LRP8 and APOH

Number of citations of the paper that reports this interaction (PubMedID 12807892)
0

Data Source:
HPRD (in vivo)

		LRP8	APOH
Description		LDL receptor related protein 8	apolipoprotein H
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Microtubule Associated Complex Plasma Membrane Caveola Cell Surface Membrane Axon Dendrite Neuronal Cell Body Receptor Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Extracellular Space Cell Surface Platelet Dense Granule Lumen Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity Metal Ion Binding Calcium-dependent Protein Binding	Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Lipase Binding Identical Protein Binding Lipoprotein Lipase Activator Activity
	Biological Process	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Chemical Synaptic Transmission Response To Xenobiotic Stimulus Cytokine-mediated Signaling Pathway Ventral Spinal Cord Development Ammon Gyrus Development Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Development Reelin-mediated Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development Regulation Of Neuron Migration	Negative Regulation Of Endothelial Cell Proliferation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Myeloid Cell Apoptotic Process Triglyceride Transport Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Fibrinolysis Negative Regulation Of Fibrinolysis Positive Regulation Of Triglyceride Metabolic Process
Pathways		Platelet sensitization by LDL Retinoid metabolism and transport	Platelet degranulation
Drugs			LJP 1082 Copper
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index (alcohol intake interaction) ( 23192594) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 28247064) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes nephropathy ( 30566433) Urinary metabolite levels in chronic kidney disease ( 31959995)	β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Activated partial thromboplastin time ( 29403010) Alanine aminotransferase levels ( 34315874) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Brain morphology (MOSTest) ( 32665545) Cardiometabolic and hematological traits ( 27668658) Coronary artery disease ( 29212778) Creatine kinase levels ( 29403010) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alanine transaminase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Presence of antiphospholipid antibodies ( 27098658) Systolic blood pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531)
Interacting Genes		21 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP	14 interacting genes: AKT1 ANXA2 CDC42 CLEC4G F10 F12 GEM GRB2 LPA LRP2 LRP8 OGT PLG RBBP6
Entrez ID		7804	350
HPRD ID		04002	00728
Ensembl ID		ENSG00000157193	ENSG00000091583
Uniprot IDs		Q14114	A0A384NKM6 P02749
PDB IDs		3A7Q 5B4X 5B4Y 7UCX	1C1Z 1G4F 1G4G 1QUB 2KRI 3OP8 4JHS 6V06 6V08 6V09 6XSD 6XST 7JIK 7KG4
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Binding Amyloid-beta Binding Very-low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Regulation Of Multicellular Organismal Process Receptor Clustering Modulation Of Excitatory Postsynaptic Potential Neurotransmitter-gated Ion Channel Clustering Learning Or Memory Regulation Of Cell Communication Regulation Of Signaling Modulation Of Chemical Synaptic Transmission Cognition Negative Regulation Of MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Amyloid-beta Clearance Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Behavior Regulation Of Biological Quality Locomotory Behavior Negative Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Regulation Of System Process Lateral Motor Column Neuron Migration Regulation Of Synaptic Plasticity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Spinal Cord Motor Neuron Migration Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Cell Projection Organization Positive Regulation Of Amyloid Fibril Formation AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Regulation Of Neuron Projection Development Regulation Of Nervous System Process Regulation Of Membrane Potential Negative Regulation Of Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Receptor Ligand Activity Regulation Of Neurofibrillary Tangle Assembly Signal Transduction Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Fibrinolysis Apolipoprotein Binding Proteolysis Serine-type Peptidase Activity Positive Regulation Of Fibrinolysis Plasma Membrane Serine-type Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Proteolysis Positive Regulation Of Multicellular Organismal Process Regulation Of Protein Maturation Positive Regulation Of Plasminogen Activation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Positive Regulation Of TOR Signaling Glutamatergic Synapse Regulation Of Body Fluid Levels Low-density Lipoprotein Particle Receptor Activity Regulation Of Cell Migration Regulation Of Synapse Organization Regulation Of Plasminogen Activation Calcium Ion Binding Coagulation Blood Coagulation Regulation Of Fibrinolysis Regulation Of Cell Motility Hemostasis Protein Maturation Regulation Of Locomotion Regulation Of Multicellular Organismal Process Labyrinthine Layer Blood Vessel Development External Side Of Plasma Membrane Regulation Of Proteolysis Regulation Of Postsynapse Organization Regulation Of Protein Catabolic Process Regulation Of Wound Healing Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Spindle Midzone Positive Regulation Of Blood Coagulation Cargo Receptor Activity Blood Vessel Development Regulation Of TOR Signaling Positive Regulation Of Coagulation Embryonic Organ Development Placenta Blood Vessel Development Regulation Of Cell Adhesion
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