YWHAH and RPH3A

Number of citations of the paper that reports this interaction (PMID 12871946)
12

Data Source:
HPRD (in vitro)

		YWHAH	RPH3A
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta	rabphilin 3A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Intercalated Disc Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Golgi Apparatus Cytosol Synaptic Vesicle Extrinsic Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane Neuron Projection Protein Complex Synapse
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Ion Channel Binding Protein Heterodimerization Activity	Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Zinc Ion Binding Selenium Binding Rab GTPase Binding Protein Complex Binding Phosphate Ion Binding Inositol 1,4,5 Trisphosphate Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Apoptotic Process Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity	Intracellular Protein Transport
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS			Platelet counts ( 22139419)
Protein-Protein Interactions		61 interactors: ABL1 ARHGEF28 BAD BCR BRAF CDC25B CDC25C CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 ING1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NR3C1 NRIP1 PARD3 PARD6A PARD6B PARK2 PDPK1 PRKCI PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	10 interactors: ADD2 CASK GCH1 NRXN1 RAB15 RAB27A RAB3A RAB3B RAB8A YWHAH
Entrez ID		7533	22895
HPRD ID		00215	15273
Ensembl ID		ENSG00000128245	ENSG00000089169
Uniprot IDs		Q04917 Q9H4N8	Q9Y2J0
PDB IDs		2C63 2C74
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Regulation Of Kinase Activity Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorus Metabolic Process System Development Multicellular Organismal Development Regulation Of Protein Phosphorylation Cellular Response To Stimulus Regulation Of Cell Death Regulation Of Protein Kinase Activity Regulation Of Cellular Process Response To Organic Substance Regulation Of Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Organelle Organization Cell Cycle Negative Regulation Of Cellular Metabolic Process Response To Organonitrogen Compound Apoptotic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Programmed Cell Death Response To Growth Factor	Rab Protein Signal Transduction Vesicle Docking Involved In Exocytosis Vesicle Docking Membrane Docking Protein Secretion Secretion Regulation Of Exocytosis Vesicle Localization Ras Protein Signal Transduction Secretion By Cell Regulation Of Cellular Localization Positive Regulation Of Regulated Secretory Pathway Regulation Of Secretion Neurotransmitter Secretion Regulation Of Synaptic Transmission Synaptic Vesicle Transport Exocytosis Positive Regulation Of Transport Cellular Protein Localization Regulation Of Vesicle-mediated Transport Regulation Of Neurotransmitter Levels Establishment Of Protein Localization Organelle Localization Neurotransmitter Transport Regulation Of Regulated Secretory Pathway Intracellular Protein Transport Establishment Of Vesicle Localization Synaptic Vesicle Exocytosis Positive Regulation Of Exocytosis Synaptic Transmission Protein Localization Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Establishment Of Organelle Localization Protein Transport Cellular Localization Intracellular Transport Cell-cell Signaling Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Ion Transport Transport Vesicle-mediated Transport Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Secretion Membrane Organization Protein Localization To Membrane Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of Constitutive Secretory Pathway Protein Complex Assembly Involved In Synapse Maturation
Tagcloud ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	abeta25 cholinergic deafferentation downregulated dysfunction exocytosis immunoreactivity interacts involve neocortex neuritic neurofibrillary neuron neurotransmitter plaques postmortem postsynaptic presynaptic rab3a rabphilin reductions selectively snare synaptic synaptopathology tangles triggered vesicle
Tagcloud (Difference) ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	abeta25 cholinergic deafferentation downregulated dysfunction exocytosis immunoreactivity interacts involve neocortex neuritic neurofibrillary neuron neurotransmitter plaques postmortem postsynaptic presynaptic rab3a rabphilin reductions selectively snare synaptic synaptopathology tangles triggered vesicle
Tagcloud (Intersection) ?