YWHAH and EXO1

Number of citations of the paper that reports this interaction (PMID 22222486)
3

Data Source:
BioGRID (two hybrid, pull down)

		YWHAH	EXO1
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta	exonuclease 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Intercalated Disc Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Ion Channel Binding Protein Heterodimerization Activity	DNA Binding RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-3' Exodeoxyribonuclease Activity Structure-specific DNA Binding Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' Exodeoxyribonuclease Activity
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Apoptotic Process Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity	DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Repair Mismatch Repair DNA Recombination Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS			Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		61 interactors: ABL1 ARHGEF28 BAD BCR BRAF CDC25B CDC25C CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 ING1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NR3C1 NRIP1 PARD3 PARD6A PARD6B PARK2 PDPK1 PRKCI PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	15 interactors: ATM KPNA4 KPNB1 MLH1 MSH2 MSH3 PCNA PMS2 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		7533	9156
HPRD ID		00215	06932
Ensembl ID		ENSG00000128245	ENSG00000174371
Uniprot IDs		Q04917 Q9H4N8	Q9UQ84
PDB IDs		2C63 2C74	3QE9 3QEA 3QEB
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Regulation Of Kinase Activity Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorus Metabolic Process System Development Multicellular Organismal Development Regulation Of Protein Phosphorylation Cellular Response To Stimulus Regulation Of Cell Death Regulation Of Protein Kinase Activity Regulation Of Cellular Process Response To Organic Substance Regulation Of Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Organelle Organization Cell Cycle Negative Regulation Of Cellular Metabolic Process Response To Organonitrogen Compound Apoptotic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Programmed Cell Death Response To Growth Factor	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Mismatch Repair Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Organelle Organization Protein Targeting DNA Recombination Regulation Of Intracellular Transport Somatic Recombination Of Immunoglobulin Gene Segments Cellular Response To Stimulus Somatic Diversification Of Immunoglobulins Intracellular Signal Transduction Intracellular Protein Transport Regulation Of Apoptotic Process Immunoglobulin Production Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Stimulus Positive Regulation Of Transport Regulation Of Protein Localization System Development Negative Regulation Of DNA Recombination Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Signal Transduction Cellular Response To DNA Damage Stimulus Membrane Organization Response To Stress Cellular Protein Localization Meiosis I Regulation Of Cellular Component Organization Protein Transport Establishment Of Localization In Cell DNA Repair Establishment Of Protein Localization
Tagcloud ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	break dephospho dsb exonuclease forks helicase hu hydroxyurea hypermorphs mec1 mimicking mispaired mlh1 mmr mms msh2 nucleases pol32 pol32delta polymerases rad2 rad53 s372 s567 s587 s692 sgs1 stalled zeta
Tagcloud (Difference) ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	break dephospho dsb exonuclease forks helicase hu hydroxyurea hypermorphs mec1 mimicking mispaired mlh1 mmr mms msh2 nucleases pol32 pol32delta polymerases rad2 rad53 s372 s567 s587 s692 sgs1 stalled zeta
Tagcloud (Intersection) ?