YWHAH and ILF3

Number of citations of the paper that reports this interaction (PubMedID 35013429)
55

Data Source:
BioGRID (unspecified method)

		YWHAH	ILF3
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	interleukin enhancer binding factor 3
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Cerebellar Granule Cell To Purkinje Cell Synapse	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Ribonucleoprotein Complex
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Protein Heterodimerization Activity	Virus Receptor Activity DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Signal Transduction Intracellular Protein Localization Substantia Nigra Development Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Depolarization During Action Potential Presynaptic Modulation Of Chemical Synaptic Transmission	Protein Phosphorylation Negative Regulation Of Translation Negative Regulation Of Viral Genome Replication Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell Defense Response To Virus Spliceosome-depend Formation Of Circular RNA
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription PKR-mediated signaling
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)	Bipolar disorder ( 31043756) Chronotype ( 30696823) Height ( 25282103 25429064) Obesity-related traits ( 23251661) Psoriasis ( 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 30423114) Systemic lupus erythematosus ( 28714469)
Interacting Genes		69 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ILF3 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCAM2 NCOA1 NCOA2 NCOA3 NEDD4L NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PCNT PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	44 interacting genes: CEBPA DHX9 DUX4 EIF2AK2 EP300 ERBB2 ERG ESR1 FUS GDF9 HNRNPH2 IL7R IRF3 IRF9 KRTAP4-12 LINC00624 LNX1 MAGEA11 MAPK1 MDFI NDRG1 OGT PLSCR1 PRMT1 PRMT5 PSMA3 PTEN RBM5 RBPMS SF1 SF3B4 SMN1 SPOP TRIM55 TRIM63 TRIP6 UBC USP7 VPS37C XAB2 XPO5 YWHAH ZNF346 ZNF830
Entrez ID		7533	3609
HPRD ID		00215	04420
Ensembl ID		ENSG00000128245	ENSG00000129351
Uniprot IDs		Q04917 Q9H4N8	Q12906
PDB IDs		2C63 2C74 7NMZ	2L33 3P1X 7RJM 7RJQ
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Nuclear Receptor-mediated Signaling Pathway Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Biological Quality PAR Polarity Complex Regulation Of Intracellular Signal Transduction Regulation Of Transport Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Regulation Of Membrane Potential Regulation Of Apoptotic Process Regulation Of Vesicle-mediated Transport Cell Junction Organization Negative Regulation Of Apoptotic Process Phosphorylation Positive Regulation Of Metabolic Process Enzyme Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Lipid Cellular Response To Hormone Stimulus Hormone-mediated Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Anatomical Structure Morphogenesis Developmental Process Cytoskeleton Organization Cellular Response To Lipid Positive Regulation Of Intracellular Signal Transduction Regulation Of Secretion By Cell Regulation Of Phosphorus Metabolic Process Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Protein Serine/threonine Kinase Activity Synaptic Vesicle Priming Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein Kinase Activity	Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding RNA Splicing Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein-RNA Complex Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Cytosol Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Cytoplasm Positive Regulation Of RNA Metabolic Process RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex Assembly Protein Modification Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleic Acid Binding Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions DNA-templated Transcription Termination RNA Binding Nucleic Acid Metabolic Process TORC1 Signaling Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Population Proliferation Macromolecule Biosynthetic Process Cellular Component Assembly RNA Processing Cellular Response To Nutrient Levels Protein-containing Complex Assembly RISC Complex Binding Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation TOR Signaling Chromatin DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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