PTH1R and TEKT4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PTH1R	TEKT4
Description		parathyroid hormone 1 receptor	tektin 4
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Receptor Complex	Nucleus Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Microtubule Cytoskeleton Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Skeletal System Development Ossification In Utero Embryonic Development Chondrocyte Differentiation Osteoblast Development Intracellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process	Cell Projection Organization Flagellated Sperm Motility Cilium Assembly Cilium Movement Involved In Cell Motility
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs		Abaloparatide Parathyroid hormone Teriparatide
Diseases		Eiken dysplasia Blomstrand syndrome; Blomstrand chondrodysplasia Primary failure of tooth eruption Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Birth weight ( 27680694 31043758) Hip circumference adjusted for BMI ( 34021172) Microalbuminuria ( 26631737) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 2 diabetes ( 30054458) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Parkinson's disease ( 34064523)
Interacting Genes		16 interacting genes: ARRB1 GNB1 GPANK1 GUCD1 HOXA1 MGAT5B MKRN3 NHERF1 NHERF2 PTH PTHLH SMARCC1 STK16 TEKT4 UBC YWHAH	105 interacting genes: ACBD4 AIRIM AKAP8L ALAS1 AMMECR1 ANKRD55 ARID5A ATG5 BCL6 BLZF1 BORCS8-MEF2B CFAP68 CTDSP1 DDIT4L EFHC2 EYA2 FAM220A GATA1 GPSM1 GRB10 GSE1 HCK HDAC6 HNRNPH1 HNRNPM HOXA1 HOXB5 HOXC8 IKZF3 INCA1 KPRP KRT15 KRT18 KRT34 KRT35 KRT75 KRT86 KRTAP11-1 KRTAP13-1 KRTAP13-3 KRTAP19-1 KRTAP19-2 KRTAP19-6 KRTAP26-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LASP1 LMCD1 LNX1 MAGEA4 MIIP MORN3 MYOZ3 NANOS3 NFKBID NR5A1 PCSK5 PHF11 PKP2 PLAGL2 POLDIP3 PPP1R13B PRDM14 PRDM6 PROP1 PSMA1 PTH1R RAMAC RARA RBM48 RECK RFX6 RUSC1 SAXO4 SCN5A SLC25A6 SMAD3 SOCS4 SPATA8 SPATC1L SPG21 SPMIP6 SUV39H1 TADA2A TEKT1 TFAP4 TOX2 TRIB3 TRIP6 TSPAN4 UBASH3A USP2 VGLL1 ZFP90 ZIM2 ZMYND12 ZNF20 ZNF417 ZNF426 ZNF474 ZNF552 ZNF581 ZNF655 ZNF688
Entrez ID		5745	150483
HPRD ID		01347	14518
Ensembl ID		ENSG00000160801	ENSG00000163060
Uniprot IDs		Q03431 Q0VGD7	A0A384MEB7 Q8WW24
PDB IDs		1BL1 3C4M 3H3G 3L2J 4Z8J 5EMB 6NBF 6NBH 6NBI 7UZO 7UZP 7VVJ 7VVK 7VVL 7VVM 7VVN 7VVO 7Y35 7Y36 8BIA 8BJ0 8D51 8D52 8FLQ 8FLR 8FLS 8FLT 8FLU 8GW8 8HA0 8HAF 8HAO 8JR9 9JR2 9JR3	7UNG
Enriched GO Terms of Interacting Partners?		Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Peptide Hormone Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Insulin-like Growth Factor Receptor Binding Phosphate Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Negative Regulation Of Chondrocyte Differentiation CAMP Metabolic Process Negative Regulation Of Cartilage Development Protein-membrane Adaptor Activity Sensory Perception Molecular Adaptor Activity Semicircular Canal Formation Cyclic Purine Nucleotide Metabolic Process Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Glucocorticoid Catabolic Process Renal Phosphate Ion Absorption Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Regulation Of Chondrocyte Differentiation Phosphatase Binding Bone Mineralization Angiotensin Receptor Binding Abducens Nerve Formation Optokinetic Behavior Regulation Of Sodium Ion Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding	Intermediate Filament Protein Binding Keratin Filament Nucleus Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Axonemal A Tubule Inner Sheath Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intermediate Filament Organization Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding DNA-binding Transcription Factor Activity Chromatin DNA Binding Structural Molecule Activity Histone Deacetylase Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Structural Constituent Of Skin Epidermis Regulation Of Nucleobase-containing Compound Metabolic Process Flagellated Sperm Motility Sperm Motility DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cilium-dependent Cell Motility Sperm Flagellum Regulation Of Primary Metabolic Process Cilium Movement Involved In Cell Motility Nucleoplasm Sequence-specific Double-stranded DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Sequence-specific DNA Binding Cilium Movement Negative Regulation Of RNA Metabolic Process Keratinization Erythrocyte Development
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