PTH1R and YWHAH

Number of citations of the paper that reports this interaction (PMID 12595070)
6

Data Source:
HPRD (in vitro, in vivo)

		PTH1R	YWHAH
Gene Name		parathyroid hormone 1 receptor	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome	Cytoplasm Cytosol Plasma Membrane Intercalated Disc Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Parathyroid Hormone Receptor Activity Protein Binding Peptide Hormone Binding Protein Self-association	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Ion Channel Binding Protein Heterodimerization Activity
	Biological Process	Skeletal System Development Chondrocyte Differentiation Osteoblast Development G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Apoptotic Process Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ARRB1 GNB1 PTH PTHLH SLC9A3R1 SLC9A3R2 UBC YWHAH	61 interactors: ABL1 ARHGEF28 BAD BCR BRAF CDC25B CDC25C CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 ING1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NR3C1 NRIP1 PARD3 PARD6A PARD6B PARK2 PDPK1 PRKCI PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36
Entrez ID		5745	7533
HPRD ID		01347	00215
Ensembl ID		ENSG00000160801	ENSG00000128245
Uniprot IDs		Q03431 Q0VGD7	Q04917 Q9H4N8
PDB IDs		1BL1 1ET2 1ET3 3C4M 3H3G 3KJ5 3L2J	2C63 2C74
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Programmed Cell Death Cell Death Death Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Signal Transduction Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Phosphorus Metabolic Process Dopamine Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Cellular Biosynthetic Process CAMP Metabolic Process Chemical Homeostasis Cell Surface Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Signal Transduction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Regulation Of Sodium Ion Transport Positive Regulation Of CAMP Metabolic Process Negative Regulation Of Signal Transduction Signaling Cyclic Nucleotide Metabolic Process Cell Communication G-protein Coupled Receptor Signaling Pathway Renal Phosphate Ion Absorption Glucocorticoid Catabolic Process Nipple Sheath Formation Mammary Gland Bud Elongation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Ion Homeostasis Negative Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of CAMP Biosynthetic Process Phototransduction Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of CAMP Metabolic Process Negative Regulation Of Protein Ubiquitination Detection Of Light Stimulus Positive Regulation Of Transcription, DNA-templated Cellular Chemical Homeostasis Cellular Response To Oxygen Levels	Signaling Cell Communication Regulation Of Kinase Activity Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorus Metabolic Process System Development Multicellular Organismal Development Regulation Of Protein Phosphorylation Cellular Response To Stimulus Regulation Of Cell Death Regulation Of Protein Kinase Activity Regulation Of Cellular Process Response To Organic Substance Regulation Of Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Organelle Organization Cell Cycle Negative Regulation Of Cellular Metabolic Process Response To Organonitrogen Compound Apoptotic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Programmed Cell Death Response To Growth Factor
Tagcloud ?		293a arrestin arrestin1 b2r bona cargo cargoes cognate colocalization construction cytofluorometric egfp endosomal fide gpcrs hek internalization internalize lysate maximakinin mk preproinsulin rab5 rab7 recipient secretable transporting verify	3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization
Tagcloud (Difference) ?		293a arrestin arrestin1 b2r bona cargo cargoes cognate colocalization construction cytofluorometric egfp endosomal fide gpcrs hek internalization internalize lysate maximakinin mk preproinsulin rab5 rab7 recipient secretable transporting verify	3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization
Tagcloud (Intersection) ?