YWHAZ and BRAF

Number of citations: 0 (PubMedID 8668348)
Data Source: HPRD (two hybrid)

		YWHAZ	BRAF
Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	B-Raf proto-oncogene, serine/threonine kinase
Structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Vesicle Melanosome Extracellular Exosome Blood Microparticle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cilium Membrane Centriolar Satellite Ciliary Basal Body Neuron Projection Cell Body Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Transmembrane Transporter Binding Cadherin Binding Phosphoserine Residue Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Respiratory System Process Protein Phosphorylation Protein Targeting Lysosome Organization Signal Transduction Synaptic Target Recognition Intracellular Protein Localization Lung Development Regulation Of Protein Stability Cellular Response To Nutrient Levels Tube Formation TORC1 Signaling Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Innate Immune Response Establishment Of Golgi Localization ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Regulation Of Synapse Maturation Golgi Reassembly Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of TORC1 Signaling Regulation Of Lysosome Organization	MAPK Cascade Myeloid Progenitor Cell Differentiation Protein Phosphorylation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Visual Learning Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Fibroblast Migration Positive Regulation Of D-glucose Transmembrane Transport Synaptic Vesicle Exocytosis Cell Differentiation Thyroid Gland Development T Cell Differentiation In Thymus Positive Regulation Of Peptidyl-serine Phosphorylation Substrate Adhesion-dependent Cell Spreading Somatic Stem Cell Population Maintenance Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Stress Fiber Assembly CD4-positive, Alpha-beta T Cell Differentiation Positive T Cell Selection CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Neuron Apoptotic Process Regulation Of T Cell Differentiation Alpha-beta T Cell Differentiation Thymus Development Regulation Of Axon Regeneration Positive Regulation Of Axon Regeneration Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Long-term Synaptic Potentiation Head Morphogenesis Face Development ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Cellular Response To Xenobiotic Stimulus Endothelial Cell Apoptotic Process Establishment Of Protein Localization To Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Spry regulation of FGF signaling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signalling to p38 via RIT and RIN RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs		Phenethyl Isothiocyanate	Sorafenib XL281 RAF-265 PLX-4720 N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime Vemurafenib Regorafenib Dabrafenib Encorafenib Fostamatinib Ripretinib
Diseases		None	Malignant melanoma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Thyroid cancer
GWAS		Adventurousness ( 30643258 ) Attention deficit hyperactivity disorder and conduct disorder ( 18951430 ) Body mass index ( 25673413 ) Chronotype ( 30696823 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) General risk tolerance (MTAG) ( 30643258 ) High light scatter reticulocyte count ( 32888494 ) Interleukin-10 levels ( 22205395 )	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Bipolar disorder ( 31043756 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872 ) Cerebrospinal T-tau levels ( 26252872 ) Longevity ( 33657282 ) Mild influenza (H1N1) infection ( 26379185 ) Response to Vitamin E supplementation ( 22437554 ) Type 2 diabetes ( 28869590 32499647 )
Interacting Genes		204 interacting genes: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARHGEF2 ATP5F1A ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CEP126 CEP131 CFL1 CGNL1 CLIC4 COP1 CPAP CRBN CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EP300 EPB41L1 EPB41L3 ERBB2 ERBB3 EXO1 FAM13B FHOD1 FNDC3B FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 GSK3B HDAC4 HDAC9 HMGN1 HSP90AA1 HSPA1A HSPA1B HSPB1 HSPB6 IGF1R IL9R ING1 INPP5A IRAG2 IRS1 IRS2 KANK1 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LATS2 LCP2 LIMK1 LNX1 MADD MAP2K5 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MTNR1A MYH9 NCAM2 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PCNT PDC PFKFB2 PIAS1 PPP1CC PPP1R14A PPP1R3D PRKACA PRKAR1A PRKCA PRKCD PRKCI PRKCZ PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RGS3 RIN1 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNAPIN SNX24 SORBS2 SQSTM1 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBC1D7 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UCHL5 UCP2 UCP3 USP8 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YAP1 YWHAE ZNF839	44 interacting genes: AKT1 AURKA BAD CCDC88A CTSV FBP1 HRAS HSD17B3 ITCH LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAPK1 MAPK3 MRAS NANOG OIP5 PAK2 PEBP1 PPP2CA PPP2R2A PRKACA PRKCE RAF1 RAP1A RAP1GAP RASSF1 RHEB SFN SGK1 SPOP SPRY2 STK11 TERF1 TERT YWHAB YWHAG YWHAH YWHAQ YWHAZ ZNF189 ZNF510
Entrez ID		7534	673
HPRD ID		03183	01264
Ensembl ID		ENSG00000164924	ENSG00000157764
Uniprot IDs		D0PNI1 P63104	A0A2R8Y8E0 A0A2U3TZI2 H7C560 P15056
PDB IDs		1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL 4N7G 4N7Y 4N84 4WRQ 4ZDR 5D2D 5D3F 5EWZ 5EXA 5J31 5JM4 5M35 5M36 5M37 5NAS 5ULO 5WXN 5XY9 6EF5 6EJL 6EWW 6F08 6F09 6FN9 6FNA 6FNB 6FNC 6Q0K 6RLZ 6U2H 6XAG 6YMO 6YO8 6YOS 6ZFD 6ZFG 7D8H 7D8P 7D9V 7MFD 7MFE 7MFF 7Q16 7ZIT 8A9G 8AH2 8QDV 8WE2 8WF6 9FUM 9FVL	1UWH 1UWJ 2FB8 2L05 3C4C 3D4Q 3IDP 3II5 3NY5 3OG7 3PPJ 3PPK 3PRF 3PRI 3PSB 3PSD 3Q4C 3Q96 3SKC 3TV4 3TV6 4CQE 4DBN 4E26 4E4X 4EHE 4EHG 4FC0 4FK3 4G9C 4G9R 4H58 4JVG 4KSP 4KSQ 4MBJ 4MNE 4MNF 4PP7 4R5Y 4RZV 4RZW 4WO5 4XV1 4XV2 4XV3 4XV9 4YHT 5C9C 5CSW 5CSX 5CT7 5FD2 5HI2 5HID 5HIE 5ITA 5J17 5J18 5J2R 5JRQ 5JSM 5JT2 5VAL 5VAM 5VR3 5VYK 6B8U 6CAD 6N0P 6N0Q 6NSQ 6NYB 6P3D 6P7G 6PP9 6Q0J 6Q0K 6Q0T 6U2G 6U2H 6UAN 6UUO 6V2U 6V2W 6V34 6XAG 6XFP 6XLO 7K0V 7M0T 7M0U 7M0V 7M0W 7M0X 7M0Y 7M0Z 7MFD 7MFE 7MFF 7P3V 7SHV 7ZR0 7ZR5 7ZR6 8C7X 8C7Y 8DGS 8DGT 8F7O 8F7P 8QQG 9AXX 9AXY 9BFB 9F35
GO Terms Enriched among Interactors		Cytoplasm Intracellular Signal Transduction Protein Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Cytosol Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Signal Transduction ATP Binding Intracellular Signaling Cassette Regulation Of Protein Modification Process Protein Modification Process Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Nucleotide Binding Regulation Of Protein Localization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process Transferase Activity Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Phosphorus Metabolic Process Regulation Of Multicellular Organismal Process Protein Kinase Binding Phosphate-containing Compound Metabolic Process Positive Regulation Of Protein Localization Protein Metabolic Process Regulation Of Cell Cycle Cell Surface Receptor Signaling Pathway Response To Stress Protein-containing Complex MAPK Cascade Positive Regulation Of Cellular Component Organization	Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Intracellular Signaling Cassette Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Protein Modification Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Primary Metabolic Process Protein Kinase Activity Regulation Of Cellular Component Organization Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Macromolecule Metabolic Process Regulation Of MAPK Cascade Schwann Cell Development Regulation Of Metabolic Process Phosphorylation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway MAPK Cascade Kinase Activity Regulation Of Golgi Inheritance Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Catalytic Activity Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Regulation Of Cellular Localization Regulation Of Protein Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Cellular Component Organization Cytosol Trachea Formation Positive Regulation Of Intracellular Signal Transduction TOR Signaling Positive Regulation Of Protein Modification Process