YWHAH and CHRNA4

Number of citations of the paper that reports this interaction (PubMedID 11352901)
0

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		YWHAH	CHRNA4
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	cholinergic receptor nicotinic alpha 4 subunit
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Cerebellar Granule Cell To Purkinje Cell Synapse	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Dendrite Cation Channel Complex Presynaptic Membrane Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane Synaptic Membrane Neurotransmitter Receptor Complex
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Protein Heterodimerization Activity	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Signal Transduction Intracellular Protein Localization Substantia Nigra Development Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Depolarization During Action Potential Presynaptic Modulation Of Chemical Synaptic Transmission	Action Potential Response To Hypoxia DNA Repair Chromatin Remodeling Monoatomic Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Dopamine Secretion Sensory Perception Of Pain Monoatomic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine B Cell Activation Regulation Of Membrane Potential Nervous System Process Cognition Membrane Depolarization Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Phenethyl Isothiocyanate	Nicotine Succinylcholine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Carbamazepine Cisatracurium Atropine Thiopental Mecamylamine Scopolamine Isoflurane Estradiol Primidone Methylphenobarbital Ethanol Amantadine Physostigmine Phenobarbital Decamethonium Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Pozanicline RPI-78M Epibatidine Cytisine Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases			Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)	Chronic obstructive pulmonary disease ( 19300482) Emphysema imaging phenotypes ( 26030696) Nicotine dependence ( 26440539 28972577 33144568) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 30617275 30679032) Smoking cessation ( 33082346) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		69 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ILF3 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCAM2 NCOA1 NCOA2 NCOA3 NEDD4L NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PCNT PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	10 interacting genes: CHRNB2 CHRNB4 CRELD2 CSNK2B RAPSN RHOU SNCA UBQLN1 VSNL1 YWHAH
Entrez ID		7533	1137
HPRD ID		00215	00333
Ensembl ID		ENSG00000128245	ENSG00000101204
Uniprot IDs		Q04917 Q9H4N8	B4DK78 P43681 Q4VAQ3 Q59FV0
PDB IDs		2C63 2C74 7NMZ	2LLY 5KXI 6CNJ 6CNK 6UR8 6USF 8SSZ 8ST0 8ST1 8ST2 8ST3 8ST4
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Nuclear Receptor-mediated Signaling Pathway Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Biological Quality PAR Polarity Complex Regulation Of Intracellular Signal Transduction Regulation Of Transport Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Regulation Of Membrane Potential Regulation Of Apoptotic Process Regulation Of Vesicle-mediated Transport Cell Junction Organization Negative Regulation Of Apoptotic Process Phosphorylation Positive Regulation Of Metabolic Process Enzyme Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Lipid Cellular Response To Hormone Stimulus Hormone-mediated Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Anatomical Structure Morphogenesis Developmental Process Cytoskeleton Organization Cellular Response To Lipid Positive Regulation Of Intracellular Signal Transduction Regulation Of Secretion By Cell Regulation Of Phosphorus Metabolic Process Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Protein Serine/threonine Kinase Activity Synaptic Vesicle Priming Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein Kinase Activity	Synaptic Transmission, Cholinergic Synaptic Transmission Involved In Micturition Regulation Of Cell Communication Membrane Depolarization Regulation Of Signaling Modulation Of Chemical Synaptic Transmission Excitatory Postsynaptic Potential Behavioral Response To Nicotine Acetylcholine Receptor Activity Neurotransmitter Receptor Complex Trans-synaptic Signaling Acetylcholine-gated Monoatomic Cation-selective Channel Activity Regulation Of Postsynaptic Membrane Potential Chemical Synaptic Transmission Synaptic Signaling Acetylcholine-gated Channel Complex Cation Channel Complex Regulation Of Dopamine Metabolic Process Regulation Of Dopamine Secretion Regulation Of Membrane Potential Adult Behavior Regulation Of Transport Synapse Postsynaptic Specialization Membrane Ligand-gated Monoatomic Ion Channel Activity Locomotory Behavior Regulation Of Biological Quality Neuromuscular Synaptic Transmission Extracellular Ligand-gated Monoatomic Ion Channel Activity Regulation Of Secretion By Cell Protein-macromolecule Adaptor Activity Regulation Of Catecholamine Secretion Response To Cocaine Cell-cell Signaling Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Protein Domain Specific Binding Response To Nicotine Regulation Of Secretion Signaling Postsynaptic Signal Transduction Cell Communication Smooth Muscle Contraction Regulation Of Dendrite Morphogenesis Neural Nucleus Development Positive Regulation Of Secretion By Cell Lateral Geniculate Nucleus Development Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity
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