YWHAZ and VIM

Number of citations of the paper that reports this interaction (PMID 10887173)
30

Data Source:
HPRD (in vivo)

		YWHAZ	VIM
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta	vimentin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Focal Adhesion Postsynaptic Density Cytoplasmic Vesicle Membrane Cell Leading Edge Melanosome Mast Cell Granule Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Peroxisome Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Focal Adhesion Cell Leading Edge Neuron Projection Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Domain Specific Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding	Glycoprotein Binding Double-stranded RNA Binding Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding Protein C-terminus Binding Identical Protein Binding Scaffold Protein Binding
	Biological Process	Histamine Secretion By Mast Cell Protein Targeting To Mitochondrion Apoptotic Process Signal Transduction Blood Coagulation Gene Expression Platelet Activation Response To Drug Negative Regulation Of Apoptotic Process Establishment Of Golgi Localization Membrane Organization Golgi Reassembly Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Movement Of Cell Or Subcellular Component Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Astrocyte Development Viral Process Muscle Filament Sliding Intermediate Filament Organization Bergmann Glial Cell Differentiation SMAD Protein Signal Transduction Lens Fiber Cell Development
Pathways		Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Signaling by Wnt deactivation of the beta-catenin transactivating complex Rap1 signalling RNF mutants show enhanced WNT signaling and proliferation Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Intrinsic Pathway for Apoptosis Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Cytokine Signaling in Immune system Activation of BAD and translocation to mitochondria Signaling by Interleukins TCF dependent signaling in response to WNT KSRP destabilizes mRNA GP1b-IX-V activation signalling Signaling by WNT in cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System	Apoptotic cleavage of cellular proteins Striated Muscle Contraction Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		191 interactors: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARAF ARHGEF2 ATP5A1 ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CFL1 CGNL1 CLIC4 CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EPB41L1 EPB41L2 EPB41L3 EXO1 FAM13B FAM53C FHOD1 FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 HDAC4 HDAC9 HIST1H3A HIVEP2 HMGN1 HSPA1A HSPA1B IGF1R IL9R ING1 INPP5A IRS1 IRS2 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIAA1377 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LCP2 LIMK1 LRMP LYST MADD MAP2K5 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MYH9 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PDC PFKFB2 PIAS1 PPP1CC PPP1R14A PRDX2 PRKCA PRKCD PRKCI PRKCZ PRKD1 PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RFWD2 RGS3 RIN1 RMDN3 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNX24 SORBS2 SQSTM1 SSFA2 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UBE3A UCHL5 UCP2 UCP3 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YWHAE ZAK ZNF839	140 interactors: ABLIM1 AKT1 ALS2CR11 ANKRD35 ANXA7 APIP APLP1 APP ARMCX2 ATN1 BFSP1 BHLHE40 BRD1 CAMK2D CAPN1 CASP3 CASP6 CASP7 CASP8 CASP9 CDH5 CDK1 CDKN1A CHD3 COPS6 CRCT1 CREB1 CRMP1 CWF19L2 DCTN1 DEFB1 DGCR14 DIS3L2 DNM1L DPPA4 DSP DYNLL1 EIF3I FABP4 FAM107A FAM118B FUBP1 GADD45A GFAP GOPC GRB2 GSK3B HABP4 HAP1 HMG20B HTRA2 ING5 ITGB4 IVNS1ABP KARS KAT7 KIAA0408 KIAA1377 KIF15 KRT20 LOR LRIF1 MAFG MAN2A2 MEN1 MICAL1 MRPL44 NEFL NFATC2 NIF3L1 NME2 NOC4L NR1H2 NUP85 OSBP2 PAK2 PDLIM1 PIAS4 PKD1 PKN1 PKP1 PLA2G2A PLA2G4A PLEC PNMA5 POLR1C PPHLN1 PPL PRKACA PRPH PSMA1 PSMD7 PSME1 PUF60 RAB8B RABAC1 RAD51 RBM48 RIBC2 ROCK1 RPA1 SDCCAG3 SERBP1 SETDB1 SH3GL1 SH3GL3 SH3YL1 SIRT6 SLC25A6 SLC27A6 SMAD3 SRRT STX1A SUMO2 SUMO3 SYN1 TAB2 TCHP TNFRSF14 TNNT1 TRIM28 TRIM29 TRIOBP TSC22D1 TTR TUBGCP4 TXLNB TXN TXN2 UPP1 UPP2 UROD UTP14A WBP11 XRCC4 YAE1D1 YWHAE YWHAZ ZHX1 ZNF384
Entrez ID		7534	7431
HPRD ID		03183	01899
Ensembl ID		ENSG00000164924	ENSG00000026025
Uniprot IDs		D0PNI1 P63104	P08670
PDB IDs		1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL	1GK4 1GK6 1GK7 3G1E 3KLT 3S4R 3SSU 3SWK 3TRT 3UF1
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Cell Communication Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Signal Transduction Regulation Of Kinase Activity Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Protein Kinase Activity Response To Stress Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Signal Transduction Protein Phosphorylation Neurotrophin Signaling Pathway Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Response To Organic Substance Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Death Regulation Of MAPK Cascade Apoptotic Process Cell Death Death Programmed Cell Death Positive Regulation Of Protein Modification Process Phosphate-containing Compound Metabolic Process Regulation Of Apoptotic Process Innate Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization	Programmed Cell Death Apoptotic Process Cell Death Death Execution Phase Of Apoptosis Regulation Of Cell Death Response To Abiotic Stimulus Regulation Of Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Positive Regulation Of Proteolysis Regulation Of Cellular Localization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Cellular Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Death Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Organelle Organization Cell Cycle Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Gene Expression Immune System Process Regulation Of Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Positive Regulation Of Signal Transduction Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Programmed Cell Death Cellular Process Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Viral Process Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		actb arfgap2 arl1 bestkeeper bmi1 casc3 cynomolgus ddx3x gapdh genorm lists monkey morf4 mrfap1 normalization normfinder ormdl1 prerequisite reference ribosylation rps19 rsl24d1 sar1a traditionally transcriptome usp22 vitally zc3h11a zranb2	10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded f13a1 flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vws woude z
Tagcloud (Difference) ?		actb arfgap2 arl1 bestkeeper bmi1 casc3 cynomolgus ddx3x gapdh genorm lists monkey morf4 mrfap1 normalization normfinder ormdl1 prerequisite reference ribosylation rps19 rsl24d1 sar1a traditionally transcriptome usp22 vitally zc3h11a zranb2	10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded f13a1 flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vws woude z
Tagcloud (Intersection) ?