MSH3 and RAD9A

Number of citations: 89 (PubMedID 20188637)
Data Source: BioGRID (far western blotting)

		MSH3	RAD9A
Name		mutS homolog 3	RAD9 checkpoint clamp component A
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane MutSbeta Complex	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex
	Molecular Function	Nucleotide Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity ATP-dependent DNA Damage Sensor Activity	Nuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding
	Biological Process	DNA Repair Mismatch Repair Mitotic Recombination DNA Damage Response Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Diseases		Colorectal cancer	None
GWAS		Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Huntington's disease progression ( 28642124 ) Idiopathic downbeat nystagmus ( 32157568 ) Subcortical volume (MOSTest) ( 32665545 )	Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 )
Interacting Genes		14 interacting genes: BARD1 BRCA1 ERG EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 SUMO2 TSC22D2 XPA	39 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CDK1 CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN
Entrez ID		4437	5883
HPRD ID		02931	04788
Ensembl ID		ENSG00000113318	ENSG00000172613
Uniprot IDs		P20585	Q99638
PDB IDs		3THW 3THX 3THY 3THZ 8OLX 8OM5 8OM9 8OMA 8OMO 8OMQ 8R7C 8R7E 8R7V 8RZ7 8RZ8 8RZ9	3A1J 3G65 3GGR 6HM5 6J8Y 7Z6H 8GNN 8JZY 8WU8
GO Terms Enriched among Interactors		DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Radiation Response To Radiation Response To Ionizing Radiation Cellular Response To Stress Damaged DNA Binding Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle Checkpoint Clamp Complex Mismatch Repair DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition Nucleic Acid Metabolic Process Postreplication Repair DNA Recombination Negative Regulation Of Cell Cycle Process Nucleoplasm Response To Stress Signal Transduction In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes DNA Strand Resection Involved In Replication Fork Processing Somatic Diversification Of Immune Receptors Via Somatic Mutation Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Dinucleotide Insertion Or Deletion Binding Somatic Recombination Of Immunoglobulin Gene Segments BRCA1-B Complex Homologous Recombination Guanine/thymine Mispair Binding Apoptotic Signaling Pathway Somatic Diversification Of Immunoglobulins Chromosome Organization Response To UV Somatic Cell DNA Recombination Regulation Of Cell Cycle	DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling DNA Recombination Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Mismatch Repair Response To Stress Regulation Of Cell Cycle Process Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Macromolecule Metabolic Process Nucleoplasm Intracellular Signal Transduction Response To Ionizing Radiation Response To Radiation Damaged DNA Binding Nucleus Regulation Of DNA Metabolic Process Protein Localization To Site Of Double-strand Break Recombinational Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Base-excision Repair Enzyme Binding Regulation Of Mitotic Cell Cycle DNA Replication Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Chromosome, Telomeric Region Somatic Cell DNA Recombination Mitotic DNA Replication Checkpoint Signaling Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Recombination Mismatched DNA Binding Regulation Of DNA Recombination Guanine/thymine Mispair Binding Mitotic G2/M Transition Checkpoint