YWHAH and KCNK15

Number of citations of the paper that reports this interaction (PubMedID 12433946)
40

Data Source:
HPRD (two hybrid, in vivo)

		YWHAH	KCNK15
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	potassium two pore domain channel subfamily K member 15
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Cerebellar Granule Cell To Purkinje Cell Synapse	Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Protein Heterodimerization Activity	Voltage-gated Monoatomic Ion Channel Activity Potassium Channel Activity Potassium Ion Leak Channel Activity
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Signal Transduction Intracellular Protein Localization Substantia Nigra Development Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Depolarization During Action Potential Presynaptic Modulation Of Chemical Synaptic Transmission	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Cellular Response To Acidic PH Potassium Ion Transmembrane Transport
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Phase 4 - resting membrane potential
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)	Obesity-related traits ( 23251661)
Interacting Genes		69 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ILF3 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCAM2 NCOA1 NCOA2 NCOA3 NEDD4L NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PCNT PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	7 interacting genes: SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		7533	60598
HPRD ID		00215	09564
Ensembl ID		ENSG00000128245	ENSG00000124249
Uniprot IDs		Q04917 Q9H4N8	Q9H427
PDB IDs		2C63 2C74 7NMZ
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Nuclear Receptor-mediated Signaling Pathway Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Biological Quality PAR Polarity Complex Regulation Of Intracellular Signal Transduction Regulation Of Transport Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Regulation Of Membrane Potential Regulation Of Apoptotic Process Regulation Of Vesicle-mediated Transport Cell Junction Organization Negative Regulation Of Apoptotic Process Phosphorylation Positive Regulation Of Metabolic Process Enzyme Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Lipid Cellular Response To Hormone Stimulus Hormone-mediated Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Anatomical Structure Morphogenesis Developmental Process Cytoskeleton Organization Cellular Response To Lipid Positive Regulation Of Intracellular Signal Transduction Regulation Of Secretion By Cell Regulation Of Phosphorus Metabolic Process Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Protein Serine/threonine Kinase Activity Synaptic Vesicle Priming Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein Kinase Activity	Phosphoserine Residue Binding Protein Sequestering Activity Protein Domain Specific Binding Protein Targeting Establishment Of Protein Localization Intracellular Protein Localization Identical Protein Binding Transmembrane Transporter Binding Focal Adhesion Extracellular Exosome Phosphoprotein Binding Protein Kinase C Inhibitor Activity Substantia Nigra Development Neural Nucleus Development Cadherin Binding Melanosome Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Nucleocytoplasmic Transport Insulin-like Growth Factor Receptor Binding Regulation Of Intracellular Protein Transport Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Immune System Process Signal Transduction Negative Regulation Of Immune Response Negative Regulation Of Protein Localization Regulation Of Protein Export From Nucleus Regulation Of Transport Regulation Of Intracellular Transport Protein Phosphatase Inhibitor Activity Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Intracellular Signaling Cassette Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Immune Response Cytosol TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of Protein Kinase Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Enzyme Binding Glucocorticoid Catabolic Process Negative Regulation Of Kinase Activity Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport TOR Signaling Regulation Of Protein Transport Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Innate Immune Response Positive Regulation Of Intracellular Protein Transport
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