YWHAH and TPH1

Number of citations of the paper that reports this interaction (PubMedID 7499362)
0

Data Source:
HPRD (in vitro)

		YWHAH	TPH1
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	tryptophan hydroxylase 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Cerebellar Granule Cell To Purkinje Cell Synapse	Cytoplasm Cytosol Neuron Projection
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Protein Heterodimerization Activity	Monooxygenase Activity Tryptophan 5-monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Metal Ion Binding
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Signal Transduction Intracellular Protein Localization Substantia Nigra Development Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Depolarization During Action Potential Presynaptic Modulation Of Chemical Synaptic Transmission	Platelet Degranulation Serotonin Biosynthetic Process From Tryptophan Aromatic Amino Acid Metabolic Process Serotonin Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Bone Remodeling Mammary Gland Alveolus Development Regulation Of Hemostasis
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Serotonin and melatonin biosynthesis NGF-stimulated transcription
Drugs		Phenethyl Isothiocyanate	Sapropterin LX1031 Telotristat ethyl
Diseases
GWAS		Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)	Glucose homeostasis traits ( 30576415) HDL cholesterol ( 30275531) White blood cell count ( 32888494)
Interacting Genes		69 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ILF3 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCAM2 NCOA1 NCOA2 NCOA3 NEDD4L NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PCNT PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	6 interacting genes: APP GORASP2 PRKACA PSTPIP1 YWHAH YWHAZ
Entrez ID		7533	7166
HPRD ID		00215	01846
Ensembl ID		ENSG00000128245	ENSG00000129167
Uniprot IDs		Q04917 Q9H4N8	P17752
PDB IDs		2C63 2C74 7NMZ	1MLW 3HF6 3HF8 3HFB 5J6D 5L01 5TPG 7ZIF 7ZIG 7ZIH 7ZII 7ZIJ 7ZIK 8CJI 8CJJ 8CJK 8CJL 8CJM 8CJN 8CJO
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Nuclear Receptor-mediated Signaling Pathway Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Biological Quality PAR Polarity Complex Regulation Of Intracellular Signal Transduction Regulation Of Transport Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Regulation Of Membrane Potential Regulation Of Apoptotic Process Regulation Of Vesicle-mediated Transport Cell Junction Organization Negative Regulation Of Apoptotic Process Phosphorylation Positive Regulation Of Metabolic Process Enzyme Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Lipid Cellular Response To Hormone Stimulus Hormone-mediated Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Anatomical Structure Morphogenesis Developmental Process Cytoskeleton Organization Cellular Response To Lipid Positive Regulation Of Intracellular Signal Transduction Regulation Of Secretion By Cell Regulation Of Phosphorus Metabolic Process Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Protein Serine/threonine Kinase Activity Synaptic Vesicle Priming Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein Kinase Activity	Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Neuron Recognition Regulation Of Metal Ion Transport TOR Signaling Protein Domain Specific Binding Negative Regulation Of TORC1 Signaling TORC1 Signaling Glucocorticoid Catabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of Calcium-mediated Signaling Establishment Of Protein Localization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Recognition Response To Stress Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Localization Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Establishment Of Localization In Cell Tube Formation Glutamatergic Synapse Transmembrane Transporter Binding Cerebellar Granule Cell To Purkinje Cell Synapse Synaptic Target Recognition Golgi Organization Regulation Of Calcium Ion Transmembrane Transport
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