YWHAH and KCNK3

Number of citations of the paper that reports this interaction (PMID 12433946)
25

Data Source:
HPRD (in vivo, two hybrid)

		YWHAH	KCNK3
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta	potassium channel, two pore domain subfamily K, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Intercalated Disc Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Ion Channel Binding Protein Heterodimerization Activity	Ion Channel Activity Open Rectifier Potassium Channel Activity Potassium Channel Activity Protein C-terminus Binding Potassium Ion Leak Channel Activity Protein Homodimerization Activity S100 Protein Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Apoptotic Process Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity	Potassium Ion Transport Synaptic Transmission Brain Development Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Response To Drug Negative Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Zinc Ion Cellular Response To Hypoxia Potassium Ion Transmembrane Transport Cochlea Development
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis	TWIK-releated acid-sensitive K+ channel (TASK) Tandem pore domain potassium channels Potassium Channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ABL1 ARHGEF28 BAD BCR BRAF CDC25B CDC25C CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 ING1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NR3C1 NRIP1 PARD3 PARD6A PARD6B PARK2 PDPK1 PRKCI PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	9 interactors: COPB1 S100A10 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		7533	3777
HPRD ID		00215	04451
Ensembl ID		ENSG00000128245
Uniprot IDs		Q04917 Q9H4N8	O14649
PDB IDs		2C63 2C74
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Regulation Of Kinase Activity Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorus Metabolic Process System Development Multicellular Organismal Development Regulation Of Protein Phosphorylation Cellular Response To Stimulus Regulation Of Cell Death Regulation Of Protein Kinase Activity Regulation Of Cellular Process Response To Organic Substance Regulation Of Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Organelle Organization Cell Cycle Negative Regulation Of Cellular Metabolic Process Response To Organonitrogen Compound Apoptotic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Programmed Cell Death Response To Growth Factor	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Intracellular Transport Apoptotic Signaling Pathway Regulation Of Intracellular Transport Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Cellular Protein Localization Regulation Of Protein Localization Establishment Of Protein Localization Intracellular Protein Transport Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Protein Localization Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Protein Transport Cellular Localization Regulation Of Apoptotic Process Intracellular Transport Regulation Of Cell Death Protein Targeting Regulation Of Signal Transduction Substantia Nigra Development Intracellular Signal Transduction Regulation Of Signaling Neural Nucleus Development Establishment Of Localization In Cell Negative Regulation Of Protein Dephosphorylation Midbrain Development Transport Hippo Signaling Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Dephosphorylation Organelle Organization
Tagcloud ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	attenuation channels conductance dag determinants diacylglycerol downstream excitability galphaq gated gpcr gpcrs hormones initiated ip3 k2p kcnk9 links lipase messengers p2 phospholipase plc pore potassium subclass task transients transmitters
Tagcloud (Difference) ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	attenuation channels conductance dag determinants diacylglycerol downstream excitability galphaq gated gpcr gpcrs hormones initiated ip3 k2p kcnk9 links lipase messengers p2 phospholipase plc pore potassium subclass task transients transmitters
Tagcloud (Intersection) ?