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YWHAZ and TSC1
Number of citations of the paper that reports this interaction (PubMedID
35271311
)
106
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
YWHAZ
TSC1
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
TSC complex subunit 1
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Focal Adhesion
Vesicle
Melanosome
Extracellular Exosome
Blood Microparticle
Hippocampal Mossy Fiber To CA3 Synapse
Glutamatergic Synapse
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Protein-containing Complex
TSC1-TSC2 Complex
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Protein Folding Chaperone Complex
Molecular Function
RNA Binding
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Transmembrane Transporter Binding
Cadherin Binding
Phosphoserine Residue Binding
DNA-binding Transcription Factor Binding
Protein Sequestering Activity
Protein Binding
Hsp70 Protein Binding
ATPase Inhibitor Activity
Protein Folding Chaperone
Protein-folding Chaperone Binding
Hsp90 Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Respiratory System Process
Protein Phosphorylation
Protein Targeting
Lysosome Organization
Signal Transduction
Synaptic Target Recognition
Intracellular Protein Localization
Lung Development
Regulation Of Protein Stability
Cellular Response To Nutrient Levels
Tube Formation
TORC1 Signaling
Cellular Response To Glucose Starvation
Negative Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Negative Regulation Of Innate Immune Response
Establishment Of Golgi Localization
ERK1 And ERK2 Cascade
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Synapse Maturation
Golgi Reassembly
Antibacterial Innate Immune Response
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of TORC1 Signaling
Regulation Of Lysosome Organization
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
Protein Folding
Potassium Ion Transport
Cell-matrix Adhesion
Nervous System Development
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Associative Learning
Adult Locomotory Behavior
Cellular Response To Starvation
Negative Regulation Of Macroautophagy
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATP-dependent Activity
Response To Insulin
Cellular Response To Decreased Oxygen Levels
TORC1 Signaling
Myelination
Memory T Cell Differentiation
Negative Regulation Of Cell Size
D-glucose Import
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Deactivation of the beta-catenin transactivating complex
Rap1 signalling
GP1b-IX-V activation signalling
KSRP (KHSRP) binds and destabilizes mRNA
Interleukin-3, Interleukin-5 and GM-CSF signaling
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
NOTCH4 Activation and Transmission of Signal to the Nucleus
Negative regulation of NOTCH4 signaling
Regulation of localization of FOXO transcription factors
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Transcriptional and post-translational regulation of MITF-M expression and activity
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Drugs
Phenethyl Isothiocyanate
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Adventurousness (
30643258
)
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Body mass index (
25673413
)
Chronotype (
30696823
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
General risk tolerance (MTAG) (
30643258
)
High light scatter reticulocyte count (
32888494
)
Interleukin-10 levels (
22205395
)
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Interacting Genes
204 interacting genes:
AANAT
ABL1
ADAM22
ADRA2A
ADRA2B
ADRA2C
AKAP13
AKT1
APP
ARHGEF2
ATP5F1A
ATXN1
BAD
BCAR1
BCR
BRAF
BSPRY
CBL
CCDC125
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK16
CDK17
CDKN1B
CEP126
CEP131
CFL1
CGNL1
CLIC4
COP1
CPAP
CRBN
CRTC2
CSF2RB
CSNK1A1
CSNK1D
DFFA
DISC1
EFNB3
EGFR
EIF3A
ENO1
EP300
EPB41L1
EPB41L3
ERBB2
ERBB3
EXO1
FAM13B
FHOD1
FNDC3B
FOXO1
FOXO3
FOXO4
GABARAPL2
GABBR1
GCH1
GP1BA
GP1BB
GP5
GSK3B
HDAC4
HDAC9
HMGN1
HSP90AA1
HSPA1A
HSPA1B
HSPB1
HSPB6
IGF1R
IL9R
ING1
INPP5A
IRAG2
IRS1
IRS2
KANK1
KCNK15
KCNK3
KCNK9
KIAA0232
KIAA0930
KIF1C
KIF5B
KLC2
KLC4
KLF11
KRT18
KSR1
LARP1
LATS2
LCP2
LIMK1
LNX1
MADD
MAP2K5
MAP3K2
MAP3K20
MAP3K3
MAP3K4
MAP3K5
MAPK8
MAPKAPK2
MAPT
MARK2
MARK3
MARK4
MDM4
MEF2C
MINK1
MLF1
MPHOSPH9
MSL2
MST1R
MTNR1A
MYH9
NCAM2
NEDD4L
NFATC2
NFATC4
NR4A1
PAK1
PAK4
PARD3
PARD6A
PARD6B
PCNT
PDC
PFKFB2
PIAS1
PPP1CC
PPP1R14A
PPP1R3D
PRKACA
PRKAR1A
PRKCA
PRKCD
PRKCI
PRKCZ
PRLR
PRMT5
PSMA5
PTPN13
PTPRO
RAF1
RALGPS2
RAP1GAP2
RASAL3
REM1
RGS3
RIN1
RPRD1A
RRAD
SAMSN1
SH3GL1
SIK1
SIK3
SIMC1
SLC8A2
SNAPIN
SNX24
SORBS2
SQSTM1
SSX2IP
STK25
STK38
SYN2
SYNPO
SYNPO2
TAB2
TBC1D7
TBXA2R
TERT
TH
TJP2
TLK2
TNFAIP3
TNS1
TP53
TPD52L1
TPH1
TRA2B
TRIM21
TSC1
TSC2
TUBB
UBC
UCHL5
UCP2
UCP3
USP8
VCP
VIM
WEE1
WNK1
WNK2
WWTR1
XRCC6
YAP1
YWHAE
ZNF839
169 interacting genes:
ABI1
ACTN1
ACTN2
AKT1
ANKIB1
ANKRD24
ANKRD35
APPL2
AQP1
ARAF
ARID5A
ATN1
ATXN1
AURKA
AXIN1
BAG3
BCL11A
BECN1
BEND5
C1orf94
CALCOCO2
CASC3
CCDC120
CCDC88B
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CDR2
CHCHD2
CNIH1
CNTRL
CNTROB
COG6
CSTF2
CTNNB1
DACH2
DCTN2
DMRT3
DOK5
EIF3A
ENKD1
EZR
FAM110A
FAM222B
FBF1
FGFR4
FOXH1
FRS3
GCC1
GEMIN8
GFAP
GLIS2
GOLGA2
GPANK1
GPATCH1
HECW1
HGS
HNRNPM
HOMER3
HOOK2
HOXC8
HR
HSH2D
ICA1
IGFN1
IKBKB
KANSL2
KAT2A
KAZN
KDM1A
KIF1C
KIF5A
KLC1
KLC4
LATS2
LENG1
LMO2
LRSAM1
LUC7L
LZTS2
MAP2K5
MAPK14
MBIP
MBP
MSANTD3
MSN
MT-ND1
MYC
MYLIP
MYOZ3
NECAB2
NEFL
NF2
NINL
NKD2
NRBF2
PATL1
PATZ1
PHLDB1
PICK1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPFIA2
PPP1R18
PRMT6
RALYL
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
RUNDC3A
SAMD11
SAMD7
SAXO4
SCMH1
SEC31A
SELENOW
SERTAD1
SH2D2A
SHANK1
SHC3
SMG9
SORBS3
SOX4
SPAG5
SPAG8
SUOX
TANK
TBC1D7
TBX6
TCF7L2
TFAP2D
TFIP11
TLE5
TNS2
TRIM3
TRIOBP
TSC2
TSGA10IP
TSHZ3
USP2-AS1
VENTX
VEZF1
VGLL3
VIM
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF423
ZNF587
ZNF765
Entrez ID
7534
7248
HPRD ID
03183
05594
Ensembl ID
ENSG00000164924
ENSG00000165699
Uniprot IDs
D0PNI1
P63104
A0A2R8Y5M3
A0A2R8Y5N2
A0A2R8Y5S3
A0A2R8Y6S1
A0A2R8YD74
A0A2R8YFV7
Q32NF0
Q86WV8
Q92574
X5D9D2
PDB IDs
1IB1
1QJA
1QJB
2C1J
2C1N
2O02
2WH0
3CU8
3NKX
3RDH
4BG6
4FJ3
4HKC
4IHL
4N7G
4N7Y
4N84
4WRQ
4ZDR
5D2D
5D3F
5EWZ
5EXA
5J31
5JM4
5M35
5M36
5M37
5NAS
5ULO
5WXN
5XY9
6EF5
6EJL
6EWW
6F08
6F09
6FN9
6FNA
6FNB
6FNC
6Q0K
6RLZ
6U2H
6XAG
6YMO
6YO8
6YOS
6ZFD
6ZFG
7D8H
7D8P
7D9V
7MFD
7MFE
7MFF
7Q16
7ZIT
8A9G
8AH2
8QDV
8WE2
8WF6
9FUM
9FVL
4Z6Y
5EJC
7DL2
9C9I
9CE3
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Intracellular Signal Transduction
Protein Kinase Activity
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Protein Phosphorylation
Cytosol
Regulation Of Intracellular Signal Transduction
Phosphorylation
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Signal Transduction
Positive Regulation Of Signal Transduction
ATP Binding
Intracellular Signaling Cassette
Regulation Of Protein Modification Process
Protein Modification Process
Regulation Of Cellular Component Organization
Regulation Of Programmed Cell Death
Nucleotide Binding
Regulation Of Protein Localization
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Apoptotic Process
Positive Regulation Of Protein Metabolic Process
Transferase Activity
Positive Regulation Of Intracellular Signal Transduction
Cellular Response To Stress
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Signal Transduction
Cellular Response To Oxygen-containing Compound
Regulation Of Phosphorus Metabolic Process
Regulation Of Multicellular Organismal Process
Protein Kinase Binding
Phosphate-containing Compound Metabolic Process
Positive Regulation Of Protein Localization
Protein Metabolic Process
Regulation Of Cell Cycle
Cell Surface Receptor Signaling Pathway
Response To Stress
Protein-containing Complex
MAPK Cascade
Positive Regulation Of Cellular Component Organization
Cytoskeleton
Protein Domain Specific Binding
Regulation Of Primary Metabolic Process
Cytoplasm
Protein Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Protein Localization To Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Spindle Pole
Microtubule-based Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Microtubule Cytoskeleton Organization
Negative Regulation Of Biosynthetic Process
Protein Kinase Binding
Negative Regulation Of Macromolecule Metabolic Process
Identical Protein Binding
Cytoskeleton Organization
Organelle Organization
Negative Regulation Of Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Intracellular Transport
Cell Cycle G1/S Phase Transition
Mitotic Cell Cycle Phase Transition
Cytoskeletal Protein Binding
Cytosol
Regulation Of Protein Localization
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Transcription By RNA Polymerase II
Microtubule Cytoskeleton Organization Involved In Mitosis
MAPK Cascade
Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Early Endosome To Late Endosome Transport
Centrosome
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Tagcloud (Intersection)
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