WIPF1 and FASTK

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		WIPF1	FASTK
Description		WAS/WASL interacting protein family member 1	Fas activated serine/threonine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Actin Cytoskeleton Cytoplasmic Vesicle Cell Projection	Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule
	Molecular Function	Actin Binding Protein Binding Profilin Binding Cytoskeletal Anchor Activity SH3 Domain Binding Protein Folding Chaperone	Nucleotide Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Fas-activated Serine/threonine Kinase Activity Protein Serine Kinase Activity
	Biological Process	Protein Folding Actin Polymerization Or Depolymerization Actin Filament-based Process Actin Filament-based Movement Response To Other Organism Protein-containing Complex Assembly	Mitochondrial RNA Processing Protein Phosphorylation Apoptotic Process Regulation Of RNA Splicing Regulation Of Mitochondrial MRNA Stability Apoptotic Signaling Pathway
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Systolic blood pressure ( 27841878) Urate levels (BMI interaction) ( 25811787)	Eyebrow thickness ( 26926045)
Interacting Genes		26 interacting genes: ABI2 ACTC1 ACTG1 ALAS1 APBB1 CACNG2 CDC42 CEBPA CRKL CTTN FASTK GRB2 HCK HOMER3 ITSN2 NCK1 PRKCQ PRPF40A RER1 SEC24C SH3RF1 WAS WASL WBP4 WWP2 ZAP70	9 interacting genes: CALCOCO2 CHERP ESRRG MDFI PRPF31 RBPMS TIA1 TOP3B WIPF1
Entrez ID		7456	10922
HPRD ID		03835	07368
Ensembl ID		ENSG00000115935	ENSG00000164896
Uniprot IDs		A0A140VJZ9 E9PB87 O43516 Q2YDC4	A0A090N8I0 A0A090N8Z7 Q14296
PDB IDs		2A41 9EZN 9EZO 9EZP
Enriched GO Terms of Interacting Partners?		Actin Filament Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cell Motility Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Cell-cell Junction Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Proline-rich Region Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Migration Cytosol Regulation Of Cell Projection Organization Positive Regulation Of Protein Polymerization Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Actin Cytoskeleton Organization Dendritic Spine Organization Cell Projection Organization Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Vesicle Membrane Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Projection Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Polymerization Postsynapse Organization Neuron Projection Morphogenesis Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Small GTPase-mediated Signal Transduction Cell Junction Organization Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway	RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Binding RNA Topoisomerase Activity Ribonucleoprotein Complex Localization Cytoplasmic Stress Granule DNA Topoisomerase III-beta-TDRD3 Complex U4atac SnRNP AF-2 Domain Binding Regulation Of MRNA Processing MRNA 3'-UTR Binding Regulation Of MRNA Splicing, Via Spliceosome DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity MRNA CDS Binding SnRNP Binding U4atac SnRNA Binding Nucleic Acid Binding SnoRNA Localization
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