VWF and ZNF512B

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)

		VWF	ZNF512B
Gene Name		von Willebrand factor	zinc finger protein 512B
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Endoplasmic Reticulum External Side Of Plasma Membrane Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Glycoprotein Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein Homodimerization Activity Protein N-terminus Binding Chaperone Binding	DNA Binding Metal Ion Binding
	Biological Process	Liver Development Placenta Development Platelet Degranulation Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Response To Wounding Platelet Activation Extracellular Matrix Organization Cell-substrate Adhesion Protein Homooligomerization	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Platelet Adhesion to exposed collagen p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Intrinsic Pathway GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs		Antihemophilic Factor
Diseases
GWAS		Coagulation factor levels ( 23267103) Mean platelet volume ( 22139419) Platelet counts ( 22139419)	Prostate cancer ( 23535732)
Protein-Protein Interactions		16 interactors: ADAMTS13 ATXN7 CACNA1A CALR COL1A1 COL1A2 F8 FURIN GP1BA HSPA5 ITGA2B MAP3K3 RAC1 SOCS4 TNFRSF11B ZNF512B	60 interactors: ANKLE2 ANKRD28 AP1G1 APLP2 ATRX BRD1 BTBD2 CDC123 CREBZF CTBP2 DCTN1 DDX3X DROSHA DVL3 EHMT2 FAM129B FHL3 GLRX3 HEYL HTATSF1 IL36RN INVS KDM2A KDM3B KLF10 KMT2B L1TD1 LAMB2 LZTS2 MBD1 MYH10 OS9 PAPPA2 PBRM1 PDE4DIP PEG10 PIAS4 PLCG2 PPP1R15A PTPRF RPS27A SDF4 SIAH1 SMAD1 SPTBN1 SUPT5H TGM2 TNKS2 TOM1 TOX4 TRAF1 TRAF4 VHL VPS35 VPS41 VWF XPC XRCC6 YES1 ZMYM2
Entrez ID		7450	57473
HPRD ID		01906	13840
Ensembl ID		ENSG00000110799	ENSG00000196700
Uniprot IDs		P04275	Q96KM6
PDB IDs		1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4DMU	2GQJ
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Response To Stress Vesicle-mediated Transport Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Cell Communication Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Response To Organic Substance Signal Transduction Collagen Catabolic Process Cellular Response To Stimulus Platelet Degranulation Secretion By Cell Response To Stimulus Collagen Metabolic Process Signaling Multicellular Organismal Macromolecule Metabolic Process Protein Heterotrimerization Positive Regulation Of Leukocyte Migration Multicellular Organismal Metabolic Process Regulation Of Cell Migration Extracellular Matrix Disassembly Regulation Of Cell Motility Secretion Regulation Of Signaling Blood Coagulation, Intrinsic Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Leukocyte Migration Regulation Of Locomotion Exocytosis Cellular Localization Regulation Of Cellular Component Movement Anatomical Structure Arrangement Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction	Regulation Of Cellular Process Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organ Development System Development Transcription, DNA-templated Developmental Process Chromosome Organization Anatomical Structure Development Regulation Of Gene Expression RNA Biosynthetic Process Response To Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Biosynthetic Process Cell Cycle Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Cycle Process Multicellular Organismal Development Viral Genome Replication Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Wnt Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Organelle Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Chromatin Remodeling RNA Metabolic Process Primary MiRNA Processing Vesicle-mediated Transport Endosomal Transport Regulation Of Signal Transduction Cellular Response To Stress Mitotic Cell Cycle Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Gene Expression Response To Stress Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter
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Tagcloud (Difference) ?		afflicts atrophic blanching certified counseled dealing dexterity discriminant fingers fingertips hands incorporating lifelong manipulative multifrequency nonusers numbness outside physician priority sensorineural shipyard spasms tingling vibrating vibration vibratory worker worksite
Tagcloud (Intersection) ?