LRP8 and NOS1AP

Number of citations: 0 (PubMedID 10827173)
Data Source: BioGRID (two hybrid)

		LRP8	NOS1AP
Name		LDL receptor related protein 8	nitric oxide synthase 1 adaptor protein
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Microtubule Associated Complex Plasma Membrane Caveola Cell Surface Membrane Axon Dendrite Neuronal Cell Body Receptor Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Podosome Nucleus Mitochondrion Cytosol Caveola Z Disc Filopodium T-tubule Nuclear Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction Glutamatergic Synapse
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity Metal Ion Binding Calcium-dependent Protein Binding	Protein Binding Nitric-oxide Synthase Regulator Activity Signaling Adaptor Activity Nitric-oxide Synthase Binding
	Biological Process	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Chemical Synaptic Transmission Response To Xenobiotic Stimulus Cytokine-mediated Signaling Pathway Ventral Spinal Cord Development Ammon Gyrus Development Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Development Reelin-mediated Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development Regulation Of Neuron Migration	Regulation Of Heart Rate By Chemical Signal Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Cardiac Muscle Cell Action Potential Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways		Platelet sensitization by LDL Retinoid metabolism and transport	None
GWAS		Blood protein levels ( 30072576 ) Body mass index (alcohol intake interaction) ( 23192594 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cerebrospinal fluid AB1-42 levels ( 28247064 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) General risk tolerance (MTAG) ( 30643258 ) Number of sexual partners ( 30643258 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Type 2 diabetes nephropathy ( 30566433 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )	Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600 ) Body mass index (change over time) ( 25133637 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 20062061 20062063 25055868 ) Electrocardiographic traits (multivariate) ( 32602732 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Heel bone mineral density ( 30598549 ) Iris color (L* coordinate) ( 30895295 ) Lateral ventricle temporal horn volume ( 31530798 ) Long QT syndrome ( 32429735 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 27863252 ) Mosquito bite size ( 28199695 ) Obesity-related traits ( 23251661 ) QT interval ( 19305408 19305409 19587794 30679814 16648850 29874175 29213071 20031603 22726844 23166209 24952745 ) Sum of carotid plaque area ( 32469969 ) Sum of stenosis ( 32469969 ) T wave morphology restitution during exercise ( 31607149 ) T wave morphology restitution during exercise (MTAG) ( 31607149 ) T wave morphology restitution during recovery from exercise ( 31607149 ) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149 ) Word reading ( 23738518 )
Novel Interactors		1 novel interactors: KCNJ15	None recorded
Interacting Genes		21 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP	18 interacting genes: AKNAD1 APP CKM FYN HSPD1 LRP1 LRP2 LRP8 NHP2 NOS1 PLAGL2 PNP RASD1 RYBP SYN1 SYN2 SYN3 TRAF4
Entrez ID		7804	9722
HPRD ID		04002	12023
Ensembl ID		ENSG00000157193	ENSG00000198929
Uniprot IDs		Q14114	O75052
PDB IDs		3A7Q 5B4X 5B4Y 7UCX	Not available
GO Terms Enriched among Interactors		Low-density Lipoprotein Particle Receptor Binding Amyloid-beta Binding Very-low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Regulation Of Multicellular Organismal Process Receptor Clustering Modulation Of Excitatory Postsynaptic Potential Neurotransmitter-gated Ion Channel Clustering Learning Or Memory Regulation Of Cell Communication Regulation Of Signaling Modulation Of Chemical Synaptic Transmission Cognition Negative Regulation Of MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Amyloid-beta Clearance Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Behavior Regulation Of Biological Quality Locomotory Behavior Negative Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Regulation Of System Process Lateral Motor Column Neuron Migration Regulation Of Synaptic Plasticity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Spinal Cord Motor Neuron Migration Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Cell Projection Organization Positive Regulation Of Amyloid Fibril Formation AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Regulation Of Neuron Projection Development Regulation Of Nervous System Process Regulation Of Membrane Potential Negative Regulation Of Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Receptor Ligand Activity Regulation Of Neurofibrillary Tangle Assembly Signal Transduction Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Apolipoprotein Binding Synaptic Vesicle Cycle Synaptic Vesicle Clustering Low-density Lipoprotein Particle Receptor Activity Clathrin-coated Pit Synaptic Signaling Cargo Receptor Activity Schaffer Collateral - CA1 Synapse Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Astrocyte Activation Involved In Immune Response Postsynaptic Density Cellular Response To Growth Factor Stimulus Growth Factor Receptor Binding Positive Regulation Of Lysosomal Protein Catabolic Process Neurotransmitter Secretion Chemical Synaptic Transmission Response To Growth Factor Trans-synaptic Signaling Cellular Response To Amyloid-beta Positive Regulation Of Protein Catabolic Process In The Vacuole Cell-cell Signaling Regulation Of Protein Catabolic Process Signaling Response To Amyloid-beta Cell Communication Receptor Complex High-density Lipoprotein Particle Binding Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Reelin-mediated Signaling Pathway Diterpenoid Metabolic Process Cell Body Regulation Of Dendritic Spine Maintenance Calcium-dependent Protein Binding Dendrite Extrinsic Component Of Synaptic Vesicle Membrane Vesicle-mediated Transport Modulation Of Chemical Synaptic Transmission Synapse Organization Terpenoid Metabolic Process Vesicle-mediated Transport In Synapse Protein-folding Chaperone Binding Heparan Sulfate Proteoglycan Binding Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Neuron Projection Morphogenesis Astrocyte Activation Layer Formation In Cerebral Cortex Isoprenoid Metabolic Process Neurotransmitter Transport