WIPF1 and RER1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WIPF1	RER1
Description		WAS/WASL interacting protein family member 1	retention in endoplasmic reticulum sorting receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Actin Cytoskeleton Cytoplasmic Vesicle Cell Projection	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Cell Surface Membrane
	Molecular Function	Actin Binding Protein Binding Profilin Binding Cytoskeletal Anchor Activity SH3 Domain Binding Protein Folding Chaperone	Protein Binding Acetylcholine Receptor Binding
	Biological Process	Protein Folding Actin Polymerization Or Depolymerization Actin Filament-based Process Actin Filament-based Movement Response To Other Organism Protein-containing Complex Assembly	Protein Retention In ER Lumen Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Neuromuscular Junction Development Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Systolic blood pressure ( 27841878) Urate levels (BMI interaction) ( 25811787)	Body mass index ( 26426971) Metabolite levels ( 23823483) Serum alkaline phosphatase levels ( 33547301) Vitamin C levels ( 33203707)
Interacting Genes		26 interacting genes: ABI2 ACTC1 ACTG1 ALAS1 APBB1 CACNG2 CDC42 CEBPA CRKL CTTN FASTK GRB2 HCK HOMER3 ITSN2 NCK1 PRKCQ PRPF40A RER1 SEC24C SH3RF1 WAS WASL WBP4 WWP2 ZAP70	6 interacting genes: HAP1 IMMT SCAND1 SH3GL3 SYT16 WIPF1
Entrez ID		7456	11079
HPRD ID		03835	17967
Ensembl ID		ENSG00000115935	ENSG00000157916
Uniprot IDs		A0A140VJZ9 E9PB87 O43516 Q2YDC4	O15258 Q5T094
PDB IDs		2A41 9EZN 9EZO 9EZP
Enriched GO Terms of Interacting Partners?		Actin Filament Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cell Motility Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Cell-cell Junction Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Proline-rich Region Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Migration Cytosol Regulation Of Cell Projection Organization Positive Regulation Of Protein Polymerization Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Actin Cytoskeleton Organization Dendritic Spine Organization Cell Projection Organization Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Vesicle Membrane Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Projection Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Polymerization Postsynapse Organization Neuron Projection Morphogenesis Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Small GTPase-mediated Signal Transduction Cell Junction Organization Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway
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