YWHAH and ARHGEF28

Number of citations of the paper that reports this interaction (PMID 11533041)
21

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		YWHAH	ARHGEF28
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta	Rho guanine nucleotide exchange factor (GEF) 28
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Intercalated Disc Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Cytosol Plasma Membrane
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Ion Channel Binding Protein Heterodimerization Activity	RNA Binding Rho Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Apoptotic Process Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity	Axon Guidance Central Nervous System Neuron Axonogenesis Positive Regulation Of Rho GTPase Activity Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Neurofilament Cytoskeleton Organization
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis	EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ABL1 ARHGEF28 BAD BCR BRAF CDC25B CDC25C CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 ING1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NR3C1 NRIP1 PARD3 PARD6A PARD6B PARK2 PDPK1 PRKCI PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	4 interactors: MAPK8IP1 RHOA YWHAE YWHAH
Entrez ID		7533	64283
HPRD ID		00215	15244
Ensembl ID		ENSG00000128245	ENSG00000214944
Uniprot IDs		Q04917 Q9H4N8	Q8N1W1
PDB IDs		2C63 2C74
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Regulation Of Kinase Activity Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorus Metabolic Process System Development Multicellular Organismal Development Regulation Of Protein Phosphorylation Cellular Response To Stimulus Regulation Of Cell Death Regulation Of Protein Kinase Activity Regulation Of Cellular Process Response To Organic Substance Regulation Of Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Organelle Organization Cell Cycle Negative Regulation Of Cellular Metabolic Process Response To Organonitrogen Compound Apoptotic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Programmed Cell Death Response To Growth Factor	Substantia Nigra Development Neural Nucleus Development Midbrain Development Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Intracellular Signal Transduction Action Potential Regulation Of Mitochondrion Organization Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Brain Development Regulation Of Protein Localization Negative Regulation Of Neuron Projection Development Head Development Glucocorticoid Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Cell Projection Organization Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Organelle Organization Central Nervous System Development Regulation Of Signaling Negative Regulation Of Peptidyl-serine Dephosphorylation Regulation Of Heart Rate By Hormone Regulation Of Cellular Localization Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Differentiation Positive Regulation Of Apoptotic Signaling Pathway Skeletal Muscle Satellite Cell Migration Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Membrane Potential Negative Regulation Of Neurogenesis Regulation Of Apoptotic Process Negative Regulation Of Protein Dephosphorylation Apolipoprotein A-I-mediated Signaling Pathway JUN Phosphorylation Cleavage Furrow Formation Regulation Of Cell Death Generation Of Neurons Negative Regulation Of Cell Development Apoptotic Signaling Pathway Neurogenesis
Tagcloud ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	als approx comprehensive copy destabilizing encodes fals familial fus generate guanine heterozygous homozygosity inclusions kb motor mtsod1 neuron nfl premature rgnef rho sals spinal sporadic taqman tls truncated warranted
Tagcloud (Difference) ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	als approx comprehensive copy destabilizing encodes fals familial fus generate guanine heterozygous homozygosity inclusions kb motor mtsod1 neuron nfl premature rgnef rho sals spinal sporadic taqman tls truncated warranted
Tagcloud (Intersection) ?