PTH1R and SLC9A3R2

Number of citations of the paper that reports this interaction (PMID 12075354)
61

Data Source:
HPRD (in vivo)

		PTH1R	SLC9A3R2
Gene Name		parathyroid hormone 1 receptor	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Parathyroid Hormone Receptor Activity Protein Binding Peptide Hormone Binding Protein Self-association	Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding
	Biological Process	Skeletal System Development Chondrocyte Differentiation Osteoblast Development G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process	Protein Complex Assembly Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ARRB1 GNB1 PTH PTHLH SLC9A3R1 SLC9A3R2 UBC YWHAH	35 interactors: ABCC4 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDPK1 PDZK1 PIK3CA PLCB3 PODXL PRKACA PTEN PTH1R RDX SGK1 SGK3 SIAH1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAZ TBC1D10A WWTR1
Entrez ID		5745	9351
HPRD ID		01347	05946
Ensembl ID		ENSG00000160801	ENSG00000065054
Uniprot IDs		Q03431 Q0VGD7	Q15599
PDB IDs		1BL1 1ET2 1ET3 3C4M 3H3G 3KJ5 3L2J	2D11 2HE4 2OCS
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Programmed Cell Death Cell Death Death Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Signal Transduction Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Phosphorus Metabolic Process Dopamine Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Cellular Biosynthetic Process CAMP Metabolic Process Chemical Homeostasis Cell Surface Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Signal Transduction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Regulation Of Sodium Ion Transport Positive Regulation Of CAMP Metabolic Process Negative Regulation Of Signal Transduction Signaling Cyclic Nucleotide Metabolic Process Cell Communication G-protein Coupled Receptor Signaling Pathway Renal Phosphate Ion Absorption Glucocorticoid Catabolic Process Nipple Sheath Formation Mammary Gland Bud Elongation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Ion Homeostasis Negative Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of CAMP Biosynthetic Process Phototransduction Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of CAMP Metabolic Process Negative Regulation Of Protein Ubiquitination Detection Of Light Stimulus Positive Regulation Of Transcription, DNA-templated Cellular Chemical Homeostasis Cellular Response To Oxygen Levels	Regulation Of Protein Kinase Activity Ion Homeostasis Transmembrane Transport Regulation Of Kinase Activity Regulation Of Ion Transport Positive Regulation Of Ion Transport Regulation Of Protein Phosphorylation Homeostatic Process Positive Regulation Of Transport Ion Transport Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Ion Transmembrane Transport Cellular Cation Homeostasis Organic Anion Transport Cellular Ion Homeostasis Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Positive Regulation Of Protein Kinase Activity Blood Circulation Positive Regulation Of Cellular Protein Metabolic Process Anion Transport Platelet Activation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Transport Positive Regulation Of Protein Phosphorylation Sodium-independent Organic Anion Transport Carnitine Transport Cellular Chemical Homeostasis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Monocarboxylic Acid Transport Sperm Capacitation Anion Transmembrane Transport Regulation Of Cellular Component Organization Sodium Ion Transport Inorganic Anion Transport Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Quaternary Ammonium Group Transport Positive Regulation Of Cytosolic Calcium Ion Concentration
Tagcloud ?		293a arrestin arrestin1 b2r bona cargo cargoes cognate colocalization construction cytofluorometric egfp endosomal fide gpcrs hek internalization internalize lysate maximakinin mk preproinsulin rab5 rab7 recipient secretable transporting verify
Tagcloud (Difference) ?		293a arrestin arrestin1 b2r bona cargo cargoes cognate colocalization construction cytofluorometric egfp endosomal fide gpcrs hek internalization internalize lysate maximakinin mk preproinsulin rab5 rab7 recipient secretable transporting verify
Tagcloud (Intersection) ?