YWHAH and CHRNA4

Number of citations of the paper that reports this interaction (PMID 11352901)
41

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		YWHAH	CHRNA4
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta	cholinergic receptor, nicotinic, alpha 4 (neuronal)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Intercalated Disc Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Integral Component Of Membrane Cell Junction Dendrite Neuronal Cell Body Postsynaptic Membrane
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Ion Channel Binding Protein Heterodimerization Activity	Acetylcholine-activated Cation-selective Channel Activity Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Apoptotic Process Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity	Action Potential Response To Hypoxia DNA Repair Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Respiratory Gaseous Exchange Locomotory Behavior Regulation Of Dopamine Secretion Sensory Perception Of Pain Response To Nicotine Behavioral Response To Nicotine Exploration Behavior B Cell Activation Regulation Of Membrane Potential Neurological System Process Cognition Membrane Depolarization Regulation Of Inhibitory Postsynaptic Membrane Potential Cation Transmembrane Transport
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses
Drugs			Nicotine Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Galantamine Primidone Methylphenobarbital Phenobarbital Varenicline Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative
Diseases
GWAS			Chronic obstructive pulmonary disease ( 19300482)
Protein-Protein Interactions		61 interactors: ABL1 ARHGEF28 BAD BCR BRAF CDC25B CDC25C CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 ING1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NR3C1 NRIP1 PARD3 PARD6A PARD6B PARK2 PDPK1 PRKCI PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	7 interactors: CHRNB2 CHRNB4 CRELD2 CSNK2B UBQLN1 VSNL1 YWHAH
Entrez ID		7533	1137
HPRD ID		00215	00333
Ensembl ID		ENSG00000128245	ENSG00000101204
Uniprot IDs		Q04917 Q9H4N8	B4DK78 P43681 Q4VAQ3 Q4VAQ5 Q59FV0
PDB IDs		2C63 2C74	2GVT 2LLY
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Regulation Of Kinase Activity Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorus Metabolic Process System Development Multicellular Organismal Development Regulation Of Protein Phosphorylation Cellular Response To Stimulus Regulation Of Cell Death Regulation Of Protein Kinase Activity Regulation Of Cellular Process Response To Organic Substance Regulation Of Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Organelle Organization Cell Cycle Negative Regulation Of Cellular Metabolic Process Response To Organonitrogen Compound Apoptotic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Programmed Cell Death Response To Growth Factor	Synaptic Transmission Involved In Micturition Micturition Action Potential Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Membrane Potential Response To Nicotine Regulation Of Synaptic Transmission Excretion Neural Nucleus Development Smooth Muscle Contraction Regulation Of Dendrite Morphogenesis Regulation Of Signaling Renal System Process Lateral Geniculate Nucleus Development Glucocorticoid Catabolic Process Regulation Of Dendrite Development Membrane Depolarization Cellular Response To Stimulus Response To Alkaloid Adult Behavior Negative Regulation Of Action Potential Muscle Contraction Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Dopamine Secretion Locomotory Behavior Regulation Of Cellular Localization Conditioned Taste Aversion Response To Stimulus Muscle System Process Positive Regulation Of Activin Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Dendrite Morphogenesis Response To Hypoxia Vestibulocochlear Nerve Development Positive Regulation Of Synaptic Transmission, Dopaminergic Optic Nerve Morphogenesis Signal Transduction Endothelial Tube Morphogenesis Positive Regulation Of Catecholamine Secretion Optic Nerve Development Signaling Regulation Of Neuron Projection Development Thalamus Development Cell Communication Negative Regulation Of Dendrite Development Glucocorticoid Metabolic Process
Tagcloud ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	adrenal axis bcl1 beck besides carriers cc cholinergic depression depressiveness disruption epistasis genetics genotyped glucocorticoid glucocorticoids homozygous hypothalamic impacts inventory locus means nr3c1 pituitary polymorphisms reactivity rs1044396 rs41423247 showing
Tagcloud (Difference) ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	adrenal axis bcl1 beck besides carriers cc cholinergic depression depressiveness disruption epistasis genetics genotyped glucocorticoid glucocorticoids homozygous hypothalamic impacts inventory locus means nr3c1 pituitary polymorphisms reactivity rs1044396 rs41423247 showing
Tagcloud (Intersection) ?