LRP8 and ITGB1BP1

Number of citations of the paper that reports this interaction (PMID 10827173)
91

Data Source:
BioGRID (two hybrid)

		LRP8	ITGB1BP1
Gene Name		low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	integrin beta 1 binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Microtubule Associated Complex Plasma Membrane Caveola Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex	Ruffle Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Reelin Receptor Activity	GDP-dissociation Inhibitor Activity Integrin Binding Protein Binding Protein Transporter Activity Protein Kinase Binding Protein Complex Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Signal Transduction Blood Coagulation Phototransduction, Visible Light Cytokine-mediated Signaling Pathway Ammon Gyrus Development Layer Formation In Cerebral Cortex Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Response To Drug Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development	Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell-matrix Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Fibroblast Migration Protein Transport Cell Migration Cell Differentiation Biomineral Tissue Development Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Integrin Activation Regulation Of Cell Adhesion Mediated By Integrin Tube Formation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cdc42 GTPase Activity Receptor Clustering Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Blood Vessel Size Myoblast Migration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Targeting To Membrane Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Integrin-mediated Signaling Pathway
Pathways		Visual phototransduction Platelet homeostasis Platelet sensitization by LDL Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594)
Protein-Protein Interactions		19 interactors: ANAPC10 APBA2 APOE APOH CLU DAB1 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP	10 interactors: APP CAMK2A EEF1A1 FAF1 FIGNL1 ITGB1 KRIT1 LRP1 LRP2 LRP8
Entrez ID		7804	9270
HPRD ID		04002	06194
Ensembl ID			ENSG00000119185
Uniprot IDs		Q14114	B4DQY5 O14713
PDB IDs		3A7Q	1K11 4DX8 4DX9 4JIF
Enriched GO Terms of Interacting Partners?		Regulation Of Beta-amyloid Clearance Membrane Depolarization Regulation Of Signaling Receptor Clustering Regulation Of Cellular Protein Metabolic Process Regulation Of Membrane Potential Positive Regulation Of Catalytic Activity Regulation Of Synaptic Transmission Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Ion Transport Regulation Of Postsynaptic Membrane Potential Regulation Of Catalytic Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Ion Transmembrane Transport Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Postsynaptic Membrane Organization Regulation Of Kinase Activity Lateral Motor Column Neuron Migration Regulation Of Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Spinal Cord Motor Neuron Migration Cell-cell Signaling Positive Regulation Of Protein Modification Process Social Behavior Learning Dendrite Development Regulation Of Ion Transmembrane Transporter Activity Behavior Positive Regulation Of Membrane Potential Regulation Of Transmembrane Transporter Activity Regulation Of Tau-protein Kinase Activity N-methyl-D-aspartate Receptor Clustering Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Epithelial Cell Migration Regulation Of Synaptic Plasticity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering	Response To Radiation Response To Abiotic Stimulus Response To Light Stimulus Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Regulation Of Apoptotic Process Detection Of Light Stimulus Regulation Of Cell Death Isoprenoid Metabolic Process Detection Of Abiotic Stimulus Regulation Of Signaling Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Stimulus Endocytosis Steroid Metabolic Process Brain Development Cellular Response To Ionizing Radiation Regulation Of Metabolic Process Head Development Visual Learning Visual Behavior Regulation Of Protein Tyrosine Kinase Activity Alcohol Metabolic Process Receptor-mediated Endocytosis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ammon Gyrus Development Beta-amyloid Clearance Associative Learning Response To External Stimulus Central Nervous System Development Response To Stimulus Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cell Death Developmental Cell Growth Negative Regulation Of Intracellular Signal Transduction Blood Vessel Morphogenesis Blood Coagulation Hemostasis Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Forebrain Development Synaptic Growth At Neuromuscular Junction Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Signaling Blood Vessel Development Cholesterol Metabolic Process
Tagcloud ?		aggregation apoe apoe4 apoer2 apolipoprotein carrier cholesterols cognition conflicting deficits emphasis feature hyperphosphorylated isoform lrp1 memory mounting neurodegeneration neurogenesis neuroinflammation neurovascular plasticity potentiation strongest summarize synaptic syndecan underexplored varepsilon4
Tagcloud (Difference) ?		aggregation apoe apoe4 apoer2 apolipoprotein carrier cholesterols cognition conflicting deficits emphasis feature hyperphosphorylated isoform lrp1 memory mounting neurodegeneration neurogenesis neuroinflammation neurovascular plasticity potentiation strongest summarize synaptic syndecan underexplored varepsilon4
Tagcloud (Intersection) ?