WIPF1 and CACNG2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WIPF1	CACNG2
Description		WAS/WASL interacting protein family member 1	calcium voltage-gated channel auxiliary subunit gamma 2
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Actin Cytoskeleton Cytoplasmic Vesicle Cell Projection	Plasma Membrane Voltage-gated Calcium Channel Complex Cell Surface Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Monoatomic Ion Channel Complex Somatodendritic Compartment Neuron Projection Organelle Cerebellar Mossy Fiber Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Profilin Binding Cytoskeletal Anchor Activity SH3 Domain Binding Protein Folding Chaperone	Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Channel Regulator Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Protein Folding Actin Polymerization Or Depolymerization Actin Filament-based Process Actin Filament-based Movement Response To Other Organism Protein-containing Complex Assembly	Protein Targeting To Membrane Monoatomic Ion Transport Calcium Ion Transport Neuromuscular Junction Development Transmission Of Nerve Impulse Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Response To Calcium Ion Membrane Depolarization Positive Regulation Of Synaptic Transmission, Glutamatergic Membrane Hyperpolarization Eye Blink Reflex Calcium Ion Transmembrane Transport Postsynaptic Neurotransmitter Receptor Diffusion Trapping Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Localization To Basolateral Plasma Membrane Regulation Of AMPA Receptor Activity
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Presynaptic depolarization and calcium channel opening Trafficking of AMPA receptors LGI-ADAM interactions
Drugs			Ergocalciferol Enflurane Spironolactone Nicardipine Verapamil Ethanol Efonidipine Butamben Bioallethrin
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Systolic blood pressure ( 27841878) Urate levels (BMI interaction) ( 25811787)	Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Daytime nap ( 33568662)
Interacting Genes		26 interacting genes: ABI2 ACTC1 ACTG1 ALAS1 APBB1 CACNG2 CDC42 CEBPA CRKL CTTN FASTK GRB2 HCK HOMER3 ITSN2 NCK1 PRKCQ PRPF40A RER1 SEC24C SH3RF1 WAS WASL WBP4 WWP2 ZAP70	11 interacting genes: APP DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA4 PATJ PRKACA SRPK2 WIPF1
Entrez ID		7456	10369
HPRD ID		03835	04220
Ensembl ID		ENSG00000115935	ENSG00000166862
Uniprot IDs		A0A140VJZ9 E9PB87 O43516 Q2YDC4	Q9Y698
PDB IDs		2A41 9EZN 9EZO 9EZP	6DLZ 6DM0 6DM1 6O9G 6TNO
Enriched GO Terms of Interacting Partners?		Actin Filament Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cell Motility Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Cell-cell Junction Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Proline-rich Region Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Migration Cytosol Regulation Of Cell Projection Organization Positive Regulation Of Protein Polymerization Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Actin Cytoskeleton Organization Dendritic Spine Organization Cell Projection Organization Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Vesicle Membrane Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Projection Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Polymerization Postsynapse Organization Neuron Projection Morphogenesis Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Small GTPase-mediated Signal Transduction Cell Junction Organization Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway	Neuromuscular Junction Postsynaptic Density Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Cell Communication AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Binding Ligand-gated Ion Channel Signaling Pathway Cell-cell Signaling Receptor Localization To Synapse Receptor Clustering Glutamate Receptor Signaling Pathway Neuron Projection Signaling Establishment Or Maintenance Of Cell Polarity Protein Localization To Synapse Synaptic Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Protein Kinase Binding Protein Localization To Cell Junction Kinase Binding Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Cell Projection Modulation Of Excitatory Postsynaptic Potential Regulation Of Membrane Potential Adherens Junction NMDA Selective Glutamate Receptor Signaling Pathway AMPA Glutamate Receptor Activity Modulation Of Chemical Synaptic Transmission Synapse Postsynapse Presynapse Neuron Spine Endocytic Vesicle Membrane GMP Kinase Activity Regulation Of System Process Postsynaptic Density Glutamatergic Synapse Cellular Component Assembly Glutamate-gated Receptor Activity GDP Metabolic Process Regulation Of Monoatomic Ion Transmembrane Transport Juxtaparanode Region Of Axon Acetylcholine Receptor Binding Regulation Of Biological Quality
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