RPA4 and MUTYH

Number of citations: 0 (PubMedID 11092888)
Data Source: HPRD (in vitro, in vivo)

		RPA4	MUTYH
Name		replication protein A4	mutY DNA glycosylase
Structure		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding Telomeric DNA Binding	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA Binding Catalytic Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Replication Initiation DNA Repair Nucleotide-excision Repair DNA Recombination DNA Damage Response Nuclear DNA Replication	DNA Repair Base-excision Repair Mismatch Repair Response To Stress DNA Damage Response Depurination Negative Regulation Of Necroptotic Process
Pathways		Activation of the pre-replicative complex	None
Diseases		None	Familial adenomatous polyposis
GWAS		No GWAS studies recorded	Composite immunoglobulin trait (IgA/IgM) ( 28628107 ) Periventricular white matter hyperintensities ( 32517579 )
Novel Interactors		None recorded	1 novel interactors: TNFRSF9
Interacting Genes		6 interacting genes: APP MUTYH PTRHD1 RPA1 RPA3 XPA	19 interacting genes: AGTRAP APEX1 BAAT CYLC2 FANCC HRAS LMNA LRSAM1 MSANTD3 MSH6 PCNA RPA1 RPA4 SEC61B SIRT6 SMAD1 TDRD7 TSTD2 XPA
Entrez ID		29935	4595
HPRD ID		06591	05380
Ensembl ID		ENSG00000204086	ENSG00000132781
Uniprot IDs		Q13156	A0AAQ5BGW7 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 E9PP34 Q9UIF7
PDB IDs		Not available	1X51 3N5N 8FAY
GO Terms Enriched among Interactors		Base-excision Repair DNA Replication Factor A Complex Mismatch Repair Nucleotide-excision Repair Damaged DNA Binding DNA Repair DNA Metabolic Process DNA Damage Response DNA Binding Chromosome Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Adenine/guanine Mispair Binding Nucleotide-excision Repair, DNA Damage Recognition Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Stress Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Cellular Response To Stress Purine-specific Mismatch Base Pair DNA N-glycosylase Activity MutLbeta Complex Binding MutSbeta Complex Binding Recombinational Repair Telomere Maintenance Single-stranded DNA Binding Site Of Double-strand Break Double-strand Break Repair Via Homologous Recombination Telomere Organization Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Nucleotide-excision Repair Factor 1 Complex DNA Replication Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Depurination	Damaged DNA Binding Base-excision Repair DNA Repair Nucleotide-excision Repair DNA Replication Factor A Complex DNA Metabolic Process DNA Damage Response Chromosome, Telomeric Region Cellular Response To Stress Mismatch Repair Site Of Double-strand Break Response To Stress Response To UV MutLalpha Complex Binding Male Germ Cell Nucleus Chromosome Organization Nuclear Lamina Base-excision Repair, Gap-filling Response To Radiation DNA Recombination Telomere Maintenance Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Telomere Organization Protein Localization To Site Of Double-strand Break Response To Light Stimulus DNA Replication Protein Localization To Organelle Determination Of Adult Lifespan Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Telomere Maintenance Via Base-excision Repair Glycine N-choloyltransferase Activity Bile Acid Conjugation Meiotic Mismatch Repair Intrinsic Apoptotic Signaling Pathway Cellular Response To Radiation Protein Localization To Nucleus PCNA Complex Replisome Site Of DNA Damage Nucleotide-excision Repair, DNA Damage Recognition Endoplasmic Reticulum Sec Complex Histone H3K56 Deacetylase Activity, NAD-dependent Negative Regulation Of Cell Population Proliferation DNA-(abasic Site) Binding Nucleoplasm Double-stranded DNA Exodeoxyribonuclease Activity Deoxyribonuclease (pyrimidine Dimer) Activity