MSH3 and TSC22D2

Number of citations of the paper that reports this interaction (PubMedID 27337956)
0

Data Source:
BioGRID (two hybrid)

		MSH3	TSC22D2
Description		mutS homolog 3	TSC22 domain family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane MutSbeta Complex
	Molecular Function	Nucleotide Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity ATP-dependent DNA Damage Sensor Activity	Protein Binding
	Biological Process	DNA Repair Mismatch Repair Mitotic Recombination DNA Damage Response Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Cell Cycle
Pathways		Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2
Drugs
Diseases		Colorectal cancer
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Huntington's disease progression ( 28642124) Idiopathic downbeat nystagmus ( 32157568) Subcortical volume (MOSTest) ( 32665545)	A body shape index ( 34021172) Adiponectin levels ( 22479202) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29235454) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Moyamoya disease ( 29273593) PR interval ( 32439900) Pulse pressure ( 27841878) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32154731 32203549) Type 2 diabetes ( 30297969 30054458) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		14 interacting genes: BARD1 BRCA1 ERG EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 SUMO2 TSC22D2 XPA	43 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 DNAAF11 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL MED13 MPDZ MSH3 MTIF2 NGRN OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 USP7 WNK3 ZMYM2 ZNF143 ZNF251
Entrez ID		4437	9819
HPRD ID		02931	11101
Ensembl ID		ENSG00000113318	ENSG00000196428
Uniprot IDs		P20585	B4DN36 O75157
PDB IDs		3THW 3THX 3THY 3THZ 8OLX 8OM5 8OM9 8OMA 8OMO 8OMQ 8R7C 8R7E 8R7V 8RZ7 8RZ8 8RZ9
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Radiation Response To Radiation Response To Ionizing Radiation Cellular Response To Stress Damaged DNA Binding Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle Checkpoint Clamp Complex Mismatch Repair DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition Nucleic Acid Metabolic Process Postreplication Repair DNA Recombination Negative Regulation Of Cell Cycle Process Nucleoplasm Response To Stress Signal Transduction In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes DNA Strand Resection Involved In Replication Fork Processing Somatic Diversification Of Immune Receptors Via Somatic Mutation Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Dinucleotide Insertion Or Deletion Binding Somatic Recombination Of Immunoglobulin Gene Segments BRCA1-B Complex Homologous Recombination Guanine/thymine Mispair Binding Apoptotic Signaling Pathway Somatic Diversification Of Immunoglobulins Chromosome Organization Response To UV Somatic Cell DNA Recombination Regulation Of Cell Cycle	Transporter Activator Activity Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transport Negative Regulation Of Pancreatic Juice Secretion Regulation Of Potassium Ion Import Regulation Of Sodium Ion Transmembrane Transport Proteasome Core Complex, Alpha-subunit Complex
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