PTH1R and SLC9A3R1

Number of citations of the paper that reports this interaction (PMID 12075354)
61

Data Source:
HPRD (in vitro, in vivo)

		PTH1R	SLC9A3R1
Gene Name		parathyroid hormone 1 receptor	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece
	Molecular Function	Parathyroid Hormone Receptor Activity Protein Binding Peptide Hormone Binding Protein Self-association	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding
	Biological Process	Skeletal System Development Chondrocyte Differentiation Osteoblast Development G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Fibrinogen ( 20031577)
Protein-Protein Interactions		8 interactors: ARRB1 GNB1 PTH PTHLH SLC9A3R1 SLC9A3R2 UBC YWHAH	52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468
Entrez ID		5745	9368
HPRD ID		01347	05406
Ensembl ID		ENSG00000160801	ENSG00000109062
Uniprot IDs		Q03431 Q0VGD7	O14745
PDB IDs		1BL1 1ET2 1ET3 3C4M 3H3G 3KJ5 3L2J	1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Programmed Cell Death Cell Death Death Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Signal Transduction Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Phosphorus Metabolic Process Dopamine Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Cellular Biosynthetic Process CAMP Metabolic Process Chemical Homeostasis Cell Surface Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Signal Transduction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Regulation Of Sodium Ion Transport Positive Regulation Of CAMP Metabolic Process Negative Regulation Of Signal Transduction Signaling Cyclic Nucleotide Metabolic Process Cell Communication G-protein Coupled Receptor Signaling Pathway Renal Phosphate Ion Absorption Glucocorticoid Catabolic Process Nipple Sheath Formation Mammary Gland Bud Elongation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Ion Homeostasis Negative Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of CAMP Biosynthetic Process Phototransduction Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of CAMP Metabolic Process Negative Regulation Of Protein Ubiquitination Detection Of Light Stimulus Positive Regulation Of Transcription, DNA-templated Cellular Chemical Homeostasis Cellular Response To Oxygen Levels	Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process
Tagcloud ?		293a arrestin arrestin1 b2r bona cargo cargoes cognate colocalization construction cytofluorometric egfp endosomal fide gpcrs hek internalization internalize lysate maximakinin mk preproinsulin rab5 rab7 recipient secretable transporting verify	adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted
Tagcloud (Difference) ?		293a arrestin arrestin1 b2r bona cargo cargoes cognate colocalization construction cytofluorometric egfp endosomal fide gpcrs hek internalization internalize maximakinin mk preproinsulin rab5 rab7 recipient secretable transporting verify	adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted
Tagcloud (Intersection) ?		lysate