MSH3

Name	mutS homolog 3
Structure
Interactors	14 interactors: BARD1 BRCA1 ERG EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 SUMO2 TSC22D2 XPA
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane MutSbeta Complex
	Molecular Function	Nucleotide Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	DNA Repair Mismatch Repair Mitotic Recombination DNA Damage Response Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination
Pathways	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2
Diseases	Colorectal cancer
GWAS	Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Huntington's disease progression ( 28642124 ) Idiopathic downbeat nystagmus ( 32157568 ) Subcortical volume (MOSTest) ( 32665545 )
Entrez ID	4437
HPRD ID	02931
Ensembl ID	ENSG00000113318
Uniprot IDs	P20585
PDB IDs	3THW 3THX 3THY 3THZ 8OLX 8OM5 8OM9 8OMA 8OMO 8OMQ 8R7C 8R7E 8R7V 8RZ7 8RZ8 8RZ9
GO Terms Enriched among Interactors ?	DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Radiation Response To Radiation Response To Ionizing Radiation Cellular Response To Stress Damaged DNA Binding Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle Checkpoint Clamp Complex Mismatch Repair DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition Nucleic Acid Metabolic Process Postreplication Repair DNA Recombination Negative Regulation Of Cell Cycle Process Nucleoplasm Response To Stress Signal Transduction In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes DNA Strand Resection Involved In Replication Fork Processing Somatic Diversification Of Immune Receptors Via Somatic Mutation Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Dinucleotide Insertion Or Deletion Binding Somatic Recombination Of Immunoglobulin Gene Segments BRCA1-B Complex Homologous Recombination Guanine/thymine Mispair Binding Apoptotic Signaling Pathway Somatic Diversification Of Immunoglobulins Chromosome Organization Response To UV Somatic Cell DNA Recombination Regulation Of Cell Cycle