LRP8 and RELN

Number of citations of the paper that reports this interaction (PubMedID 12899622)
0

Data Source:
HPRD (in vivo)

		LRP8	RELN
Description		LDL receptor related protein 8	reelin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Microtubule Associated Complex Plasma Membrane Caveola Cell Surface Membrane Axon Dendrite Neuronal Cell Body Receptor Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Dendrite Extracellular Matrix Neuron Projection Reelin Complex
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity Metal Ion Binding Calcium-dependent Protein Binding	Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding Receptor Ligand Activity Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Chemical Synaptic Transmission Response To Xenobiotic Stimulus Cytokine-mediated Signaling Pathway Ventral Spinal Cord Development Ammon Gyrus Development Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Development Reelin-mediated Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development Regulation Of Neuron Migration	Cell Morphogenesis Neuron Migration Proteolysis Cell Adhesion Axon Guidance Central Nervous System Development Brain Development Learning Long-term Memory Locomotory Behavior Associative Learning Glial Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Dendrite Development Cell Migration Spinal Cord Patterning Ventral Spinal Cord Development Hippocampus Development Cerebral Cortex Tangential Migration Layer Formation In Cerebral Cortex Cerebral Cortex Development Forebrain Development Positive Regulation Of TOR Signaling Protein Localization To Synapse Reelin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Differentiation Response To Pain Regulation Of Behavior Modulation Of Chemical Synaptic Transmission Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Activity Long-term Synaptic Potentiation Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Synapse Maturation Positive Regulation Of Synapse Maturation Postsynaptic Density Assembly NMDA Glutamate Receptor Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Motor Neuron Migration Lateral Motor Column Neuron Migration Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Lateral Motor Column Neuron Migration Interneuron Migration Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Neuron Migration
Pathways		Platelet sensitization by LDL Retinoid metabolism and transport	Reelin signalling pathway
Drugs
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Blood protein levels ( 30072576) Body mass index (alcohol intake interaction) ( 23192594) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 28247064) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes nephropathy ( 30566433) Urinary metabolite levels in chronic kidney disease ( 31959995)	Adult body size ( 32376654) Alzheimer's disease ( 20452100) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Intraocular pressure ( 29785010) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Metabolite levels (Pyroglutamine) ( 23934736) Morning person ( 30696823) Multiple sclerosis (age of onset) ( 19010793) Night sleep phenotypes ( 27126917) Otosclerosis ( 19230858) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Schizophrenia ( 18282107) Sjögren's syndrome ( 28076899) Sucrose liking ( 31005972) Type 2 diabetes ( 30054458 30297969) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		21 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP	9 interacting genes: DAB1 EFNB2 EFNB3 LRP8 PCDHA4 PCDHA6 RSPH1 SQSTM1 VLDLR
Entrez ID		7804	5649
HPRD ID		04002	02742
Ensembl ID		ENSG00000157193	ENSG00000189056
Uniprot IDs		Q14114	P78509
PDB IDs		3A7Q 5B4X 5B4Y 7UCX	8G21
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Binding Amyloid-beta Binding Very-low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Regulation Of Multicellular Organismal Process Receptor Clustering Modulation Of Excitatory Postsynaptic Potential Neurotransmitter-gated Ion Channel Clustering Learning Or Memory Regulation Of Cell Communication Regulation Of Signaling Modulation Of Chemical Synaptic Transmission Cognition Negative Regulation Of MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Amyloid-beta Clearance Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Behavior Regulation Of Biological Quality Locomotory Behavior Negative Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Regulation Of System Process Lateral Motor Column Neuron Migration Regulation Of Synaptic Plasticity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Spinal Cord Motor Neuron Migration Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Cell Projection Organization Positive Regulation Of Amyloid Fibril Formation AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Regulation Of Neuron Projection Development Regulation Of Nervous System Process Regulation Of Membrane Potential Negative Regulation Of Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Receptor Ligand Activity Regulation Of Neurofibrillary Tangle Assembly Signal Transduction Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Ventral Spinal Cord Development Reelin-mediated Signaling Pathway Nervous System Development Glutamatergic Synapse Reelin Receptor Activity Very-low-density Lipoprotein Particle Receptor Activity Regulation Of Neuron Projection Development System Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Developmental Process Regulation Of Cell Projection Organization Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Dendrite Development Apolipoprotein Binding Layer Formation In Cerebral Cortex Negative Regulation Of Neuron Projection Development Cell Adhesion Cargo Receptor Activity Ephrin Receptor Binding Adult Walking Behavior Negative Regulation Of Cell Projection Organization Walking Behavior Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Projection Organization T Cell Costimulation Calcium Ion Binding Dendrite Morphogenesis Ephrin Receptor Signaling Pathway Negative Regulation Of Axonogenesis Cell Projection Morphogenesis Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Neuron Projection Morphogenesis Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Ammon Gyrus Development Cell Surface Receptor Signaling Pathway Regulation Of Synapse Organization Hippocampus Development Cerebellum Structural Organization Adult Locomotory Behavior Positive Regulation Of Aorta Morphogenesis Virus Receptor Activity Calcium-dependent Protein Binding Brown Fat Cell Proliferation Amphisome Regulation Of Neurogenesis Cell Adhesion Molecule Binding Regulation Of Anatomical Structure Morphogenesis Regulation Of Dendrite Development Lateral Motor Column Neuron Migration Radial Glia Guided Migration Of Purkinje Cell
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