PTH1R and ARRB1

Number of citations of the paper that reports this interaction (PMID 12220636)
1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PTH1R	ARRB1
Gene Name		parathyroid hormone 1 receptor	arrestin, beta 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Coated Pit Cytoplasmic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle
	Molecular Function	Parathyroid Hormone Receptor Activity Protein Binding Peptide Hormone Binding Protein Self-association	Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Transcription Regulatory Region DNA Binding
	Biological Process	Skeletal System Development Chondrocyte Differentiation Osteoblast Development G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process	Positive Regulation Of Protein Phosphorylation G-protein Coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription From RNA Polymerase II Promoter Post-Golgi Vesicle-mediated Transport Notch Signaling Pathway Blood Coagulation Phototransduction Protein Transport Protein Ubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Histone Acetylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of GTPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Histone H4 Acetylation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Golgi Associated Vesicle Biogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Platelet activation, signaling and aggregation trans-Golgi Network Vesicle Budding FBXW7 Mutants and NOTCH1 in Cancer Activation of SMO
Drugs
Diseases
GWAS			Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		8 interactors: ARRB1 GNB1 PTH PTHLH SLC9A3R1 SLC9A3R2 UBC YWHAH	52 interactors: ADH6 ADRB1 ADRB2 ADRBK1 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CSK CXCR2 CYTH2 DVL1 DVL2 FGR FLNA GNB1 GNMT GPR50 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK9 NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 PTAFR PTH1R PTHLH RALGDS RPL15 SLC9A5 SREBF2 STAM TRHR ZBTB43
Entrez ID		5745	408
HPRD ID		01347	00146
Ensembl ID		ENSG00000160801	ENSG00000137486
Uniprot IDs		Q03431 Q0VGD7	B7Z1Q3 P49407
PDB IDs		1BL1 1ET2 1ET3 3C4M 3H3G 3KJ5 3L2J	2IV8
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Programmed Cell Death Cell Death Death Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Signal Transduction Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Phosphorus Metabolic Process Dopamine Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Cellular Biosynthetic Process CAMP Metabolic Process Chemical Homeostasis Cell Surface Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Signal Transduction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Regulation Of Sodium Ion Transport Positive Regulation Of CAMP Metabolic Process Negative Regulation Of Signal Transduction Signaling Cyclic Nucleotide Metabolic Process Cell Communication G-protein Coupled Receptor Signaling Pathway Renal Phosphate Ion Absorption Glucocorticoid Catabolic Process Nipple Sheath Formation Mammary Gland Bud Elongation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Ion Homeostasis Negative Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of CAMP Biosynthetic Process Phototransduction Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of CAMP Metabolic Process Negative Regulation Of Protein Ubiquitination Detection Of Light Stimulus Positive Regulation Of Transcription, DNA-templated Cellular Chemical Homeostasis Cellular Response To Oxygen Levels	Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Signal Transduction Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune Response Innate Immune Response Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Phosphorus Metabolic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Immune Response Intracellular Signal Transduction Defense Response Activation Of Innate Immune Response Regulation Of Signal Transduction Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Regulation Of Signaling Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Response To Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Regulation Of Protein Phosphorylation Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process
Tagcloud ?		293a arrestin arrestin1 b2r bona cargo cargoes cognate colocalization construction cytofluorometric egfp endosomal fide gpcrs hek internalization internalize lysate maximakinin mk preproinsulin rab5 rab7 recipient secretable transporting verify	11q13 adrenergic apparently ark ark1 arrestin beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates
Tagcloud (Difference) ?		293a arrestin1 b2r bona cargo cargoes cognate colocalization construction cytofluorometric egfp endosomal fide gpcrs hek internalization internalize lysate maximakinin mk preproinsulin rab5 rab7 recipient secretable transporting verify	11q13 adrenergic apparently ark ark1 beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates
Tagcloud (Intersection) ?		arrestin