RPA4 and RPA3

Number of citations of the paper that reports this interaction (PMID 7760808)
14

Data Source:
HPRD (in vivo, in vitro)

		RPA4	RPA3
Gene Name		replication protein A4, 30kDa	replication protein A3, 14kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex	Nucleoplasm DNA Replication Factor A Complex
	Molecular Function	Single-stranded DNA Binding	Damaged DNA Binding Single-stranded DNA Binding Protein Binding
	Biological Process	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Initiation Nucleotide-excision Repair DNA Recombination Nuclear DNA Replication	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Regulation Of Cell Proliferation Regulation Of Cellular Response To Heat
Pathways		G1/S Transition Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Activation of the pre-replicative complex Mitotic G1-G1/S phases Cell Cycle, Mitotic	HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints
Drugs
Diseases
GWAS			Insulin-like growth factors ( 21216879)
Protein-Protein Interactions		7 interactors: APP MSH2 MSH3 MUTYH RPA1 RPA3 XPA	7 interactors: CDC5L MCM2 PRPF19 RAD51 RPA1 RPA2 RPA4
Entrez ID		29935	6119
HPRD ID		06591	01567
Ensembl ID		ENSG00000204086
Uniprot IDs		Q13156	A4D105 P35244
PDB IDs			1L1O 1QUQ 2PI2 2PQA 2Z6K 3KDF
Enriched GO Terms of Interacting Partners?		Mismatch Repair DNA Repair Nucleotide-excision Repair, DNA Damage Removal Cellular Response To DNA Damage Stimulus DNA Catabolic Process DNA Metabolic Process Meiotic Mismatch Repair DNA Recombination Maintenance Of DNA Repeat Elements Cellular Response To Stress Base-excision Repair DNA Recombinase Assembly Positive Regulation Of Helicase Activity Response To Stress Nucleotide-excision Repair Response To Abiotic Stimulus Aromatic Compound Catabolic Process Double-strand Break Repair Nucleotide-excision Repair, DNA Gap Filling Nucleobase-containing Compound Metabolic Process Meiotic Nuclear Division Telomere Maintenance Via Semi-conservative Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of DNA Recombination Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Nitrogen Compound Metabolic Process Meiotic Cell Cycle Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Nitrogen Compound Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cellular Macromolecule Catabolic Process Transcription-coupled Nucleotide-excision Repair Response To Light Stimulus Chromosome Organization Reproduction Cell Cycle Process Cellular Response To Stimulus Immunoglobulin Production Cellular Response To Heat Regulation Of DNA Recombination Regulation Of Mitotic Cell Cycle Telomere Maintenance Response To Radiation	DNA-dependent DNA Replication Cellular Response To DNA Damage Stimulus DNA Recombinase Assembly Cell Cycle Process DNA Metabolic Process DNA Repair Cell Cycle DNA Replication Cellular Response To Stress Double-strand Break Repair DNA Strand Elongation Involved In DNA Replication Mitotic Recombination DNA Damage Checkpoint DNA Strand Elongation G1/S Transition Of Mitotic Cell Cycle Protein-DNA Complex Assembly Cellular Macromolecular Complex Assembly Cell Cycle Checkpoint DNA Recombination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Stress Nucleotide-excision Repair DNA Unwinding Involved In DNA Replication Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleotide-excision Repair, DNA Gap Filling Nucleobase-containing Compound Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Regulation Of Double-strand Break Repair DNA Replication Initiation Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Response To Heat Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Nitrogen Compound Metabolic Process Transcription-coupled Nucleotide-excision Repair Cellular Component Assembly Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization
Tagcloud ?			analysing arabidopsis atrpa atrpa1a atrpa1b atrpa2a atrpa2b atrpa3a atrpa3b complexes differently electrophoretic heterologous heterotrimeric homologs idea interacts mobility preferentially purification rpa1 rpa2 shift similarity stranded subfunctionalization thaliana theory
Tagcloud (Difference) ?			analysing arabidopsis atrpa atrpa1a atrpa1b atrpa2a atrpa2b atrpa3a atrpa3b complexes differently electrophoretic heterologous heterotrimeric homologs idea interacts mobility preferentially purification rpa1 rpa2 shift similarity stranded subfunctionalization thaliana theory
Tagcloud (Intersection) ?