YWHAZ and CSNK1A1

Number of citations of the paper that reports this interaction (PubMedID 9360956)
0

Data Source:
HPRD (in vivo)

		YWHAZ	CSNK1A1
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	casein kinase 1 alpha 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Vesicle Melanosome Extracellular Exosome Blood Microparticle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Centrosome Spindle Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cytoskeleton Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Cell Projection Keratin Filament
	Molecular Function	RNA Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Transmembrane Transporter Binding Cadherin Binding Phosphoserine Residue Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Respiratory System Process Protein Phosphorylation Protein Targeting Lysosome Organization Signal Transduction Synaptic Target Recognition Intracellular Protein Localization Lung Development Regulation Of Protein Stability Cellular Response To Nutrient Levels Tube Formation TORC1 Signaling Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Innate Immune Response Establishment Of Golgi Localization ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Regulation Of Synapse Maturation Golgi Reassembly Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of TORC1 Signaling Regulation Of Lysosome Organization	Autophagosome Assembly Protein Phosphorylation Golgi Organization Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Wnt Signaling Pathway Viral Protein Processing Regulation Of Wnt Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Nutrient Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rho Protein Signal Transduction TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Maturation of nucleoprotein
Drugs		Phenethyl Isothiocyanate	Fostamatinib
Diseases
GWAS		Adventurousness ( 30643258) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Body mass index ( 25673413) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) General risk tolerance (MTAG) ( 30643258) High light scatter reticulocyte count ( 32888494) Interleukin-10 levels ( 22205395)	Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)
Interacting Genes		204 interacting genes: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARHGEF2 ATP5F1A ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CEP126 CEP131 CFL1 CGNL1 CLIC4 COP1 CPAP CRBN CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EP300 EPB41L1 EPB41L3 ERBB2 ERBB3 EXO1 FAM13B FHOD1 FNDC3B FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 GSK3B HDAC4 HDAC9 HMGN1 HSP90AA1 HSPA1A HSPA1B HSPB1 HSPB6 IGF1R IL9R ING1 INPP5A IRAG2 IRS1 IRS2 KANK1 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LATS2 LCP2 LIMK1 LNX1 MADD MAP2K5 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MTNR1A MYH9 NCAM2 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PCNT PDC PFKFB2 PIAS1 PPP1CC PPP1R14A PPP1R3D PRKACA PRKAR1A PRKCA PRKCD PRKCI PRKCZ PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RGS3 RIN1 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNAPIN SNX24 SORBS2 SQSTM1 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBC1D7 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UCHL5 UCP2 UCP3 USP8 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YAP1 YWHAE ZNF839	51 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC ATM AXIN1 BID CDC25A CEBPA CHRM3 CRBN CREM CTNNB1 CUL4B EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MDM4 NFATC3 NLRP3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 USP15 UVRAG YWHAQ YWHAZ
Entrez ID		7534	1452
HPRD ID		03183	02739
Ensembl ID		ENSG00000164924	ENSG00000113712
Uniprot IDs		D0PNI1 P63104	B4DER9 P48729 Q6PJ06
PDB IDs		1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL 4N7G 4N7Y 4N84 4WRQ 4ZDR 5D2D 5D3F 5EWZ 5EXA 5J31 5JM4 5M35 5M36 5M37 5NAS 5ULO 5WXN 5XY9 6EF5 6EJL 6EWW 6F08 6F09 6FN9 6FNA 6FNB 6FNC 6Q0K 6RLZ 6U2H 6XAG 6YMO 6YO8 6YOS 6ZFD 6ZFG 7D8H 7D8P 7D9V 7MFD 7MFE 7MFF 7Q16 7ZIT 8A9G 8AH2 8QDV 8WE2 8WF6 9FUM 9FVL	5FQD 6GZD 7WTT 8G66
Enriched GO Terms of Interacting Partners?		Cytoplasm Intracellular Signal Transduction Protein Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Cytosol Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Signal Transduction ATP Binding Intracellular Signaling Cassette Regulation Of Protein Modification Process Protein Modification Process Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Nucleotide Binding Regulation Of Protein Localization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process Transferase Activity Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Phosphorus Metabolic Process Regulation Of Multicellular Organismal Process Protein Kinase Binding Phosphate-containing Compound Metabolic Process Positive Regulation Of Protein Localization Protein Metabolic Process Regulation Of Cell Cycle Cell Surface Receptor Signaling Pathway Response To Stress Protein-containing Complex MAPK Cascade Positive Regulation Of Cellular Component Organization	Protein-containing Complex Signal Transduction Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Development Ubiquitin Protein Ligase Binding Protein Domain Specific Binding Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Development Cytosol Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Cellular Component Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of T Cell Activation Regulation Of Metabolic Process Regulation Of Stem Cell Proliferation T Cell Differentiation In Thymus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Lung Development Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Intracellular Signaling Cassette Cytoplasm Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Apoptotic Process
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