heparan Sulfate Proteoglycan Binding Astrocyte Activation Positive Regulation Of Cell Junction Assembly Platelet Alpha Granule Transcytosis Regulation Of Amyloid-beta Clearance Cell-cell Signaling
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