YWHAZ and TUBB

Number of citations of the paper that reports this interaction (PubMedID 15324660)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		YWHAZ	TUBB
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	tubulin beta class I
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Vesicle Melanosome Extracellular Exosome Blood Microparticle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Intercellular Bridge Extracellular Exosome Mitotic Spindle
	Molecular Function	RNA Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Transmembrane Transporter Binding Cadherin Binding Phosphoserine Residue Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity	Nucleotide Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Respiratory System Process Protein Phosphorylation Protein Targeting Lysosome Organization Signal Transduction Synaptic Target Recognition Intracellular Protein Localization Lung Development Regulation Of Protein Stability Cellular Response To Nutrient Levels Tube Formation TORC1 Signaling Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Innate Immune Response Establishment Of Golgi Localization ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Regulation Of Synapse Maturation Golgi Reassembly Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of TORC1 Signaling Regulation Of Lysosome Organization	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Regulation Of Synapse Organization Spindle Assembly Cell Division Odontoblast Differentiation
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 Potential therapeutics for SARS
Drugs		Phenethyl Isothiocyanate	Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Tirbanibulin Copper Artenimol Vinflunine Depatuxizumab mafodotin Milataxel Colchiceine
Diseases
GWAS		Adventurousness ( 30643258) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Body mass index ( 25673413) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) General risk tolerance (MTAG) ( 30643258) High light scatter reticulocyte count ( 32888494) Interleukin-10 levels ( 22205395)	Autism spectrum disorder or schizophrenia ( 28540026) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		204 interacting genes: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARHGEF2 ATP5F1A ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CEP126 CEP131 CFL1 CGNL1 CLIC4 COP1 CPAP CRBN CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EP300 EPB41L1 EPB41L3 ERBB2 ERBB3 EXO1 FAM13B FHOD1 FNDC3B FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 GSK3B HDAC4 HDAC9 HMGN1 HSP90AA1 HSPA1A HSPA1B HSPB1 HSPB6 IGF1R IL9R ING1 INPP5A IRAG2 IRS1 IRS2 KANK1 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LATS2 LCP2 LIMK1 LNX1 MADD MAP2K5 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MTNR1A MYH9 NCAM2 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PCNT PDC PFKFB2 PIAS1 PPP1CC PPP1R14A PPP1R3D PRKACA PRKAR1A PRKCA PRKCD PRKCI PRKCZ PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RGS3 RIN1 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNAPIN SNX24 SORBS2 SQSTM1 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBC1D7 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UCHL5 UCP2 UCP3 USP8 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YAP1 YWHAE ZNF839	84 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BCL2L13 BMPR2 BRCA1 CDK1 CDKN2A CLIP1 CMTM5 CNN1 CREBBP CRIPT DISC1 DPYSL2 DUX4 DYNLL1 EML4 ESR1 FXR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LINC01554 LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 OGT PFDN4 PLK1 PRKN PRMT1 PTEN RAB8B RACK1 RASSF1 RSPH1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TBKBP1 TGM2 TINF2 TPPP TTBK1 TTK TUBA1A UBE3A USP25 VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19
Entrez ID		7534	203068
HPRD ID		03183	01852
Ensembl ID		ENSG00000164924	ENSG00000196230
Uniprot IDs		D0PNI1 P63104	B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16
PDB IDs		1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL 4N7G 4N7Y 4N84 4WRQ 4ZDR 5D2D 5D3F 5EWZ 5EXA 5J31 5JM4 5M35 5M36 5M37 5NAS 5ULO 5WXN 5XY9 6EF5 6EJL 6EWW 6F08 6F09 6FN9 6FNA 6FNB 6FNC 6Q0K 6RLZ 6U2H 6XAG 6YMO 6YO8 6YOS 6ZFD 6ZFG 7D8H 7D8P 7D9V 7MFD 7MFE 7MFF 7Q16 7ZIT 8A9G 8AH2 8QDV 8WE2 8WF6 9FUM 9FVL	3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVE 6QVJ 7TRG 7TTN 7TTT 7TUB 7X0S 8BPO 8T42 8U3Z 8V2J 9BP6
Enriched GO Terms of Interacting Partners?		Cytoplasm Intracellular Signal Transduction Protein Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Cytosol Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Signal Transduction ATP Binding Intracellular Signaling Cassette Regulation Of Protein Modification Process Protein Modification Process Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Nucleotide Binding Regulation Of Protein Localization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process Transferase Activity Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Phosphorus Metabolic Process Regulation Of Multicellular Organismal Process Protein Kinase Binding Phosphate-containing Compound Metabolic Process Positive Regulation Of Protein Localization Protein Metabolic Process Regulation Of Cell Cycle Cell Surface Receptor Signaling Pathway Response To Stress Protein-containing Complex MAPK Cascade Positive Regulation Of Cellular Component Organization	Microtubule-based Process Microtubule Cytoskeleton Organization Organelle Organization Microtubule Binding Microtubule Regulation Of Cellular Component Organization Cytoskeleton Organization Microtubule Polymerization Tubulin Binding Identical Protein Binding Microtubule Cytoskeleton Microtubule Associated Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Polymerization Or Depolymerization Cytoskeleton Cytosol Neuron Projection Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-tubulin Binding Regulation Of Organelle Organization Cytoplasm Cytoskeleton-dependent Intracellular Transport Protein Polymerization Positive Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis Axon Protein Localization To Organelle Transport Along Microtubule Regulation Of Protein Localization Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Growth Regulation Of Cellular Response To Stress Apoptotic Process Dendrite Alpha-tubulin Binding Regulation Of Microtubule-based Process Tau Protein Binding Synapse Programmed Cell Death Cell Death Microtubule-based Transport Regulation Of Microtubule Cytoskeleton Organization Axo-dendritic Transport Regulation Of Intracellular Signal Transduction Cilium Disassembly
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