YWHAH and PTH1R

Number of citations of the paper that reports this interaction (PubMedID 12595070)
0

Data Source:
HPRD (in vivo, in vitro)

		YWHAH	PTH1R
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	parathyroid hormone 1 receptor
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Cerebellar Granule Cell To Purkinje Cell Synapse	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Receptor Complex
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Protein Heterodimerization Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Signal Transduction Intracellular Protein Localization Substantia Nigra Development Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Depolarization During Action Potential Presynaptic Modulation Of Chemical Synaptic Transmission	Skeletal System Development Ossification In Utero Embryonic Development Chondrocyte Differentiation Osteoblast Development Intracellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs		Phenethyl Isothiocyanate	Abaloparatide Parathyroid hormone Teriparatide
Diseases			Eiken dysplasia Blomstrand syndrome; Blomstrand chondrodysplasia Primary failure of tooth eruption Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)	Birth weight ( 27680694 31043758) Hip circumference adjusted for BMI ( 34021172) Microalbuminuria ( 26631737) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 2 diabetes ( 30054458) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		69 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ILF3 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCAM2 NCOA1 NCOA2 NCOA3 NEDD4L NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PCNT PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	16 interacting genes: ARRB1 GNB1 GPANK1 GUCD1 HOXA1 MGAT5B MKRN3 NHERF1 NHERF2 PTH PTHLH SMARCC1 STK16 TEKT4 UBC YWHAH
Entrez ID		7533	5745
HPRD ID		00215	01347
Ensembl ID		ENSG00000128245	ENSG00000160801
Uniprot IDs		Q04917 Q9H4N8	Q03431 Q0VGD7
PDB IDs		2C63 2C74 7NMZ	1BL1 3C4M 3H3G 3L2J 4Z8J 5EMB 6NBF 6NBH 6NBI 7UZO 7UZP 7VVJ 7VVK 7VVL 7VVM 7VVN 7VVO 7Y35 7Y36 8BIA 8BJ0 8D51 8D52 8FLQ 8FLR 8FLS 8FLT 8FLU 8GW8 8HA0 8HAF 8HAO 8JR9 9JR2 9JR3
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Nuclear Receptor-mediated Signaling Pathway Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Biological Quality PAR Polarity Complex Regulation Of Intracellular Signal Transduction Regulation Of Transport Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Regulation Of Membrane Potential Regulation Of Apoptotic Process Regulation Of Vesicle-mediated Transport Cell Junction Organization Negative Regulation Of Apoptotic Process Phosphorylation Positive Regulation Of Metabolic Process Enzyme Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Lipid Cellular Response To Hormone Stimulus Hormone-mediated Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Anatomical Structure Morphogenesis Developmental Process Cytoskeleton Organization Cellular Response To Lipid Positive Regulation Of Intracellular Signal Transduction Regulation Of Secretion By Cell Regulation Of Phosphorus Metabolic Process Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Protein Serine/threonine Kinase Activity Synaptic Vesicle Priming Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein Kinase Activity	Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Peptide Hormone Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Insulin-like Growth Factor Receptor Binding Phosphate Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Negative Regulation Of Chondrocyte Differentiation CAMP Metabolic Process Negative Regulation Of Cartilage Development Protein-membrane Adaptor Activity Sensory Perception Molecular Adaptor Activity Semicircular Canal Formation Cyclic Purine Nucleotide Metabolic Process Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Glucocorticoid Catabolic Process Renal Phosphate Ion Absorption Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Regulation Of Chondrocyte Differentiation Phosphatase Binding Bone Mineralization Angiotensin Receptor Binding Abducens Nerve Formation Optokinetic Behavior Regulation Of Sodium Ion Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding
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