YWHAH and REM1

Number of citations of the paper that reports this interaction (PubMedID 10441394)
0

Data Source:
HPRD (in vitro, in vivo)

		YWHAH	REM1
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	RRAD and GEM like GTPase 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Cerebellar Granule Cell To Purkinje Cell Synapse	Plasma Membrane T-tubule I Band
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Protein Heterodimerization Activity	Nucleotide Binding GTPase Activity Calcium Channel Regulator Activity Calmodulin Binding GTP Binding Transmembrane Transporter Binding
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Signal Transduction Intracellular Protein Localization Substantia Nigra Development Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Depolarization During Action Potential Presynaptic Modulation Of Chemical Synaptic Transmission	Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)
Interacting Genes		69 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ILF3 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCAM2 NCOA1 NCOA2 NCOA3 NEDD4L NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PCNT PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	7 interacting genes: CACNB1 CACNB2 CACNB4 YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		7533	28954
HPRD ID		00215	15237
Ensembl ID		ENSG00000128245	ENSG00000088320
Uniprot IDs		Q04917 Q9H4N8	O75628
PDB IDs		2C63 2C74 7NMZ	2NZJ
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Nuclear Receptor-mediated Signaling Pathway Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Biological Quality PAR Polarity Complex Regulation Of Intracellular Signal Transduction Regulation Of Transport Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Regulation Of Membrane Potential Regulation Of Apoptotic Process Regulation Of Vesicle-mediated Transport Cell Junction Organization Negative Regulation Of Apoptotic Process Phosphorylation Positive Regulation Of Metabolic Process Enzyme Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Lipid Cellular Response To Hormone Stimulus Hormone-mediated Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Anatomical Structure Morphogenesis Developmental Process Cytoskeleton Organization Cellular Response To Lipid Positive Regulation Of Intracellular Signal Transduction Regulation Of Secretion By Cell Regulation Of Phosphorus Metabolic Process Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Protein Serine/threonine Kinase Activity Synaptic Vesicle Priming Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein Kinase Activity	Voltage-gated Calcium Channel Complex Voltage-gated Calcium Channel Activity Regulation Of Monoatomic Ion Transport Transmembrane Transporter Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Substantia Nigra Development Calcium Channel Regulator Activity Protein Domain Specific Binding Regulation Of Cytosolic Calcium Ion Concentration Neural Nucleus Development Phosphoserine Residue Binding Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Transport Calcium Channel Activity Regulation Of Metal Ion Transport L-type Voltage-gated Calcium Channel Complex High Voltage-gated Calcium Channel Activity Monoatomic Ion Channel Complex Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Membrane Potential Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential Intracellular Calcium Ion Homeostasis Calcium Ion Transmembrane Transport Protein Targeting Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Presynapse Calcium Ion Transport Neuromuscular Junction Development Regulation Of Heart Rate By Cardiac Conduction Regulation Of Monoatomic Cation Transmembrane Transport Protein Sequestering Activity Cardiac Conduction Positive Regulation Of Muscle Contraction Chemical Synaptic Transmission Intracellular Protein Localization Membrane Depolarization Trans-synaptic Signaling Synapse Synaptic Signaling Neuron Cellular Homeostasis Negative Regulation Of Monoatomic Ion Transmembrane Transport Glucocorticoid Catabolic Process Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Focal Adhesion Protein Phosphatase Binding
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