YWHAH and TPH1

Number of citations of the paper that reports this interaction (PMID 7499362)
10

Data Source:
HPRD (in vitro)

		YWHAH	TPH1
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta	tryptophan hydroxylase 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Intercalated Disc Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Cytosol Neuron Projection
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Ion Channel Binding Protein Heterodimerization Activity	Tryptophan 5-monooxygenase Activity Iron Ion Binding Amino Acid Binding
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Apoptotic Process Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity	Circadian Rhythm Aromatic Amino Acid Family Metabolic Process Negative Regulation Of Ossification Cellular Nitrogen Compound Metabolic Process Response To Immobilization Stress Serotonin Biosynthetic Process Small Molecule Metabolic Process Positive Regulation Of Fat Cell Differentiation Indolalkylamine Biosynthetic Process Bone Remodeling Oxidation-reduction Process Mammary Gland Alveolus Development
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis	Amine-derived hormones Serotonin and melatonin biosynthesis Metabolism of amino acids and derivatives
Drugs			Tetrahydrobiopterin 7,8-Dihydro-L-Biopterin
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ABL1 ARHGEF28 BAD BCR BRAF CDC25B CDC25C CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 ING1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NR3C1 NRIP1 PARD3 PARD6A PARD6B PARK2 PDPK1 PRKCI PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	4 interactors: APP PRKACA YWHAH YWHAZ
Entrez ID		7533	7166
HPRD ID		00215	01846
Ensembl ID		ENSG00000128245
Uniprot IDs		Q04917 Q9H4N8	P17752
PDB IDs		2C63 2C74	1IN9 1MLW 3HF6 3HF8 3HFB
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Regulation Of Kinase Activity Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorus Metabolic Process System Development Multicellular Organismal Development Regulation Of Protein Phosphorylation Cellular Response To Stimulus Regulation Of Cell Death Regulation Of Protein Kinase Activity Regulation Of Cellular Process Response To Organic Substance Regulation Of Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Organelle Organization Cell Cycle Negative Regulation Of Cellular Metabolic Process Response To Organonitrogen Compound Apoptotic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Programmed Cell Death Response To Growth Factor	Intrinsic Apoptotic Signaling Pathway Platelet Activation Apoptotic Process Programmed Cell Death Positive Regulation Of Intracellular Transport Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Blood Coagulation Hemostasis Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Regulation Of Body Fluid Levels Wound Healing Regulation Of Establishment Of Protein Localization Cell Activation Regulation Of Mitochondrion Organization Response To Wounding Positive Regulation Of Transport Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Localization Glucocorticoid Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Membrane Organization Regulation Of Signal Transduction Regulation Of Ion Transmembrane Transporter Activity Regulation Of Protein Binding Regulation Of Transmembrane Transporter Activity Cell Maturation Regulation Of Signaling Synaptic Growth At Neuromuscular Junction Histone H3-T6 Phosphorylation Regulation Of Cellular Localization Negative Regulation Of Neuron Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Collateral Sprouting In Absence Of Injury Positive Regulation Of Cell Cycle Process Positive Regulation Of Signal Transduction Lipid Metabolic Process Immune Response Golgi Reassembly Lipid Catabolic Process Steroid Metabolic Process Defense Response Regulation Of Binding
Tagcloud ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	acaca crh deregressed dgat1 fasn fertility fp fy gh1 holstein lep lgb longevity mastitis mfge8 milk mscc paep pft piebaldism positives pp ppargc1a proofs py relatedness sires thrsp traits
Tagcloud (Difference) ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	acaca crh deregressed dgat1 fasn fertility fp fy gh1 holstein lep lgb longevity mastitis mfge8 milk mscc paep pft piebaldism positives pp ppargc1a proofs py relatedness sires thrsp traits
Tagcloud (Intersection) ?