WIPF1 and ACTG1

Number of citations of the paper that reports this interaction (PMID 11331876)
60

Data Source:
BioGRID (pull down)

		WIPF1	ACTG1
Gene Name		WAS/WASL interacting protein family, member 1	actin gamma 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytosol Actin Filament Actin Cytoskeleton Cytoplasmic Membrane-bounded Vesicle	Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Membrane Myofibril Filamentous Actin Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Actin Binding Protein Binding Profilin Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Protein Complex Assembly Actin Polymerization Or Depolymerization Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Response To Other Organism	Retina Homeostasis Movement Of Cell Or Subcellular Component Axon Guidance Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Sarcomere Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Membrane Organization Platelet Aggregation
Pathways		Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Cell junction organization Formation of annular gap junctions Gap junction trafficking Signaling by VEGF Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: ABI2 ACTC1 ACTG1 ALAS1 APBB1 CDC42 CRKL CTTN FASTK GRB2 HCK HOMER3 ITSN2 NCK1 PRKCQ PRPF40A SEC24C WAS WASL WBP4 WWP2 ZAP70	60 interactors: ABLIM1 ACTB ANXA5 APOE ATF7IP BCAP31 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK LGALS13 LIG4 LSP1 MAP1A MAPK6 MYO1A MYOC NDRG1 NR3C2 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WDYHV1 WIPF1
Entrez ID		7456	71
HPRD ID		03835	00017
Ensembl ID		ENSG00000115935	ENSG00000184009
Uniprot IDs		O43516 Q2YDC4	P63261
PDB IDs		2A41
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Immune Response Phagocytosis Endocytosis Actin Filament Organization Regulation Of Cytoskeleton Organization Innate Immune Response Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Cell Migration Actin Cytoskeleton Organization Positive Regulation Of Actin Nucleation Regulation Of Immune Response Axon Guidance Cell Motility Positive Regulation Of Immune System Process Positive Regulation Of Organelle Organization Actin Filament-based Process Regulation Of Actin Filament-based Process Neuron Projection Morphogenesis Neuron Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle-mediated Transport Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Organization Neuron Differentiation Axonogenesis Cell Projection Organization Cell Projection Morphogenesis Axon Development Cell Part Morphogenesis Actin Polymerization Or Depolymerization Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Organelle Organization Immune System Process Immune Response	Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Organelle Organization Organelle Organization Regulation Of Cellular Component Size Chemotaxis Cell Projection Organization Neurogenesis Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Complex Assembly Neuron Projection Development Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Axon Guidance Generation Of Neurons Actin Filament Severing Positive Regulation Of Cellular Component Biogenesis Locomotion Regulation Of Protein Depolymerization Cell Development Response To External Stimulus Neuron Development Nervous System Development Axon Development Regulation Of Protein Complex Disassembly Regulation Of Cell Projection Organization Actin Filament Depolymerization Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Signal Transduction
Tagcloud ?			alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?			alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?