MSH3 and XPA

Number of citations of the paper that reports this interaction (PMID 19468048)
25

Data Source:
BioGRID (pull down)

		MSH3	XPA
Gene Name		mutS homolog 3	xeroderma pigmentosum, complementation group A
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Membrane MutSbeta Complex	Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Golgi Apparatus Intercellular Bridge
	Molecular Function	Y-form DNA Binding Heteroduplex DNA Loop Binding Double-strand/single-strand DNA Junction Binding Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Centromeric DNA Binding Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Meiotic Mismatch Repair DNA Repair Mismatch Repair Reciprocal Meiotic Recombination Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Multicellular Organism Growth
Pathways		Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch Repair	Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		12 interactors: BARD1 BRCA1 EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 RPA4 XPA	20 interactors: ATM ATR DDB1 DDB2 ERCC1 ERCC6 GPN1 GTF2E2 GTF2H1 HERC2 MSH2 MSH3 NDEL1 PRKDC RASSF1 RPA1 RPA2 RPA4 TRIM27 XAB2
Entrez ID		4437	7507
HPRD ID		02931	02045
Ensembl ID		ENSG00000113318	ENSG00000136936
Uniprot IDs		A1L480 P20585	P23025
PDB IDs		3THW 3THX 3THY 3THZ	1D4U 1XPA 2JNW
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress DNA Recombination Cell Cycle DNA Damage Checkpoint Cell Cycle Process Cell Cycle Checkpoint DNA Replication Response To Ionizing Radiation Response To Stress Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Radiation Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Postreplication Repair Isotype Switching Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments DNA Catabolic Process DNA Catabolic Process, Exonucleolytic Double-strand Break Repair Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Nitrogen Compound Metabolic Process B Cell Activation Involved In Immune Response Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Meiotic Cell Cycle Cellular Response To Ionizing Radiation Immunoglobulin Production Protein K6-linked Ubiquitination Response To Abiotic Stimulus Cellular Response To Stimulus Intra-S DNA Damage Checkpoint Mitotic Cell Cycle Process Nucleotide-excision Repair Negative Regulation Of DNA Metabolic Process Apoptotic Signaling Pathway Mitotic Cell Cycle Response To UV Cellular Metabolic Process	DNA Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair, DNA Damage Removal DNA Recombination Transcription-coupled Nucleotide-excision Repair Response To Stress Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Response To UV Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Response To Radiation DNA Catabolic Process DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Cell Cycle Process Response To Abiotic Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cell Cycle Checkpoint Cell Cycle Chromosome Organization Aromatic Compound Catabolic Process Pyrimidine Dimer Repair Response To Gamma Radiation Mismatch Repair Cellular Response To Stimulus Immunoglobulin Production Cellular Macromolecule Catabolic Process Response To Light Stimulus Cellular Response To Heat Telomere Maintenance Mitotic Cell Cycle Process Reproduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Organelle Organization Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Response To X-ray Mitotic Recombination
Tagcloud ?		addressed aom apc apex1 azoxymethane carcinogenesis colorectal crc dextran dss epi experimentally expressions mgmt mismatch mlh1 mlh3 mmr pilot pms1 pms2 precancerous prerequisite rectum sacrificed sequential sigmoid sulphate suppressor
Tagcloud (Difference) ?		addressed aom apc apex1 azoxymethane carcinogenesis colorectal crc dextran dss epi experimentally expressions mgmt mismatch mlh1 mlh3 mmr pilot pms1 pms2 precancerous prerequisite rectum sacrificed sequential sigmoid sulphate suppressor
Tagcloud (Intersection) ?