YWHAH and NEK1

Number of citations of the paper that reports this interaction (PMID 14690447)
15

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		YWHAH	NEK1
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta	NIMA-related kinase 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Intercalated Disc Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Pericentriolar Material Nucleus Cytoplasm Centrosome
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Ion Channel Binding Protein Heterodimerization Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Apoptotic Process Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity	MAPK Cascade Activation Of MAPK Activity Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Cilium Assembly Cell Division
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ABL1 ARHGEF28 BAD BCR BRAF CDC25B CDC25C CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 ING1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NR3C1 NRIP1 PARD3 PARD6A PARD6B PARK2 PDPK1 PRKCI PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	13 interactors: ATRX CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 KIF3A MRE11A PPP2R5A TP53BP1 TSC2 YWHAH ZNF350
Entrez ID		7533	4750
HPRD ID		00215	06847
Ensembl ID		ENSG00000128245	ENSG00000137601
Uniprot IDs		Q04917 Q9H4N8	Q5JXL9 Q96PY6
PDB IDs		2C63 2C74	4APC 4B9D
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Regulation Of Kinase Activity Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorus Metabolic Process System Development Multicellular Organismal Development Regulation Of Protein Phosphorylation Cellular Response To Stimulus Regulation Of Cell Death Regulation Of Protein Kinase Activity Regulation Of Cellular Process Response To Organic Substance Regulation Of Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Organelle Organization Cell Cycle Negative Regulation Of Cellular Metabolic Process Response To Organonitrogen Compound Apoptotic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Programmed Cell Death Response To Growth Factor	Response To Stimulus Regulation Of Cellular Component Organization Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Nervous System Development Regulation Of Cellular Process DNA Recombination Glucocorticoid Catabolic Process Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Regulation Of Dendrite Morphogenesis DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Generation Of Neurons DNA Modification Neurogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Dendrite Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Lipid Kinase Activity Cellular Response To Hydroxyurea DNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Stem Cell Homeostasis Regulation Of DNA Replication Signal Transduction Neuron Differentiation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Nuclear Cell Cycle DNA Replication Protein Transport Into Plasma Membrane Raft Cell Projection Organization Double-strand Break Repair System Development Regulation Of Mitotic Recombination Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Plasma Membrane Raft Regulation Of Transcription, DNA-templated Nuclear MRNA Surveillance DNA Repair Chemotaxis Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Cell Communication Positive Regulation Of Transcription, DNA-templated Regulation Of Endocytosis Regulation Of RNA Metabolic Process Cullin Deneddylation
Tagcloud ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	axin cdk1 crb3 dock7 dsh ezrin fip200 gadd34 gsk3 hamartin herc1 hscp immunoprecipitate melted merlin moesin nade p27kip1 p75ntr pam patj pc1 pp2ac rabaptin radixin rheb rsk1 tbc7 tuberin
Tagcloud (Difference) ?		3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization	axin cdk1 crb3 dock7 dsh ezrin fip200 gadd34 gsk3 hamartin herc1 hscp immunoprecipitate melted merlin moesin nade p27kip1 p75ntr pam patj pc1 pp2ac rabaptin radixin rheb rsk1 tbc7 tuberin
Tagcloud (Intersection) ?