YWHAH and ARHGEF28

Number of citations of the paper that reports this interaction (PubMedID 11533041)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		YWHAH	ARHGEF28
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	Rho guanine nucleotide exchange factor 28
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Cerebellar Granule Cell To Purkinje Cell Synapse	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Protein Heterodimerization Activity	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Signal Transduction Intracellular Protein Localization Substantia Nigra Development Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Depolarization During Action Potential Presynaptic Modulation Of Chemical Synaptic Transmission	Cell Morphogenesis Central Nervous System Neuron Axonogenesis Cell Differentiation Regulation Of Rho Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Neurofilament Cytoskeleton Organization
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	EPHB-mediated forward signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)	Age-related hearing impairment ( 34108613) Chin dimples ( 27182965) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) HDL cholesterol ( 30275531) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hodgkin's lymphoma ( 34216518) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Vaginal microbiome composition (Shannon diversity index) ( 32723796) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		69 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ILF3 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCAM2 NCOA1 NCOA2 NCOA3 NEDD4L NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PCNT PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	8 interacting genes: AKT1 CTAG1A CTAG1B MAPK8IP1 RHOA TARDBP YWHAE YWHAH
Entrez ID		7533	64283
HPRD ID		00215	15244
Ensembl ID		ENSG00000128245	ENSG00000214944
Uniprot IDs		Q04917 Q9H4N8	Q8N1W1
PDB IDs		2C63 2C74 7NMZ	6BC0 6BC1
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Nuclear Receptor-mediated Signaling Pathway Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Biological Quality PAR Polarity Complex Regulation Of Intracellular Signal Transduction Regulation Of Transport Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Regulation Of Membrane Potential Regulation Of Apoptotic Process Regulation Of Vesicle-mediated Transport Cell Junction Organization Negative Regulation Of Apoptotic Process Phosphorylation Positive Regulation Of Metabolic Process Enzyme Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Lipid Cellular Response To Hormone Stimulus Hormone-mediated Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Anatomical Structure Morphogenesis Developmental Process Cytoskeleton Organization Cellular Response To Lipid Positive Regulation Of Intracellular Signal Transduction Regulation Of Secretion By Cell Regulation Of Phosphorus Metabolic Process Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Protein Serine/threonine Kinase Activity Synaptic Vesicle Priming Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein Kinase Activity	Intracellular Receptor Signaling Pathway Substantia Nigra Development Neural Nucleus Development Positive Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Protein Phosphorylation Protein Localization To Endoplasmic Reticulum Regulation Of Phosphorylation Identical Protein Binding TRNA Threonylcarbamoyladenosine Metabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway TRNA Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Modification Process Regulation Of Toll-like Receptor Signaling Pathway Protein K11-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Sodium Ion Transport Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Migration Regulation Of Metal Ion Transport Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of TRNA Methylation Golgi To Plasma Membrane Transport Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Positive Regulation Of Nucleocytoplasmic Transport Glucocorticoid Catabolic Process Dentate Gyrus Mossy Fiber Nuclear Inner Membrane Organization Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Regulation Of T Cell Activation RNA Stabilization Enzyme Binding Negative Regulation Of RNA Catabolic Process Positive Regulation Of Organelle Assembly Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Protein Kinase Binding Response To Heat Cytoplasm Regulation Of Neuron Projection Development Negative Regulation Of Protein Localization To Lysosome Endothelial Cell Migration
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