RPA4 and PTRHD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RPA4	PTRHD1
Description		replication protein A4	peptidyl-tRNA hydrolase domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break	Mitochondrion
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding Telomeric DNA Binding	Peptidyl-tRNA Hydrolase Activity Protein Binding Hydrolase Activity
	Biological Process	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Replication Initiation DNA Repair Nucleotide-excision Repair DNA Recombination DNA Damage Response Nuclear DNA Replication
Pathways		Activation of the pre-replicative complex
Drugs
Diseases
GWAS			Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: APP MUTYH PTRHD1 RPA1 RPA3 XPA	2 interacting genes: RPA4 TSR2
Entrez ID		29935	391356
HPRD ID		06591	18406
Ensembl ID		ENSG00000204086	ENSG00000184924
Uniprot IDs		Q13156	Q6GMV3
PDB IDs
Enriched GO Terms of Interacting Partners?		Base-excision Repair DNA Replication Factor A Complex Mismatch Repair Nucleotide-excision Repair Damaged DNA Binding DNA Repair DNA Metabolic Process DNA Damage Response DNA Binding Chromosome Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Adenine/guanine Mispair Binding Nucleotide-excision Repair, DNA Damage Recognition Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Stress Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Cellular Response To Stress Purine-specific Mismatch Base Pair DNA N-glycosylase Activity MutLbeta Complex Binding MutSbeta Complex Binding Recombinational Repair Telomere Maintenance Single-stranded DNA Binding Site Of Double-strand Break Double-strand Break Repair Via Homologous Recombination Telomere Organization Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Nucleotide-excision Repair Factor 1 Complex DNA Replication Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Depurination	Nuclear DNA Replication DNA Replication Factor A Complex DNA Replication Initiation Telomeric DNA Binding Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of SSU-rRNA Nucleotide-excision Repair DNA-templated DNA Replication
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